The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Rhizotomy


High impact information on Rhizotomy

  • Flow was symmetrical within all brain regions in sham-operated animals and in the rhizotomy group, despite comparable increases in regional cerebral blood flow induced by angiotensin [6].
  • Furthermore, BDNF anterograde transport increased 3.5-fold within 24 hr after sciatic nerve injury or dorsal rhizotomy [7].
  • Cervical dorsal rhizotomy enhances serotonergic innervation of phrenic motoneurons and serotonin-dependent long-term facilitation of respiratory motor output in rats [8].
  • We tested the hypothesis that spinal plasticity elicited by chronic bilateral cervical dorsal rhizotomy (C3-C5; CDR) has functional implications for respiratory motor control [8].
  • When NGF had been infused into the central stump of the cut sciatic nerve, dorsal rhizotomy again increased CGRP levels in the DRG, despite prior section of the peripheral processes [9].

Chemical compound and disease context of Rhizotomy


Biological context of Rhizotomy


Anatomical context of Rhizotomy

  • For determination of anatomical loci of adenosine A1 receptors in the dorsal and ventral spinal cord, various lesions were employed, including kainic acid injections directly into the lumbar dorsal spinal cord, spinal cord hemitransections, dorsal rhizotomies, and neonatal capsaicin treatment [20].
  • (1) Dorsal rhizotomy depleted greater than one-third of the varicosities individually immunoreactive for SP, SOM, GAL, or DYN, confirming the association of these peptides with primary afferent neurons [21].
  • Unilateral upper two spinal dorsal rhizotomy prior to WGA-HRP application over the exposed basilar artery resulted in terminal labeling within the C2 dorsal horn, the cuneate nucleus, dmnX, and nTs contralateral to the rhizotomy, whereas the ipsilateral side was devoid of any labeling [22].
  • Regional distribution of calcitonin gene-related peptide-, substance P-, cholecystokinin-, Met5-enkephalin-, and dynorphin A (1-8)-like materials in the spinal cord and dorsal root ganglia of adult rats: effects of dorsal rhizotomy and neonatal capsaicin [23].
  • When spinal blood vessels were damaged during dorsal rhizotomy, the deficits in D-aspartate uptake and release were larger than those in the absence of vascular damage and were accompanied by deficits in GABA uptake and release [24].

Associations of Rhizotomy with chemical compounds

  • Intradermal capsaicin injection almost abolished exploratory activity in naïve animals or in rats after a DC lesion, but did not change it in rats after ipsilateral dorsal rhizotomy or a lesion of the lateral funiculus on the side opposite to the injection [25].
  • Bilateral dorsal rhizotomy (spinal segments C5-T1) and partial cordotomy (segment C5, right side) were used to interrupt primary sensory and descending tracts, respectively [26].
  • Blocking afferent inputs by application of bupivacaine mimicked the results of dorsal rhizotomy, in a reversible manner [27].
  • Three days following rhizotomy the number of GAD67 mRNA-expressing neurons was decreased in the superficial layers of the deafferented horn, while GABA immunostaining of axonal fibres located in this region was highly increased [28].
  • The sustained bladder response to subcutaneous bethanechol required greater sacral innervation than the detrusor reflex inasmuch as the S2 segment could subserve this response in only half the cases, and unilateral rhizotomy L7-S3 eliminated the response in half the cases [29].

Gene context of Rhizotomy


Analytical, diagnostic and therapeutic context of Rhizotomy


  1. Human trigeminal root evoked potentials during differential retrogasserian thermal and chemical rhizotomy. Macon, J.B., Poletti, C.E. Pain (1987) [Pubmed]
  2. Animal models of chronic pain: their possible validation from human experience with posterior rhizotomy and congenital analgesia (Part I of the second John J. Bonica lecture). Sweet, W.H. Pain (1981) [Pubmed]
  3. The effect of site and type of nerve injury on the expression of brain-derived neurotrophic factor in the dorsal root ganglion and on neuropathic pain behavior. Obata, K., Yamanaka, H., Kobayashi, K., Dai, Y., Mizushima, T., Katsura, H., Fukuoka, T., Tokunaga, A., Noguchi, K. Neuroscience (2006) [Pubmed]
  4. Renal afferent denervation prevents the progression of renal disease in the renal ablation model of chronic renal failure in the rat. Campese, V.M., Kogosov, E., Koss, M. Am. J. Kidney Dis. (1995) [Pubmed]
  5. Pseudorabies virus tracing of neural pathways between the uterine cervix and CNS: effects of survival time, estrogen treatment, rhizotomy, and pelvic nerve transection. Lee, J.W., Erskine, M.S. J. Comp. Neurol. (2000) [Pubmed]
  6. Trigeminovascular fibers increase blood flow in cortical gray matter by axon reflex-like mechanisms during acute severe hypertension or seizures. Sakas, D.E., Moskowitz, M.A., Wei, E.P., Kontos, H.A., Kano, M., Ogilvy, C.S. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  7. Axotomy upregulates the anterograde transport and expression of brain-derived neurotrophic factor by sensory neurons. Tonra, J.R., Curtis, R., Wong, V., Cliffer, K.D., Park, J.S., Timmes, A., Nguyen, T., Lindsay, R.M., Acheson, A., DiStefano, P.S. J. Neurosci. (1998) [Pubmed]
  8. Cervical dorsal rhizotomy enhances serotonergic innervation of phrenic motoneurons and serotonin-dependent long-term facilitation of respiratory motor output in rats. Kinkead, R., Zhan, W.Z., Prakash, Y.S., Bach, K.B., Sieck, G.C., Mitchell, G.S. J. Neurosci. (1998) [Pubmed]
  9. Cooperative regulation of calcitonin gene-related peptide levels in rat sensory neurons via their central and peripheral processes. Inaishi, Y., Kashihara, Y., Sakaguchi, M., Nawa, H., Kuno, M. J. Neurosci. (1992) [Pubmed]
  10. Glycerol rhizotomy versus gamma knife radiosurgery for the treatment of trigeminal neuralgia: an analysis of patients treated at one institution. Henson, C.F., Goldman, H.W., Rosenwasser, R.H., Downes, M.B., Bednarz, G., Pequignot, E.C., Werner-Wasik, M., Curran, W.J., Andrews, D.W. Int. J. Radiat. Oncol. Biol. Phys. (2005) [Pubmed]
  11. Capsaicin inhibits whereas rhizotomy potentiates substance P-induced release of excitatory amino acids in the rat spinal cord in vivo. Skilling, S.R., Larson, A.A. Neurosci. Lett. (1993) [Pubmed]
  12. Reliability of intraoperative electrophysiological monitoring in selective posterior rhizotomy. Mittal, S., Farmer, J.P., Poulin, C., Silver, K. J. Neurosurg. (2001) [Pubmed]
  13. Intravesical oxybutynin in patients with posterior rhizotomies and sacral anterior root stimulators. Singh, G., Thomas, D.G. Neurourology and urodynamics. (1995) [Pubmed]
  14. CT-guided chemical rhizotomy of the C1 root for occipital neuralgia. Koch, D., Wakhloo, A.K. Neuroradiology. (1992) [Pubmed]
  15. The effect of unilateral dorsal root ganglionectomies or ventral rhizotomies on alpha 2-adrenoceptor binding to, and the substance P, enkephalin, and neurotensin content of, the cat lumbar spinal cord. Howe, J.R., Yaksh, T.L., Go, V.L. Neuroscience (1987) [Pubmed]
  16. Nicotine-induced reflex depression of alpha motoneuron activity in the absence of fusimotor-spindle feedback. Ginzel, K.H., Estavillo, J., Eldred, E. J. Neurosci. Res. (1975) [Pubmed]
  17. Phosphorylation of extracellular signal-regulated kinases 1/2 is predominantly enhanced in the microglia of the rat spinal cord following dorsal root transection. Cheng, X.P., Wang, B.R., Liu, H.L., You, S.W., Huang, W.J., Jiao, X.Y., Ju, G. Neuroscience (2003) [Pubmed]
  18. Postural syncope and trigeminal neuralgia relieved by percutaneous rhizotomy with glycerol. Arias, M.J. Neurosurgery (1985) [Pubmed]
  19. Skeletal muscle contraction modulates carbonic anhydrase phenotype in adult mouse dorsal root ganglion neurons. Mayeux, V., Valmier, J. Brain Res. (1995) [Pubmed]
  20. Characterization and localization of adenosine receptors in rat spinal cord. Geiger, J.D., LaBella, F.S., Nagy, J.I. J. Neurosci. (1984) [Pubmed]
  21. A quantitative study of the coexistence of peptides in varicosities within the superficial laminae of the dorsal horn of the rat spinal cord. Tuchscherer, M.M., Seybold, V.S. J. Neurosci. (1989) [Pubmed]
  22. Brain stem terminations of the trigeminal and upper spinal ganglia innervation of the cerebrovascular system: WGA-HRP transganglionic study. Arbab, M.A., Delgado, T., Wiklund, L., Svendgaard, N.A. J. Cereb. Blood Flow Metab. (1988) [Pubmed]
  23. Regional distribution of calcitonin gene-related peptide-, substance P-, cholecystokinin-, Met5-enkephalin-, and dynorphin A (1-8)-like materials in the spinal cord and dorsal root ganglia of adult rats: effects of dorsal rhizotomy and neonatal capsaicin. Pohl, M., Benoliel, J.J., Bourgoin, S., Lombard, M.C., Mauborgne, A., Taquet, H., Carayon, A., Besson, J.M., Cesselin, F., Hamon, M. J. Neurochem. (1990) [Pubmed]
  24. Decreased uptake and release of D-aspartate in the guinea pig spinal cord after dorsal root section. Potashner, S.J., Tran, P.L. J. Neurochem. (1984) [Pubmed]
  25. The roles of pathways in the spinal cord lateral and dorsal funiculi in signaling nociceptive somatic and visceral stimuli in rats. Palecek, J., Paleckova, V., Willis, W.D. Pain (2002) [Pubmed]
  26. Amino acid levels in the guinea pig spinal gray matter after axotomy of primary sensory and descending tracts. Potashner, S.J., Dymczyk, L. J. Neurochem. (1986) [Pubmed]
  27. Contributions of injured and intact afferents to neuropathic pain in an experimental rat model. Yoon, Y.W., Na, H.S., Chung, J.M. Pain (1996) [Pubmed]
  28. Biphasic response of spinal GABAergic neurons after a lumbar rhizotomy in the adult rat. Dumoulin, A., Alonso, G., Privat, A., Feldblum, S. Eur. J. Neurosci. (1996) [Pubmed]
  29. Effect of acute selective sacral rhizotomy in cats on bladder and urethral function and the response to bethanechol chloride. el-Salmy, S., Downie, J.W., Awad, S.A. J. Urol. (1985) [Pubmed]
  30. Vasoactive intestinal polypeptide (VIP) increases in the spinal cord after peripheral axotomy of the sciatic nerve originate from primary afferent neurons. Shehab, S.A., Atkinson, M.E. Brain Res. (1986) [Pubmed]
  31. Cervical dorsal rhizotomy increases brain-derived neurotrophic factor and neurotrophin-3 expression in the ventral spinal cord. Johnson, R.A., Okragly, A.J., Haak-Frendscho, M., Mitchell, G.S. J. Neurosci. (2000) [Pubmed]
  32. Increased calcitonin gene-related peptide- and cholecystokinin-like immunoreactivities in spinal motoneurones after dorsal rhizotomy. Taquet, H., Plachot, J.J., Pohl, M., Collin, E., Benoliel, J.J., Bourgoin, S., Mauborgne, A., Meunier, J.C., Cesselin, F., Hamon, M. J. Neural Transm. Gen. Sect. (1992) [Pubmed]
  33. Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species. Gibson, S.J., Polak, J.M., Bloom, S.R., Sabate, I.M., Mulderry, P.M., Ghatei, M.A., McGregor, G.P., Morrison, J.F., Kelly, J.S., Evans, R.M. J. Neurosci. (1984) [Pubmed]
  34. Regulation of neuropilin 1 by spinal cord injury in adult rats. Agudo, M., Robinson, M., Cafferty, W., Bradbury, E.J., Kilkenny, C., Hunt, S.P., McMahon, S.B. Mol. Cell. Neurosci. (2005) [Pubmed]
  35. Expression and regulation of catecholaminergic traits in primary sensory neurons: relationship to target innervation in vivo. Katz, D.M., Black, I.B. J. Neurosci. (1986) [Pubmed]
  36. Urethral function after chronic cauda equina lesions in cats. I. The contribution of mechanical factors and sympathetic innervation to proximal sphincter dysfunction. Flood, H.D., Downie, J.W., Awad, S.A. J. Urol. (1990) [Pubmed]
  37. A soluble Nogo receptor differentially affects plasticity of spinally projecting axons. MacDermid, V.E., McPhail, L.T., Tsang, B., Rosenthal, A., Davies, A., Ramer, M.S. Eur. J. Neurosci. (2004) [Pubmed]
  38. Refractory occipital neuralgia: preoperative assessment with CT-guided nerve block prior to dorsal cervical rhizotomy. Kapoor, V., Rothfus, W.E., Grahovac, S.Z., Amin Kassam, S.Z., Horowitz, M.B. AJNR. American journal of neuroradiology. (2003) [Pubmed]
WikiGenes - Universities