The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Neurodegenerative Diseases

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Neurodegenerative Diseases

 

Psychiatry related information on Neurodegenerative Diseases

 

High impact information on Neurodegenerative Diseases

 

Chemical compound and disease context of Neurodegenerative Diseases

 

Biological context of Neurodegenerative Diseases

 

Anatomical context of Neurodegenerative Diseases

 

Gene context of Neurodegenerative Diseases

 

Analytical, diagnostic and therapeutic context of Neurodegenerative Diseases

References

  1. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Shimura, H., Hattori, N., Kubo, S., Mizuno, Y., Asakawa, S., Minoshima, S., Shimizu, N., Iwai, K., Chiba, T., Tanaka, K., Suzuki, T. Nat. Genet. (2000) [Pubmed]
  2. The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy. Bomont, P., Cavalier, L., Blondeau, F., Ben Hamida, C., Belal, S., Tazir, M., Demir, E., Topaloglu, H., Korinthenberg, R., Tüysüz, B., Landrieu, P., Hentati, F., Koenig, M. Nat. Genet. (2000) [Pubmed]
  3. Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats. Imbert, G., Saudou, F., Yvert, G., Devys, D., Trottier, Y., Garnier, J.M., Weber, C., Mandel, J.L., Cancel, G., Abbas, N., Dürr, A., Didierjean, O., Stevanin, G., Agid, Y., Brice, A. Nat. Genet. (1996) [Pubmed]
  4. A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy. Kashima, T., Manley, J.L. Nat. Genet. (2003) [Pubmed]
  5. The gene for autosomal dominant cerebellar ataxia with pigmentary macular dystrophy maps to chromosome 3p12-p21.1. Benomar, A., Krols, L., Stevanin, G., Cancel, G., LeGuern, E., David, G., Ouhabi, H., Martin, J.J., Dürr, A., Zaim, A. Nat. Genet. (1995) [Pubmed]
  6. Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere. Gilliam, T.C., Tanzi, R.E., Haines, J.L., Bonner, T.I., Faryniarz, A.G., Hobbs, W.J., MacDonald, M.E., Cheng, S.V., Folstein, S.E., Conneally, P.M. Cell (1987) [Pubmed]
  7. Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells. Cook, D.G., Forman, M.S., Sung, J.C., Leight, S., Kolson, D.L., Iwatsubo, T., Lee, V.M., Doms, R.W. Nat. Med. (1997) [Pubmed]
  8. NMR structure of the mouse prion protein domain PrP(121-321). Riek, R., Hornemann, S., Wider, G., Billeter, M., Glockshuber, R., Wüthrich, K. Nature (1996) [Pubmed]
  9. Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease. Turmaine, M., Raza, A., Mahal, A., Mangiarini, L., Bates, G.P., Davies, S.W. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  10. Untangling tau-related dementia. Heutink, P. Hum. Mol. Genet. (2000) [Pubmed]
  11. TRP channel proteins and signal transduction. Minke, B., Cook, B. Physiol. Rev. (2002) [Pubmed]
  12. Spectrin mutations cause spinocerebellar ataxia type 5. Ikeda, Y., Dick, K.A., Weatherspoon, M.R., Gincel, D., Armbrust, K.R., Dalton, J.C., Stevanin, G., Dürr, A., Zühlke, C., Bürk, K., Clark, H.B., Brice, A., Rothstein, J.D., Schut, L.J., Day, J.W., Ranum, L.P. Nat. Genet. (2006) [Pubmed]
  13. In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets. Zhai, W., Jeong, H., Cui, L., Krainc, D., Tjian, R. Cell (2005) [Pubmed]
  14. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Giorgini, F., Guidetti, P., Nguyen, Q., Bennett, S.C., Muchowski, P.J. Nat. Genet. (2005) [Pubmed]
  15. The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Tsuda, H., Jafar-Nejad, H., Patel, A.J., Sun, Y., Chen, H.K., Rose, M.F., Venken, K.J., Botas, J., Orr, H.T., Bellen, H.J., Zoghbi, H.Y. Cell (2005) [Pubmed]
  16. A critical role for amino-terminal glutamine/asparagine repeats in the formation and propagation of a yeast prion. DePace, A.H., Santoso, A., Hillner, P., Weissman, J.S. Cell (1998) [Pubmed]
  17. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. Rothstein, J.D., Martin, L.J., Kuncl, R.W. N. Engl. J. Med. (1992) [Pubmed]
  18. Nitric oxide: a neural messenger. Jaffrey, S.R., Snyder, S.H. Annu. Rev. Cell Dev. Biol. (1995) [Pubmed]
  19. NMDA-dependent superoxide production and neurotoxicity. Lafon-Cazal, M., Pietri, S., Culcasi, M., Bockaert, J. Nature (1993) [Pubmed]
  20. The mechanism of kainic acid neurotoxicity. Garthwaite, J., Garthwaite, G. Nature (1983) [Pubmed]
  21. Evidence for a mechanism predisposing to intergenerational CAG repeat instability in spinocerebellar ataxia type I. Chung, M.Y., Ranum, L.P., Duvick, L.A., Servadio, A., Zoghbi, H.Y., Orr, H.T. Nat. Genet. (1993) [Pubmed]
  22. SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome. Zhu, Z., Yao, J., Johns, T., Fu, K., De Bie, I., Macmillan, C., Cuthbert, A.P., Newbold, R.F., Wang, J., Chevrette, M., Brown, G.K., Brown, R.M., Shoubridge, E.A. Nat. Genet. (1998) [Pubmed]
  23. Oxidative stress, glutamate, and neurodegenerative disorders. Coyle, J.T., Puttfarcken, P. Science (1993) [Pubmed]
  24. Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases. Chuang, D.M., Hough, C., Senatorov, V.V. Annu. Rev. Pharmacol. Toxicol. (2005) [Pubmed]
  25. Proteases for cell suicide: functions and regulation of caspases. Chang, H.Y., Yang, X. Microbiol. Mol. Biol. Rev. (2000) [Pubmed]
  26. Brain repair by endogenous progenitors. Kruger, G.M., Morrison, S.J. Cell (2002) [Pubmed]
  27. A conserved sorting-associated protein is mutant in chorea-acanthocytosis. Rampoldi, L., Dobson-Stone, C., Rubio, J.P., Danek, A., Chalmers, R.M., Wood, N.W., Verellen, C., Ferrer, X., Malandrini, A., Fabrizi, G.M., Brown, R., Vance, J., Pericak-Vance, M., Rudolf, G., Carrè, S., Alonso, E., Manfredi, M., Németh, A.H., Monaco, A.P. Nat. Genet. (2001) [Pubmed]
  28. The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1. Matilla, A., Koshy, B.T., Cummings, C.J., Isobe, T., Orr, H.T., Zoghbi, H.Y. Nature (1997) [Pubmed]
  29. Alzheimer's disease: a re-examination of the amyloid hypothesis. Neve, R.L., Robakis, N.K. Trends Neurosci. (1998) [Pubmed]
  30. Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. LaVaute, T., Smith, S., Cooperman, S., Iwai, K., Land, W., Meyron-Holtz, E., Drake, S.K., Miller, G., Abu-Asab, M., Tsokos, M., Switzer, R., Grinberg, A., Love, P., Tresser, N., Rouault, T.A. Nat. Genet. (2001) [Pubmed]
  31. A huntingtin-associated protein enriched in brain with implications for pathology. Li, X.J., Li, S.H., Sharp, A.H., Nucifora, F.C., Schilling, G., Lanahan, A., Worley, P., Snyder, S.H., Ross, C.A. Nature (1995) [Pubmed]
  32. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Patrick, G.N., Zukerberg, L., Nikolic, M., de la Monte, S., Dikkes, P., Tsai, L.H. Nature (1999) [Pubmed]
  33. The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans. Chalfie, M., Wolinsky, E. Nature (1990) [Pubmed]
  34. Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women's health initiative. Wise, P.M., Dubal, D.B., Rau, S.W., Brown, C.M., Suzuki, S. Endocr. Rev. (2005) [Pubmed]
  35. Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Nicoletti, F., Bruno, V., Copani, A., Casabona, G., Knöpfel, T. Trends Neurosci. (1996) [Pubmed]
  36. All neuropathies great and small. Penny, E.B., McCabe, B.D. J. Clin. Invest. (2005) [Pubmed]
  37. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. Kruman, I.I., Culmsee, C., Chan, S.L., Kruman, Y., Guo, Z., Penix, L., Mattson, M.P. J. Neurosci. (2000) [Pubmed]
  38. Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders. Takeda, A., Mallory, M., Sundsmo, M., Honer, W., Hansen, L., Masliah, E. Am. J. Pathol. (1998) [Pubmed]
 
WikiGenes - Universities