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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV.

Calcium-calmodulin-dependent protein kinase IV (CaMKIV) phosphorylates the major transcription factor cyclic AMP-response element binding protein (CREB), which plays a role in emotional behavior. Here, CaMKIV knockout mice (CaMKIV-/-) were tested in a battery of stress and anxiety-related behavioral tests, to determine if CaMKIV plays a role in emotional behavior. CaMKIV-/- exhibited a decrease in anxiety-like behavior in both the elevated plus maze and dark-light emergence tests when compared to wild-type mice. Both the acoustic startle response and prepulse inhibition of startle were decreased with the deletion of CaMKIV. In addition, CaMKIV-/- mice displayed a lack of stress-induced analgesia following restraint or cold swim stress. Our results demonstrate a key role for CaMKIV in anxiety and stress-related behavior.[1]


  1. Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV. Shum, F.W., Ko, S.W., Lee, Y.S., Kaang, B.K., Zhuo, M. Molecular pain [electronic resource] (2005) [Pubmed]
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