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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Depression


Psychiatry related information on Depression


High impact information on Depression


Chemical compound and disease context of Depression


Biological context of Depression


Anatomical context of Depression


Gene context of Depression

  • Our findings suggest that BDNF may be a susceptibility gene for MDD and schizophrenia-in particular, in a subgroup of patients with schizophrenia with a lifetime history of depressive symptoms [30].
  • There is some evidence that treatment with interleukin-2 (IL-2) and interferon-alpha (IFNalpha) frequently induces depressive symptoms and activation of the inflammatory response system (IRS) [31].
  • In these patients, the intensity of depressive symptoms at endpoint was positively correlated with the increases measured in serum levels of IL-10 between baseline and endpoint [32].
  • METHODS: Depressive symptoms were recorded, clinician ratings of disease activity were made, and blood was drawn for RA patients and controls at baseline and during a designated stressful week [33].
  • Assuming such impaired receptor function, then central secretion of CRH would be enhanced in many brain areas, which would account for a variety of depressive symptoms [34].

Analytical, diagnostic and therapeutic context of Depression

  • Chronic depressive symptoms were also associated with significantly greater decline in CD4 cell counts after controlling for other variables in the model, especially among women with baseline CD4 cell counts of less than 500 x 10(6)/L and baseline viral load greater than 10 000 copies/microL [1].
  • Participants with more depressive symptoms had higher levels of IL-6 before and after vaccination than did those who reported fewer symptoms; moreover, individuals reporting more depressive symptoms also showed an increase in plasma IL-6 levels 2 weeks later, while there was little change in IL-6 levels among those reporting few or no symptoms [35].
  • Fatigue was measured with the Multidimensional Fatigue Inventory (MFI-20) and HRQOL with a validated Dutch version of the RAND 36-Item Health Survey. We evaluated the impact of fatigue on HRQOL by multiple linear regression analyses taking into account RA-related pain and depressive symptoms [36].
  • There were no differences in the severity of depressive symptoms between the isotretinoin and antibiotic treatment groups before or after treatment [37].
  • Future longitudinal studies are needed to determine whether elevations in norepinephrine contribute to adverse cardiac outcomes in patients with depressive symptoms [38].


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  2. Side effects of adjuvant endocrine treatment in premenopausal breast cancer patients: a prospective randomized study. Nystedt, M., Berglund, G., Bolund, C., Fornander, T., Rutqvist, L.E. J. Clin. Oncol. (2003) [Pubmed]
  3. Regional cerebral glucose metabolism in bulimia nervosa. Andreason, P.J., Altemus, M., Zametkin, A.J., King, A.C., Lucinio, J., Cohen, R.M. The American journal of psychiatry. (1992) [Pubmed]
  4. The effects of propranolol on cognitive function and quality of life: a randomized trial among patients with diastolic hypertension. Pérez-Stable, E.J., Halliday, R., Gardiner, P.S., Baron, R.B., Hauck, W.W., Acree, M., Coates, T.J. Am. J. Med. (2000) [Pubmed]
  5. Changes in weight during a 1-year trial of fluoxetine. Michelson, D., Amsterdam, J.D., Quitkin, F.M., Reimherr, F.W., Rosenbaum, J.F., Zajecka, J., Sundell, K.L., Kim, Y., Beasley, C.M. The American journal of psychiatry. (1999) [Pubmed]
  6. Treatment of dysthymia and minor depression in primary care: A randomized controlled trial in older adults. Williams, J.W., Barrett, J., Oxman, T., Frank, E., Katon, W., Sullivan, M., Cornell, J., Sengupta, A. JAMA (2000) [Pubmed]
  7. The temporal relationship between depressive symptoms and dementia: a community-based prospective study. Chen, P., Ganguli, M., Mulsant, B.H., DeKosky, S.T. Arch. Gen. Psychiatry (1999) [Pubmed]
  8. Growth hormone and prolactin response to apomorphine in schizophrenia and the major affective disorders. Relation to duration of illness and depressive symptoms. Meltzer, H.Y., Kolakowska, T., Fang, V.S., Fogg, L., Robertson, A., Lewine, R., Strahilevitz, M., Busch, D. Arch. Gen. Psychiatry (1984) [Pubmed]
  9. Fluoxetine in depressed alcoholics. A double-blind, placebo-controlled trial. Cornelius, J.R., Salloum, I.M., Ehler, J.G., Jarrett, P.J., Cornelius, M.D., Perel, J.M., Thase, M.E., Black, A. Arch. Gen. Psychiatry (1997) [Pubmed]
  10. Effects of tryptophan depletion vs catecholamine depletion in patients with seasonal affective disorder in remission with light therapy. Neumeister, A., Turner, E.H., Matthews, J.R., Postolache, T.T., Barnett, R.L., Rauh, M., Vetticad, R.G., Kasper, S., Rosenthal, N.E. Arch. Gen. Psychiatry (1998) [Pubmed]
  11. Quality-of-life and depressive symptoms in postmenopausal women after receiving hormone therapy: results from the Heart and Estrogen/Progestin Replacement Study (HERS) trial. Hlatky, M.A., Boothroyd, D., Vittinghoff, E., Sharp, P., Whooley, M.A. JAMA (2002) [Pubmed]
  12. Similar effectiveness of paroxetine, fluoxetine, and sertraline in primary care: a randomized trial. Kroenke, K., West, S.L., Swindle, R., Gilsenan, A., Eckert, G.J., Dolor, R., Stang, P., Zhou, X.H., Hays, R., Weinberger, M. JAMA (2001) [Pubmed]
  13. Relapse of depressive symptoms after discontinuing sertraline. Baldessarini, R.J., Viguera, A.C. JAMA (1999) [Pubmed]
  14. BRCA1 testing in families with hereditary breast-ovarian cancer. A prospective study of patient decision making and outcomes. Lerman, C., Narod, S., Schulman, K., Hughes, C., Gomez-Caminero, A., Bonney, G., Gold, K., Trock, B., Main, D., Lynch, J., Fulmore, C., Snyder, C., Lemon, S.J., Conway, T., Tonin, P., Lenoir, G., Lynch, H. JAMA (1996) [Pubmed]
  15. Relapse of depression after rapid depletion of tryptophan. Smith, K.A., Fairburn, C.G., Cowen, P.J. Lancet (1997) [Pubmed]
  16. Depressive symptoms and cholesterol-lowering drugs. Duits, N., Bos, F.M. Lancet (1993) [Pubmed]
  17. The Northwick Park "functional" psychosis study: diagnosis and treatment response. Johnstone, E.C., Crow, T.J., Frith, C.D., Owens, D.G. Lancet (1988) [Pubmed]
  18. Depressive symptoms in hypercholesterolaemic patients treated with pravastatin. Lechleitner, M., Hoppichler, F., Konwalinka, G., Patsch, J.R., Braunsteiner, H. Lancet (1992) [Pubmed]
  19. Effects of 1-desamo-8-D-arginine vasopressin on behaviour and cognition in primary affective disorder. Gold, P.W., Weingartner, H., Ballenger, J.C., Goodwin, F.K., Post, R.M. Lancet (1979) [Pubmed]
  20. Antenatal maternal anxiety is related to HPA-axis dysregulation and self-reported depressive symptoms in adolescence: a prospective study on the fetal origins of depressed mood. Van den Bergh, B.R., Van Calster, B., Smits, T., Van Huffel, S., Lagae, L. Neuropsychopharmacology (2008) [Pubmed]
  21. Desipramine-yohimbine combination treatment of refractory depression. Implications for the beta-adrenergic receptor hypothesis of antidepressant action. Charney, D.S., Price, L.H., Heninger, G.R. Arch. Gen. Psychiatry (1986) [Pubmed]
  22. Testosterone administration in women with anorexia nervosa. Miller, K.K., Grieco, K.A., Klibanski, A. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  23. DHEA-S levels and depressive symptoms in a cohort of African American and Caucasian women in the late reproductive years. Morrison, M.F., Ten Have, T., Freeman, E.W., Sammel, M.D., Grisso, J.A. Biol. Psychiatry (2001) [Pubmed]
  24. Brain 5-HT1A, 5-HT1D, and 5-HT2 receptors in suicide victims. Arranz, B., Eriksson, A., Mellerup, E., Plenge, P., Marcusson, J. Biol. Psychiatry (1994) [Pubmed]
  25. Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers. London, E.D., Simon, S.L., Berman, S.M., Mandelkern, M.A., Lichtman, A.M., Bramen, J., Shinn, A.K., Miotto, K., Learn, J., Dong, Y., Matochik, J.A., Kurian, V., Newton, T., Woods, R., Rawson, R., Ling, W. Arch. Gen. Psychiatry (2004) [Pubmed]
  26. Major depressive disorder, alcoholism, and reduced natural killer cell cytotoxicity. Role of severity of depressive symptoms and alcohol consumption. Irwin, M., Caldwell, C., Smith, T.L., Brown, S., Schuckit, M.A., Gillin, J.C. Arch. Gen. Psychiatry (1990) [Pubmed]
  27. Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression. Saxena, S., Brody, A.L., Ho, M.L., Zohrabi, N., Maidment, K.M., Baxter, L.R. The American journal of psychiatry. (2003) [Pubmed]
  28. Does a combination regimen of thyroxine (T4) and 3,5,3'-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a double-blind, randomized, controlled trial. Sawka, A.M., Gerstein, H.C., Marriott, M.J., MacQueen, G.M., Joffe, R.T. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  29. A double-blind, controlled comparison of the novel antipsychotic olanzapine versus haloperidol or placebo on anxious and depressive symptoms accompanying schizophrenia. Tollefson, G.D., Sanger, T.M., Beasley, C.M., Tran, P.V. Biol. Psychiatry (1998) [Pubmed]
  30. Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Schumacher, J., Jamra, R.A., Becker, T., Ohlraun, S., Klopp, N., Binder, E.B., Schulze, T.G., Deschner, M., Schmäl, C., Höfels, S., Zobel, A., Illig, T., Propping, P., Holsboer, F., Rietschel, M., Nöthen, M.M., Cichon, S. Biol. Psychiatry (2005) [Pubmed]
  31. Lowered serum dipeptidyl peptidase IV activity is associated with depressive symptoms and cytokine production in cancer patients receiving interleukin-2-based immunotherapy. Maes, M., Capuron, L., Ravaud, A., Gualde, N., Bosmans, E., Egyed, B., Dantzer, R., Neveu, P.J. Neuropsychopharmacology (2001) [Pubmed]
  32. Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy. Capuron, L., Ravaud, A., Gualde, N., Bosmans, E., Dantzer, R., Maes, M., Neveu, P.J. Psychoneuroendocrinology (2001) [Pubmed]
  33. Immune activation and depression in women with rheumatoid arthritis. Zautra, A.J., Yocum, D.C., Villanueva, I., Smith, B., Davis, M.C., Attrep, J., Irwin, M. J. Rheumatol. (2004) [Pubmed]
  34. The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety. Holsboer, F. Journal of psychiatric research. (1999) [Pubmed]
  35. Mild depressive symptoms are associated with amplified and prolonged inflammatory responses after influenza virus vaccination in older adults. Glaser, R., Robles, T.F., Sheridan, J., Malarkey, W.B., Kiecolt-Glaser, J.K. Arch. Gen. Psychiatry (2003) [Pubmed]
  36. Impact of fatigue on health-related quality of life in rheumatoid arthritis. Rupp, I., Boshuizen, H.C., Jacobi, C.E., Dinant, H.J., van den Bos, G.A. Arthritis Rheum. (2004) [Pubmed]
  37. Functional brain imaging alterations in acne patients treated with isotretinoin. Bremner, J.D., Fani, N., Ashraf, A., Votaw, J.R., Brummer, M.E., Cummins, T., Vaccarino, V., Goodman, M.M., Reed, L., Siddiq, S., Nemeroff, C.B. The American journal of psychiatry. (2005) [Pubmed]
  38. Depressive symptoms and 24-hour urinary norepinephrine excretion levels in patients with coronary disease: findings from the Heart and Soul Study. Otte, C., Neylan, T.C., Pipkin, S.S., Browner, W.S., Whooley, M.A. The American journal of psychiatry. (2005) [Pubmed]
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