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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Sexual dimorphism of stress-induced changes in renal peripheral benzodiazepine receptors in rat.

Adult male and female rats were exposed to either inescapable shock or no treatment. In vitro [3H]Ro 5-4864 (4'-chlorodiazepam) binding (1 nM) to peripheral benzodiazepine receptors (PRB) in both CNS and peripheral tissues indicated no gender differences in olfactory bulb, heart, lung or adrenal gland but a significant effect was observed in renal tissue. Female rats showed an attenuated stress-induced reduction (23%) in PBR in comparison to males (55%). This difference was shown to be an alteration of Bmax and not kD by Scatchard analysis. These data are the first demonstration of a sexual dimorphism in environmentally-induced alterations in PBR.[1]

References

  1. Sexual dimorphism of stress-induced changes in renal peripheral benzodiazepine receptors in rat. Drugan, R.C., Holmes, P.V., Stringer, A.P. Neuropharmacology (1991) [Pubmed]
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