The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Leupurin     3,7-dihydropurine-6-thione

Synonyms: Purimethol, Purinethol, mercaptopurine, Puri-Nethol, Puri Nethol, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Leupurin


Psychiatry related information on Leupurin


High impact information on Leupurin


Chemical compound and disease context of Leupurin


Biological context of Leupurin


Anatomical context of Leupurin


Associations of Leupurin with other chemical compounds


Gene context of Leupurin


Analytical, diagnostic and therapeutic context of Leupurin


  1. Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study. Present, D.H., Korelitz, B.I., Wisch, N., Glass, J.L., Sachar, D.B., Pasternack, B.S. N. Engl. J. Med. (1980) [Pubmed]
  2. Systemic exposure to mercaptopurine as a prognostic factor in acute lymphocytic leukemia in children. Koren, G., Ferrazini, G., Sulh, H., Langevin, A.M., Kapelushnik, J., Klein, J., Giesbrecht, E., Soldin, S., Greenberg, M. N. Engl. J. Med. (1990) [Pubmed]
  3. Treatment of chronic disease with 6-mercaptopurine: what effects on fertility? Steckman, M.L. N. Engl. J. Med. (1980) [Pubmed]
  4. 6-Mercaptopurine treatment of pregnant mice: effects on second and third generations. Reimers, T.J., Sluss, P.M. Science (1978) [Pubmed]
  5. Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Weinshilboum, R.M., Otterness, D.M., Szumlanski, C.L. Annu. Rev. Pharmacol. Toxicol. (1999) [Pubmed]
  6. Human kidney thiopurine methyltransferase. Photoaffinity labeling with S-adenosyl-L-methionine. Van Loon, J.A., Szumlanski, C.L., Weinshilboum, R.M. Biochem. Pharmacol. (1992) [Pubmed]
  7. Current treatment for prevention of relapse and recurrence in Crohn's disease. Prantera, C., Scribano, M.L. Italian journal of gastroenterology and hepatology. (1999) [Pubmed]
  8. Complications of pregnancy and child development after cessation of treatment with 6-mercaptopurine for inflammatory bowel disease. Zlatanic, J., Korelitz, B.I., Rajapakse, R., Kim, P.S., Rubin, S.D., Baiocco, P.J., Panagopoulos, G. J. Clin. Gastroenterol. (2003) [Pubmed]
  9. HPLC analysis of 6-mercaptopurine and metabolites in extracellular body fluids. Rudy, J.L., Argyle, J.C., Winick, N., Van Dreal, P. Ann. Clin. Biochem. (1988) [Pubmed]
  10. Pharmacokinetics of mercaptopurine in children with acute lymphocytic leukemia. Adamson, P.C., Balis, F.M., Steinberg, S.M., Poplack, D.G., Holcenberg, J.S. N. Engl. J. Med. (1990) [Pubmed]
  11. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus. Relling, M.V., Hancock, M.L., Rivera, G.K., Sandlund, J.T., Ribeiro, R.C., Krynetski, E.Y., Pui, C.H., Evans, W.E. J. Natl. Cancer Inst. (1999) [Pubmed]
  12. Application of pharmacogenetics to optimization of mercaptopurine dosing. Balis, F.M., Adamson, P.C. J. Natl. Cancer Inst. (1999) [Pubmed]
  13. CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. Tiede, I., Fritz, G., Strand, S., Poppe, D., Dvorsky, R., Strand, D., Lehr, H.A., Wirtz, S., Becker, C., Atreya, R., Mudter, J., Hildner, K., Bartsch, B., Holtmann, M., Blumberg, R., Walczak, H., Iven, H., Galle, P.R., Ahmadian, M.R., Neurath, M.F. J. Clin. Invest. (2003) [Pubmed]
  14. 6-thioguanine can cause serious liver injury in inflammatory bowel disease patients. Dubinsky, M.C., Vasiliauskas, E.A., Singh, H., Abreu, M.T., Papadakis, K.A., Tran, T., Martin, P., Vierling, J.M., Geller, S.A., Targan, S.R., Poordad, F.F. Gastroenterology (2003) [Pubmed]
  15. A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease. Markowitz, J., Grancher, K., Kohn, N., Lesser, M., Daum, F. Gastroenterology (2000) [Pubmed]
  16. Postoperative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine, or placebo: a 2-year trial. Hanauer, S.B., Korelitz, B.I., Rutgeerts, P., Peppercorn, M.A., Thisted, R.A., Cohen, R.D., Present, D.H. Gastroenterology (2004) [Pubmed]
  17. Balsalazide and azathiprine or 6-mercaptopurine: evidence for a potentially serious drug interaction. Lowry, P.W., Szumlanski, C.L., Weinshilboum, R.M., Sandborn, W.J. Gastroenterology (1999) [Pubmed]
  18. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia. Lennard, L., Lilleyman, J.S., Van Loon, J., Weinshilboum, R.M. Lancet (1990) [Pubmed]
  19. Long-term follow-up of patients with Crohn's disease treated with azathioprine or 6-mercaptopurine. Bouhnik, Y., Lémann, M., Mary, J.Y., Scemama, G., Taï, R., Matuchansky, C., Modigliani, R., Rambaud, J.C. Lancet (1996) [Pubmed]
  20. Tissue-specific gene expression results from a purine- and pyrimidine-free diet and 6-mercaptopurine in the rat small intestine and colon. Leleiko, N.S., Martin, B.A., Walsh, M., Kazlow, P., Rabinowitz, S., Sterling, K. Gastroenterology (1987) [Pubmed]
  21. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Weinshilboum, R.M., Sladek, S.L. Am. J. Hum. Genet. (1980) [Pubmed]
  22. On the paradoxically concentration-dependent metabolism of 6-mercaptopurine in WEHI-3b murine leukemia cells. Liliemark, J., Pettersson, B., Engberg, B., Lafolie, P., Masquelier, M., Peterson, C. Cancer Res. (1990) [Pubmed]
  23. Quantitation of 6-thioguanine residues in peripheral blood leukocyte DNA obtained from patients receiving 6-mercaptopurine-based maintenance therapy. Warren, D.J., Andersen, A., Slørdal, L. Cancer Res. (1995) [Pubmed]
  24. Maintenance chemotherapy and cure of childhood acute lymphoblastic leukaemia. Gale, R.P., Butturini, A. Lancet (1991) [Pubmed]
  25. Relation of cellular drug resistance to long-term clinical outcome in childhood acute lymphoblastic leukaemia. Pieters, R., Huismans, D.R., Loonen, A.H., Hählen, K., van der Does-van den Berg, A., van Wering, E.R., Veerman, A.J. Lancet (1991) [Pubmed]
  26. Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. Kantarjian, H.M., O'Brien, S., Smith, T.L., Cortes, J., Giles, F.J., Beran, M., Pierce, S., Huh, Y., Andreeff, M., Koller, C., Ha, C.S., Keating, M.J., Murphy, S., Freireich, E.J. J. Clin. Oncol. (2000) [Pubmed]
  27. Treatment of CNS relapse in children with acute lymphoblastic leukemia: A Pediatric Oncology Group study. Winick, N.J., Smith, S.D., Shuster, J., Lauer, S., Wharam, M.D., Land, V., Buchanan, G., Rivera, G. J. Clin. Oncol. (1993) [Pubmed]
  28. Uptake, initial effects, and chemotherapeutic efficacy of harringtonine in murine leukemic cells sensitive and resistant to vincristine and other chemotherapeutic agents. Chou, T.C., Schmid, F.A., Feinberg, A., Philips, F.S., Han, J. Cancer Res. (1983) [Pubmed]
  29. Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance. Yates, C.R., Krynetski, E.Y., Loennechen, T., Fessing, M.Y., Tai, H.L., Pui, C.H., Relling, M.V., Evans, W.E. Ann. Intern. Med. (1997) [Pubmed]
  30. Reduced thiopurine methyltransferase activity and development of side effects of azathioprine treatment in patients with rheumatoid arthritis. Stolk, J.N., Boerbooms, A.M., de Abreu, R.A., de Koning, D.G., van Beusekom, H.J., Muller, W.H., van de Putte, L.B. Arthritis Rheum. (1998) [Pubmed]
  31. The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine. Wansa, K.D., Harris, J.M., Yan, G., Ordentlich, P., Muscat, G.E. J. Biol. Chem. (2003) [Pubmed]
  32. Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study. von Ahsen, N., Armstrong, V.W., Behrens, C., von Tirpitz, C., Stallmach, A., Herfarth, H., Stein, J., Bias, P., Adler, G., Shipkova, M., Oellerich, M., Kruis, W., Reinshagen, M. Clin. Chem. (2005) [Pubmed]
  33. Canine red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics. Salavaggione, O.E., Kidd, L., Prondzinski, J.L., Szumlanski, C.L., Pankratz, V.S., Wang, L., Trepanier, L., Weinshilboum, R.M. Pharmacogenetics (2002) [Pubmed]
  34. Variable bioavailability of oral mercaptopurine. Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered? Zimm, S., Collins, J.M., Riccardi, R., O'Neill, D., Narang, P.K., Chabner, B., Poplack, D.G. N. Engl. J. Med. (1983) [Pubmed]
  35. Additional discussion on the safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study. O'Connell, J.B. Gastroenterology (2004) [Pubmed]
  36. Long-term 6-mercaptopurine treatment in adolescents with Crohn's disease. Markowitz, J., Rosa, J., Grancher, K., Aiges, H., Daum, F. Gastroenterology (1990) [Pubmed]
  37. Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis. Pearson, D.C., May, G.R., Fick, G.H., Sutherland, L.R. Ann. Intern. Med. (1995) [Pubmed]
  38. Intensive therapy followed by bone marrow transplantation for patients with acute lymphocytic leukemia in second or subsequent remission: determination of prognostic factors (a report from the University of Minnesota Bone Marrow Transplantation Team). Woods, W.G., Nesbit, M.E., Ramsay, N.K., Krivit, W., Kim, T.H., Goldman, A., McGlave, P.B., Kersey, J.H. Blood (1983) [Pubmed]
WikiGenes - Universities