Gene Review:
EGFR - epidermal growth factor receptor
Homo sapiens
Synonyms:
ERBB, ERBB1, Epidermal growth factor receptor, HER1, NISBD2, ...
Liana Adam,
Meng Zhong,
George Calin,
Milena Nicoloso,
Wei Qi,
Menashe Bar-Eli,
Ameeta Arora,
David McConkey,
Arlene Siefker-Radtke,
Colin Dinney,
Woonyoung Choi,
Hua Wang,
Shahrokh F. Shariat,
Claus G. Roehrborn,
Andrea Gallina,
Yair Lotan,
Jose A. Karam,
Kevin M. Slawin,
Karim Bensalah,
Pierre I. Karakiewicz,
Katharina Schmid,
Natalie Oehl,
Martin Filipits,
Christine Pirker,
Fritz Wrba,
Robert Pirker,
Nagendra Prasad,
- Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Pai, R., Soreghan, B., Szabo, I.L., Pavelka, M., Baatar, D., Tarnawski, A.S. Nat. Med. (2002)
- Direct interaction of a ligand for the erbB2 oncogene product with the EGF receptor and p185erbB2. Lupu, R., Colomer, R., Zugmaier, G., Sarup, J., Shepard, M., Slamon, D., Lippman, M.E. Science (1990)
- Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene. Velu, T.J., Beguinot, L., Vass, W.C., Willingham, M.C., Merlino, G.T., Pastan, I., Lowy, D.R. Science (1987)
- PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme. Smith, J.S., Tachibana, I., Passe, S.M., Huntley, B.K., Borell, T.J., Iturria, N., O'Fallon, J.R., Schaefer, P.L., Scheithauer, B.W., James, C.D., Buckner, J.C., Jenkins, R.B. J. Natl. Cancer Inst. (2001)
- Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab. Lu, Y., Li, X., Liang, K., Luwor, R., Siddik, Z.H., Mills, G.B., Mendelsohn, J., Fan, Z. Cancer Res. (2007)
- miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy. Adam, L., Zhong, M., Choi, W., Qi, W., Nicoloso, M., Arora, A., Calin, G., Wang, H., Siefker-Radtke, A., McConkey, D., Bar-Eli, M., Dinney, C. Clin. Cancer Res. (2009)
- EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases. Schmid, K., Oehl, N., Wrba, F., Pirker, R., Pirker, C., Filipits, M. Clin. Cancer Res. (2009)
- New strategies in head and neck cancer: understanding resistance to epidermal growth factor receptor inhibitors. Chen, L.F., Cohen, E.E., Grandis, J.R. Clin. Cancer Res. (2010)
- New strategies in overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer. Oxnard, G.R., Arcila, M.E., Chmielecki, J., Ladanyi, M., Miller, V.A., Pao, W. Clin. Cancer Res. (2011)
- Glioblastoma Stem-like Cell Lines with Either Maintenance or Loss of High-Level EGFR Amplification, Generated via Modulation of Ligand Concentration. Schulte, A., Günther, H.S., Martens, T., Zapf, S., Riethdorf, S., Wülfing, C., Stoupiec, M., Westphal, M., Lamszus, K. Clin. Cancer Res. (2012)
- High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan. Huang, S.F., Liu, H.P., Li, L.H., Ku, Y.C., Fu, Y.N., Tsai, H.Y., Chen, Y.T., Lin, Y.F., Chang, W.C., Kuo, H.P., Wu, Y.C., Chen, Y.R., Tsai, S.F. Clin. Cancer Res. (2004)
- UVB-induced epidermal growth factor receptor phosphorylation is critical for downstream signaling and keratinocyte survival. Peus, D., Vasa, R.A., Meves, A., Beyerle, A., Pittelkow, M.R. Photochem. Photobiol. (2000)
- Epidermal growth factor receptor expression in skin does not predict dementia in the elderly. Styren, S.D., Styren, G.C., DeKosky, S.T. Dementia and geriatric cognitive disorders. (1998)
- Increased serum concentrations of growth factor receptors and Neu in workers previously exposed to asbestos. Lahat, N., Froom, P., Kristal-Boneh, E., Cohen, C., Lerman, Y., Ribak, J. Occupational and environmental medicine. (1999)
- Conditioned place preference and locomotor sensitization after repeated administration of cocaine or methamphetamine in rats treated with epidermal growth factor during the neonatal period. Mizuno, M., Malta, R.S., Nagano, T., Nawa, H. Ann. N. Y. Acad. Sci. (2004)
- EGF receptor activation: push comes to shove. Hubbard, S.R. Cell (2006)
- An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Zhang, X., Gureasko, J., Shen, K., Cole, P.A., Kuriyan, J. Cell (2006)
- Receptor overexpression or inhibition alters cell surface dynamics of EGF-EGFR interaction: new insights from real-time single molecule analysis. Yu, C., Hale, J., Ritchie, K., Prasad, N.K., Irudayaraj, J. Biochem. Biophys. Res. Commun. (2009)
- Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR. Bell, D.W., Gore, I., Okimoto, R.A., Godin-Heymann, N., Sordella, R., Mulloy, R., Sharma, S.V., Brannigan, B.W., Mohapatra, G., Settleman, J., Haber, D.A. Nat. Genet. (2005)
- Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals. Tyner, J.W., Kim, E.Y., Ide, K., Pelletier, M.R., Roswit, W.T., Morton, J.D., Battaile, J.T., Patel, A.C., Patterson, G.A., Castro, M., Spoor, M.S., You, Y., Brody, S.L., Holtzman, M.J. J. Clin. Invest. (2006)
- A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells. Bektas, M., Payne, S.G., Liu, H., Goparaju, S., Milstien, S., Spiegel, S. J. Cell Biol. (2005)
- ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Engelman, J.A., Jänne, P.A., Mermel, C., Pearlberg, J., Mukohara, T., Fleet, C., Cichowski, K., Johnson, B.E., Cantley, L.C. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Kwak, E.L., Sordella, R., Bell, D.W., Godin-Heymann, N., Okimoto, R.A., Brannigan, B.W., Harris, P.L., Driscoll, D.R., Fidias, P., Lynch, T.J., Rabindran, S.K., McGinnis, J.P., Wissner, A., Sharma, S.V., Isselbacher, K.J., Settleman, J., Haber, D.A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Intron 1 CA dinucleotide repeat polymorphism and mutations of epidermal growth factor receptor and gefitinib responsiveness in non-small-cell lung cancer. Han, S.W., Jeon, Y.K., Lee, K.H., Keam, B., Hwang, P.G., Oh, D.Y., Lee, S.H., Kim, D.W., Im, S.A., Chung, D.H., Heo, D.S., Bang, Y.J., Kim, T.Y. Pharmacogenet. Genomics (2007)
- Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Ogiso, H., Ishitani, R., Nureki, O., Fukai, S., Yamanaka, M., Kim, J.H., Saito, K., Sakamoto, A., Inoue, M., Shirouzu, M., Yokoyama, S. Cell (2002)
- Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells. Di Fiore, P.P., Pierce, J.H., Fleming, T.P., Hazan, R., Ullrich, A., King, C.R., Schlessinger, J., Aaronson, S.A. Cell (1987)
- EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Wilde, A., Beattie, E.C., Lem, L., Riethof, D.A., Liu, S.H., Mobley, W.C., Soriano, P., Brodsky, F.M. Cell (1999)
- Enhanced degradation of EGF receptors by a sorting nexin, SNX1. Kurten, R.C., Cadena, D.L., Gill, G.N. Science (1996)
- Chimeric NGF-EGF receptors define domains responsible for neuronal differentiation. Yan, H., Schlessinger, J., Chao, M.V. Science (1991)
- Reduced epidermal growth factor receptor expression in hypohidrotic ectodermal dysplasia and Tabby mice. Vargas, G.A., Fantino, E., George-Nascimento, C., Gargus, J.J., Haigler, H.T. J. Clin. Invest. (1996)
- Alterations of human placental epidermal growth factor receptor in intrauterine growth retardation. Fondacci, C., Alsat, E., Gabriel, R., Blot, P., Nessmann, C., Evain-Brion, D. J. Clin. Invest. (1994)
- Abrogation of cisplatin-induced programmed cell death in human breast cancer cells by epidermal growth factor antisense RNA. Dixit, M., Yang, J.L., Poirier, M.C., Price, J.O., Andrews, P.A., Arteaga, C.L. J. Natl. Cancer Inst. (1997)
- A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling. Fallon, L., Bélanger, C.M., Corera, A.T., Kontogiannea, M., Regan-Klapisz, E., Moreau, F., Voortman, J., Haber, M., Rouleau, G., Thorarinsdottir, T., Brice, A., van Bergen En Henegouwen, P.M., Fon, E.A. Nat. Cell Biol. (2006)
- Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor. Swindle, C.S., Tran, K.T., Johnson, T.D., Banerjee, P., Mayes, A.M., Griffith, L., Wells, A. J. Cell Biol. (2001)
- Signal characteristics of G protein-transactivated EGF receptor. Daub, H., Wallasch, C., Lankenau, A., Herrlich, A., Ullrich, A. EMBO J. (1997)
- Suppression of epidermal growth factor receptor signaling by protein kinase C-alpha activation requires CD82, caveolin-1, and ganglioside. Wang, X.Q., Yan, Q., Sun, P., Liu, J.W., Go, L., McDaniel, S.M., Paller, A.S. Cancer Res. (2007)
- Staphylococcus aureus protein A activates TACE through EGFR-dependent signaling. Gómez, M.I., Seaghdha, M.O., Prince, A.S. EMBO J. (2007)
- The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells. Adachi, S., Nagao, T., Ingolfsson, H.I., Maxfield, F.R., Andersen, O.S., Kopelovich, L., Weinstein, I.B. Cancer Res. (2007)
- The Phosphatase Inhibitor Menadione (Vitamin K3) Protects Cells from EGFR Inhibition by Erlotinib and Cetuximab. Perez-Soler, R., Zou, Y., Li, T., Ling, Y.H. Clin. Cancer Res. (2011)
- Dual Kinase Inhibition of EGFR and HER2 Overcomes Resistance to Cetuximab in a Novel In Vivo Model of Acquired Cetuximab Resistance. Quesnelle, K.M., Grandis, J.R. Clin. Cancer Res. (2011)
- EGFR protein expression in non-small cell lung cancer predicts response to an EGFR tyrosine kinase inhibitor--a novel antibody for immunohistochemistry or AQUA technology. Mascaux, C., Wynes, M.W., Kato, Y., Tran, C., Asuncion, B.R., Zhao, J.M., Gustavson, M., Ranger-Moore, J., Gaire, F., Matsubayashi, J., Nagao, T., Yoshida, K., Ohira, T., Ikeda, N., Hirsch, F.R. Clin. Cancer Res. (2011)
- Transactivation of the EGF receptor mediates IGF-1-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells. Roudabush, F.L., Pierce, K.L., Maudsley, S., Khan, K.D., Luttrell, L.M. J. Biol. Chem. (2000)
- Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signaling. Keilhack, H., Tenev, T., Nyakatura, E., Godovac-Zimmermann, J., Nielsen, L., Seedorf, K., Böhmer, F.D. J. Biol. Chem. (1998)
- Enterophilin-1, a new partner of sorting nexin 1, decreases cell surface epidermal growth factor receptor. Pons, V., Hullin-Matsuda, F., Nauze, M., Barbaras, R., Pérès, C., Collet, X., Perret, B., Chap, H., Gassama-Diagne, A. J. Biol. Chem. (2003)
- RGS16 function is regulated by epidermal growth factor receptor-mediated tyrosine phosphorylation. Derrien, A., Druey, K.M. J. Biol. Chem. (2001)
- The RIalpha subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-receptor. Tortora, G., Damiano, V., Bianco, C., Baldassarre, G., Bianco, A.R., Lanfrancone, L., Pelicci, P.G., Ciardiello, F. Oncogene (1997)
- Helicobacter pylori protein HP0175 transactivates epidermal growth factor receptor through TLR4 in gastric epithelial cells. Basu, S., Pathak, S.K., Chatterjee, G., Pathak, S., Basu, J., Kundu, M. J. Biol. Chem. (2008)
- A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling. Blagoev, B., Kratchmarova, I., Ong, S.E., Nielsen, M., Foster, L.J., Mann, M. Nat. Biotechnol. (2003)
- Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk. Van Slyke, P., Coll, M.L., Master, Z., Kim, H., Filmus, J., Dumont, D.J. Mol. Cell. Biol. (2005)
- Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. Haas-Kogan, D.A., Prados, M.D., Tihan, T., Eberhard, D.A., Jelluma, N., Arvold, N.D., Baumber, R., Lamborn, K.R., Kapadia, A., Malec, M., Berger, M.S., Stokoe, D. J. Natl. Cancer Inst. (2005)
- A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. Gullapalli, A., Garrett, T.A., Paing, M.M., Griffin, C.T., Yang, Y., Trejo, J. Mol. Biol. Cell (2004)
- Endocytosis of epidermal growth factor receptor regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre. Martinu, L., Santiago-Walker, A., Qi, H., Chou, M.M. J. Biol. Chem. (2002)
- Prostacyclin receptor up-regulates the expression of angiogenic genes in human endometrium via cross talk with epidermal growth factor Receptor and the extracellular signaling receptor kinase 1/2 pathway. Smith, O.P., Battersby, S., Sales, K.J., Critchley, H.O., Jabbour, H.N. Endocrinology (2006)
- Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Croxtall, J.D., Choudhury, Q., Flower, R.J. Br. J. Pharmacol. (2000)
- Attenuation of EGF signaling in senescent cells by caveolin. Park, W.Y., Cho, K.A., Park, J.S., Kim, D.I., Park, S.C. Ann. N. Y. Acad. Sci. (2001)
- Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. Biswas, D.K., Cruz, A.P., Gansberger, E., Pardee, A.B. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Steroid receptor regulation of epidermal growth factor signaling through Src in breast and prostate cancer cells: steroid antagonist action. Migliaccio, A., Di Domenico, M., Castoria, G., Nanayakkara, M., Lombardi, M., de Falco, A., Bilancio, A., Varricchio, L., Ciociola, A., Auricchio, F. Cancer Res. (2005)
- PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli. Abe, T., Terada, K., Wakimoto, H., Inoue, R., Tyminski, E., Bookstein, R., Basilion, J.P., Chiocca, E.A. Cancer Res. (2003)
- Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Song, L., Morris, M., Bagui, T., Lee, F.Y., Jove, R., Haura, E.B. Cancer Res. (2006)
- SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. Zhang, Q., Thomas, S.M., Xi, S., Smithgall, T.E., Siegfried, J.M., Kamens, J., Gooding, W.E., Grandis, J.R. Cancer Res. (2004)
- Transient suppression of ligand-mediated activation of epidermal growth factor receptor by tumor necrosis factor-alpha through the TAK1-p38 signaling pathway. Singhirunnusorn, P., Ueno, Y., Matsuo, M., Suzuki, S., Saiki, I., Sakurai, H. J. Biol. Chem. (2007)
- Clostridium difficile toxin B activates the EGF receptor and the ERK/MAP kinase pathway in human colonocytes. Na, X., Zhao, D., Koon, H.W., Kim, H., Husmark, J., Moyer, M.P., Pothoulakis, C., LaMont, J.T. Gastroenterology (2005)
- GPI-anchored diphtheria toxin receptor allows membrane translocation of the toxin without detectable ion channel activity. Lanzrein, M., Sand, O., Olsnes, S. EMBO J. (1996)
- The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. Skolnik, E.Y., Lee, C.H., Batzer, A., Vicentini, L.M., Zhou, M., Daly, R., Myers, M.J., Backer, J.M., Ullrich, A., White, M.F. EMBO J. (1993)
- The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus. Kim, J., Jahng, W.J., Di Vizio, D., Lee, J.S., Jhaveri, R., Rubin, M.A., Shisheva, A., Freeman, M.R. Cancer Res. (2007)
- GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor. Su, X., Kong, C., Stahl, P.D. J. Biol. Chem. (2007)
- Preoperative plasma HER2 and epidermal growth factor receptor for staging and prognostication in patients with clinically localized prostate cancer. Shariat, S.F., Bensalah, K., Karam, J.A., Roehrborn, C.G., Gallina, A., Lotan, Y., Slawin, K.M., Karakiewicz, P.I. Clin. Cancer Res. (2007)
- EGFR-dependent migration of glial cells is mediated by reorganisation of N-cadherin. Rappl, A., Piontek, G., Schlegel, J. J. Cell. Sci. (2008)
- TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. Merchant, N.B., Voskresensky, I., Rogers, C.M., Lafleur, B., Dempsey, P.J., Graves-Deal, R., Revetta, F., Foutch, A.C., Rothenberg, M.L., Washington, M.K., Coffey, R.J. Clin. Cancer Res. (2008)
- Dissecting the effect of targeting the epidermal growth factor receptor on TGF-β-induced-apoptosis in human hepatocellular carcinoma cells. Caja, L., Sancho, P., Bertran, E., Fabregat, I. J. Hepatol. (2011)
- Control of EGF receptor signaling by clathrin-mediated endocytosis. Vieira, A.V., Lamaze, C., Schmid, S.L. Science (1996)
- Nuclear localization of EGF receptor and its potential new role as a transcription factor. Lin, S.Y., Makino, K., Xia, W., Matin, A., Wen, Y., Kwong, K.Y., Bourguignon, L., Hung, M.C. Nat. Cell Biol. (2001)
- The mechanism of cleavage of EGFR ligands induced by inflammatory cytokines in gastric cancer cells. Tanida, S., Joh, T., Itoh, K., Kataoka, H., Sasaki, M., Ohara, H., Nakazawa, T., Nomura, T., Kinugasa, Y., Ohmoto, H., Ishiguro, H., Yoshino, K., Higashiyama, S., Itoh, M. Gastroenterology (2004)