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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Centaurin beta4 in cancer.

Centaurin beta4 proteins are products of the DDEF1 (development and differentiation-enhancing factor 1) locus on human chromosome 8q24.1-24. 2. Recent reports have indicated that this region and its products are amplified during development of several human cancers. Centaurins are GAPs (GTPase-activating proteins) that, together with GEFs (guanine nucleotide-exchange factors), regulate cyclic activation of Arfs (ADP-ribosylation factors), members of the Ras GTPase superfamily. Centaurin beta4 proteins associate with a variety of cellular signalling components implicated in control of growth, survival and movement and may act to direct assembly and/or disassembly of molecular complexes in concert with Arf, lipid and protein phosphorylation signalling pathways.[1]

References

  1. Centaurin beta4 in cancer. Martin, R.K., Jackson, T.R. Biochem. Soc. Trans. (2005) [Pubmed]
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