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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Hennequin, L.F. et al.

Hennequin, Ballard, Boyle, Delouvrié, Ellston, Halsall, Harris, Hudson, Kendrew, Pease, Ross, Smith, Vincent,

Novel 4-anilinoquinazolines with C-6 carbon-linked side chains: synthesis and structure-activity relationship of a series of potent, orally active, EGF receptor tyrosine kinase inhibitors.

The structure-activity relationship of a novel subseries of 4-anilinoquinazoline EGFR inhibitors substituted at the C-6 position with carbon-linked side chains has been investigated. This exploration has led to the discovery of novel aminomethyl carboxamides with good biological, pharmacokinetic and physical properties.[1]

References

Novel 4-anilinoquinazolines with C-6 carbon-linked side chains: synthesis and structure-activity relationship of a series of potent, orally active, EGF receptor tyrosine kinase inhibitors. Hennequin, L.F., Ballard, P., Boyle, F.T., Delouvrié, B., Ellston, R.P., Halsall, C.T., Harris, C.S., Hudson, K., Kendrew, J., Pease, J.E., Ross, H.S., Smith, P., Vincent, J.L. Bioorg. Med. Chem. Lett. (2006) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg