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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Synthesis and antiviral activity of novel chiral cyanoacrylate derivatives.

2-Cyanoacrylate is an important kind of herbicide targeted in photosystem II. Starting from cyano ethyl acetate, the chiral title compounds were synthesized under microwave irradiation, which has the advantages of shorter reaction time, higher yield, and simpler procedure. A half-leaf method was used to determine the inhibition and curative efficacies of the eight chiral products against tobacco mosaic virus in vivo. It was found that chiral compound IIc-R possesses moderate inhibition and curative effect in vivo with rates of 89.1 and 43.1%, respectively. In the MTT test, these new chiral compounds were found to possess weak antiproliferation activities to PC3 and A431 cells.[1]


  1. Synthesis and antiviral activity of novel chiral cyanoacrylate derivatives. Song, B., Zhang, H., Wang, H., Yang, S., Jin, L., Hu, D., Pang, L., Xue, W. J. Agric. Food Chem. (2005) [Pubmed]
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