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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Bcr interferes with beta-catenin-Tcf1 interaction.

The beta-catenin/Tcf complex is a downstream effector of the Wnt signalling pathway. It is a transcription complex, which activates gene expression and contributes to proliferation and tumor progression. Tcf1 in complex with beta-catenin is able to activate beta-catenin-dependent gene expression. We demonstrate that expressed Bcr is able to bind the transcription factor Tcf1 to disrupt the Tcf1/beta-catenin complex. Phosphorylation of Bcr by the tyrosine kinase pp60(src) can lead to dissociation of the transcriptionally inactive Bcr/Tcf1 complex. Thus two independent mechanisms may regulate Tcf/beta-catenin-mediated transcription via Bcr: binding to beta-catenin as we have previously shown and to Tcf1 as shown here.[1]


  1. Bcr interferes with beta-catenin-Tcf1 interaction. Ress, A., Moelling, K. FEBS Lett. (2006) [Pubmed]
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