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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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ISL1 physically interacts with BETA2 to promote insulin gene transcriptional synergy in non-beta cells.

ISL1 is a LIM homeodomain protein that plays an important role in insulin gene transcriptional activation and islet cell formation. BETA2 is a transcription factor in the basic helix-loop-helix (bHLH) family, which activates expression of tissue-specific genes in several developmental systems. In this study, we investigated the functional and physical interactions of ISL1 and BETA2 in promoting insulin gene transcription in non-beta cells. Using the luciferase assay, we demonstrated that ISL1 and BETA2 could activate insulin gene transcription synergistically. Co-immunoprecipitation also supported that ISL1 and BETA2 appear in one complex and this physical interaction mediates the synergy between these two proteins.[1]

References

  1. ISL1 physically interacts with BETA2 to promote insulin gene transcriptional synergy in non-beta cells. Peng, S.Y., Wang, W.P., Meng, J., Li, T., Zhang, H., Li, Y.M., Chen, P., Ma, K.T., Zhou, C.Y. Biochim. Biophys. Acta (2005) [Pubmed]
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