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Stachel, D.K. et al.

Stachel, Leipold, Kuhlen, Gravou-Apostolatou, Hirv, Bader, Niemeyer, Beck, Holter,

Simultaneous control of third-degree graft-versus-host disease and prevention of recurrence of juvenile myelomonocytic leukemia (JMML) with 6-mercaptopurine following fulminant JMML relapse early after KIR-mismatched bone marrow transplantation.

The authors describe a young boy with juvenile myelomonocytic leukemia (JMML) who relapsed 45 days after HLA and killer immunoglobulin-like receptor ( KIR) mismatched unrelated donor bone marrow transplant (MMUD-BMT) and subsequently developed life-threatening graft-versus-host disease (GvHD). Treatment with 6-mercaptopurine (6-MP) appeared to control severe GvHD and possibly prevented recurrence of leukemic relapse.[1]

References

Simultaneous control of third-degree graft-versus-host disease and prevention of recurrence of juvenile myelomonocytic leukemia (JMML) with 6-mercaptopurine following fulminant JMML relapse early after KIR-mismatched bone marrow transplantation. Stachel, D.K., Leipold, A., Kuhlen, M., Gravou-Apostolatou, C., Hirv, K., Bader, P., Niemeyer, C.M., Beck, J.D., Holter, W. J. Pediatr. Hematol. Oncol. (2005) [Pubmed]

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