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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Computerized cognitive testing battery identifies mild cognitive impairment and mild dementia even in the presence of depressive symptoms.

Cognitive and depressive symptoms co-occur, complicating detection of mild cognitive impairment (MCI) and early dementia. In this study, discriminant validity of a novel computerized cognitive battery for MCI detection was evaluated after covariation for depressive symptom severity. In addition to the computerized battery, participants at two sites received the 30-item self-administered Geriatric Depression Scale (GDS; n=72); those at two other centers received the observer-administered Cornell Scale for Depression in Dementia (CSDD; n=88). In both cohorts, a Global Cognitive Score and memory, executive function, visual spatial, and verbal index scores discriminated among cognitively healthy, MCI, and mild dementia groups after covariation for GDS or CSDD, respectively (p < 0.05). Thus, the computerized battery for detection of mild impairment is robust to comorbid depressive symptoms, supporting its clinical utility in identifying neurodegenerative disease even in elderly with depression.[1]

References

  1. Computerized cognitive testing battery identifies mild cognitive impairment and mild dementia even in the presence of depressive symptoms. Doniger, G.M., Dwolatzky, T., Zucker, D.M., Chertkow, H., Crystal, H., Schweiger, A., Simon, E.S. American journal of Alzheimer's disease and other dementias. (2006) [Pubmed]
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