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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Reaction Time

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Disease relevance of Reaction Time

  • Patients were assessed using a modified UCLA Parkinson Rating Scale of symptoms and signs, and neuropsychological testing including the Wechsler Adult Intelligence Scale-Revised, Wechsler Memory Scale, modified Thurstone Word Fluency Test, Wisconsin Card Sort, a test of visual vigilance, and a reaction time task [1].
  • Effect of the dopamine D2 receptor T allele on response latency after mild traumatic brain injury [2].
  • Under the conditions comprising 2.0 x 10(-3) M labeling reagent and 1.0 x 10(-5) M human lysozyme at pH 5.4, 37 degrees C, the reaction time required to reduce the lytic activity against Micrococcus luteus cells to 50% of its initial activity was lengthened by 3.7 times through the substitution of the nonreducing end sugar residue, GlcNAc to Gal [3].
  • CONCLUSIONS: Subtle changes in motor function, speed of movement, and reaction time are present in HD gene carriers who do not exhibit definite choreiform movements and who do not have sufficient signs to make a clinical diagnosis of HD [4].
  • Dopamine dependent reaction time deficits in patients with Parkinson's disease are task specific [5].

Psychiatry related information on Reaction Time


High impact information on Reaction Time

  • The many cellular effects of phorbol esters include the stimulation of glucose uptake, although the response of glucose uptake to phorbol esters appears to be complex, apparently varying in response time and requirement for protein synthesis [11].
  • Human simple reaction times and magnitude estimates of taste intensity increased as the duration of 500-millimolar sodium chloride or 2-millimolar saccharin sodium pulses lengthened from 100 to 1000 milliseconds [12].
  • A metric for thought: a comparison of P300 latency and reaction time [13].
  • In a discriminative reaction time test, caffeine treatment improved performance [14].
  • The influence of substance P on nociception depended on the individual mouse's sensitivity to pain (control response latency) [15].

Chemical compound and disease context of Reaction Time

  • Here, we measure the response time of the C2 domains of synaptotagmin to determine whether synaptotagmin is fast enough to function as a Ca2+ sensor for rapid exocytosis [16].
  • All patients showed clinical improvement as documented by decreased stool output and ability to be weaned off parenteral nutrition; response time ranged from 1 to 4 months after tacrolimus was begun [17].
  • Haloperidol (mean dose, 2.95 mg/day) caused significant decreases in Porteus Maze test quotient scores and a slowing of reaction time (RT) on a simple RT task [18].
  • Mean response time to the blocking vehicle was slowest after alcohol use (2.21 seconds) compared with fexofenadine use (1.95 seconds) [19].
  • A striking aspect of the reaction time course is that rapid O2-binding and trapping chemistry is followed by a progressive slowing down of succeeding steps in the process, which allows the various transient species to build up to concentrations sufficient for their detection by our time-resolved techniques [20].

Biological context of Reaction Time


Anatomical context of Reaction Time


Gene context of Reaction Time

  • Despite the same severity of symptoms on parent and teacher ratings for the ADHD subgroups, the average reaction times of the 7-present subgroup showed normal speed and variability of response whereas the average reaction times of the 7-absent subgroup showed the expected abnormalities (slow and variable responses) [31].
  • Surprisingly, on the hot plate (55 degrees C), the COX-1-deficient heterozygous groups showed less nociception, because mean reaction time was longer than that for controls [32].
  • Moreover, the time response of the stimulation of trans-acting factor binding by EGF suggests that the effect is directly due to growth factor and not mediated by changes in growth state [33].
  • HBP23 was constitutively expressed in KC and up-regulated on the protein and messenger RNA (mRNA) level by LPS with a time response distinct from that of TNFalpha, but in coordination with that of heme oxygenase-1 (HO-1), which is the inducible isoform of the rate-limiting enzyme of heme degradation [34].
  • Differential expression of hDIPP isoforms may provide flexibility in response times of the molecular switches [35].

Analytical, diagnostic and therapeutic context of Reaction Time

  • Following glutamine challenge there was a significant increase in blood ammonia from a mean fasting value ranging between 58 micromol/L to 120 micromol/L (P < .01), between significant prolongation of reaction times of 387 ms to 428 ms (P < .01), and an increase in mean EEG amplitude between 68.5 microV to 78.6 microV (P < .001) [36].
  • The results of the study support the view that bradykinetic-rigid syndromes involve some attentional deficits, but also have distinct reaction time and ERP characteristics, which may be helpful in differential diagnosis [37].
  • Formation mechanism of H2Ti3O7 nanotubes by single-step reaction of crystalline TiO2 and NaOH has been investigated via transmission electron microscopy examinations of series specimens with different reaction times and extensive ab initio calculations [38].
  • We compared osteoclast acid phosphatase (APase) activity in fresh frozen sections of neonatal rat calvaria using two different reaction methods; one is commonly employed for qualitative histochemistry and includes alpha naphthyl phosphate as substrate, simultaneous coupling to the chromagen Fast Garnet, and a 30-minute reaction time (method A) [39].
  • To assess the differential effect of these antihistamines on reaction times and subjective symptoms, we compared terfenadine, 60 mg twice daily, to hydroxyzine, 25 mg twice daily, in a double-blind, placebo-controlled, crossover study of 16 healthy, asymptomatic adults [40].


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  3. Origin of carbohydrate recognition specificity of human lysozyme revealed by affinity labeling. Muraki, M., Harata, K., Sugita, N., Sato, K. Biochemistry (1996) [Pubmed]
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  6. Induced hyperammonemia alters neuropsychology, brain MR spectroscopy and magnetization transfer in cirrhosis. Balata, S., Damink, S.W., Ferguson, K., Marshall, I., Hayes, P.C., Deutz, N.E., Williams, R., Wardlaw, J., Jalan, R. Hepatology (2003) [Pubmed]
  7. Effect of L-ornithine-L-aspartate on patients with and without TIPS undergoing glutamine challenge: a double blind, placebo controlled trial. Rees, C.J., Oppong, K., Al Mardini, H., Hudson, M., Record, C.O. Gut (2000) [Pubmed]
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  9. Hydergine effect on prolactin and reaction time in dementia. el Sobky, A., el Shazly, M., Darwish, A.K., Davies, T., Griffin, K., Keshavan, M.S. Biol. Psychiatry (1986) [Pubmed]
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  11. Phosphorylation of the glucose transporter in vitro and in vivo by protein kinase C. Witters, L.A., Vater, C.A., Lienhard, G.E. Nature (1985) [Pubmed]
  12. Taste flashes: reaction times, intensity, and quality. Kelling, S.T., Halpern, B.P. Science (1983) [Pubmed]
  13. A metric for thought: a comparison of P300 latency and reaction time. McCarthy, G., Donchin, E. Science (1981) [Pubmed]
  14. Anxiety and muscle tension as consequences of caffeine withdrawal. White, B.C., Lincoln, C.A., Pearce, N.W., Reeb, R., Vaida, C. Science (1980) [Pubmed]
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  16. Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes. Davis, A.F., Bai, J., Fasshauer, D., Wolowick, M.J., Lewis, J.L., Chapman, E.R. Neuron (1999) [Pubmed]
  17. Treatment of pediatric autoimmune enteropathy with tacrolimus (FK506). Bousvaros, A., Leichtner, A.M., Book, L., Shigeoka, A., Bilodeau, J., Semeao, E., Ruchelli, E., Mulberg, A.E. Gastroenterology (1996) [Pubmed]
  18. Cognitive effects of lithium carbonate and haloperidol in treatment-resistant aggressive children. Platt, J.E., Campbell, M., Green, W.H., Grega, D.M. Arch. Gen. Psychiatry (1984) [Pubmed]
  19. Effects of fexofenadine, diphenhydramine, and alcohol on driving performance. A randomized, placebo-controlled trial in the Iowa driving simulator. Weiler, J.M., Bloomfield, J.R., Woodworth, G.G., Grant, A.R., Layton, T.A., Brown, T.L., McKenzie, D.R., Baker, T.W., Watson, G.S. Ann. Intern. Med. (2000) [Pubmed]
  20. Resolution of the reaction sequence during the reduction of O2 by cytochrome oxidase. Varotsis, C., Zhang, Y., Appelman, E.H., Babcock, G.T. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  21. Saccade responses to dopamine in human MPTP-induced parkinsonism. Hotson, J.R., Langston, E.B., Langston, J.W. Ann. Neurol. (1986) [Pubmed]
  22. Combining low-intensity and maximal exercise test results improves prognostic prediction in chronic heart failure. Rickli, H., Kiowski, W., Brehm, M., Weilenmann, D., Schalcher, C., Bernheim, A., Oechslin, E., Brunner-La Rocca, H.P. J. Am. Coll. Cardiol. (2003) [Pubmed]
  23. DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients. Lencz, T., Robinson, D.G., Xu, K., Ekholm, J., Sevy, S., Gunduz-Bruce, H., Woerner, M.G., Kane, J.M., Goldman, D., Malhotra, A.K. The American journal of psychiatry. (2006) [Pubmed]
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  33. Regulation of transforming growth factor alpha expression in a growth factor-independent cell line. Howell, G.M., Humphrey, L.E., Ziober, B.L., Awwad, R., Periyasamy, B., Koterba, A., Li, W., Willson, J.K., Coleman, K., Carboni, J., Lynch, M., Brattain, M.G. Mol. Cell. Biol. (1998) [Pubmed]
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