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Liao, J.M. et al.

Impaired micturition reflex caused by acute selective dorsal or ventral root(s) rhizotomy in anesthetized rats.

PURPOSE: To clarify the contributions of parasympathetic inputs and outputs to the micturition reflex. MATERIALS AND METHODS: Intra-vesical pressure (IVP), external urethral sphincter electromyogram (EMG), pelvic afferent nerve activities (PANA), and pelvic efferent nerve activities (PENA) as well as the time-derived IVP (dIVP, an index of bladder contractility) were evaluated in intact and acute dorsal or ventral root(s) rhizotomized ( DRX and VRX, respectively) rats. RESULTS: In DRX rats, when compared with that in intact stage, the voiding frequency was decreased (75 +/- 15% of intact, P < 0.05, n = 8), while the threshold pressure to trigger voiding contractions was significantly increased (187 +/- 75% of intact, P < 0.05, n = 8). In addition, several insufficient contractions (5.3 +/- 3.5 contractions/voiding, P < 0.05, n = 8) occurred in ahead of each voiding contraction. On the other hand, in VRX rats, the peak and rebound IVP were significantly decreased (90 +/- 3.5% and 75 +/- 11.3% of intact, P < 0.01, n = 8), while the threshold pressure was not affected (102 +/- 11% of intact, P = NS, n = 8). The time-derived parameters were significantly decreased in VRX (peak dIVP, 78 +/- 10.2%, rebound dIVP, 75 +/- 15.6%, minimal dIVP, 68 +/- 14% of intact, P < 0.01, n = 8) but only peak dIVP was decreased (85 +/- 11% of intact, P < 0.01, n = 8) in DRX rats. CONCLUSION: Acute selective DRX and VRX rat can be an animal model to investigate peripheral neural control in micturition functions. Neurourol. Urodynam. (c) 2006 Wiley-Liss, Inc.[1]

References

Impaired micturition reflex caused by acute selective dorsal or ventral root(s) rhizotomy in anesthetized rats. Liao, J.M., Cheng, C.L., Lee, S.D., Chen, G.D., Chen, K.J., Yang, C.H., Pan, S.F., Chen, M.J., Huang, P.C., Lin, T.B. Neurourology and urodynamics. (2006) [Pubmed]

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