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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Carboxamide-pyridine N-oxide heterosynthon for crystal engineering and pharmaceutical cocrystals.

The novel carboxamide-pyridine N-oxide synthon, sustained via N-H...O- hydrogen bonding and C-H...O interaction, is shown to assemble isonicotinamide N-oxide in a triple helix architecture and the same heterosynthon is exploited to synthesize cocrystals of barbiturate drugs with 4,4'-bipyridine N,N'-dioxide.[1]

References

  1. Carboxamide-pyridine N-oxide heterosynthon for crystal engineering and pharmaceutical cocrystals. Reddy, L.S., Babu, N.J., Nangia, A. Chem. Commun. (Camb.) (2006) [Pubmed]
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