Disease relevance of Dopamine Nmethyltransferase

• We have examined the effect of difluoromethylornithine on the ability of B16 melanoma cells to take up putrescine and the 4,4'-dipyridyl herbicide paraquat [1].
• Recent epidemiological studies have brought to light a possible link between premalignant or neoplastic skin lesions (Bowen disease, squamous carcinoma) and occupational exposure to 4,4'-bipyridyl (4,4'B), a precursor in the synthesis of paraquat herbicide [2].
• Symptoms of toxicity for 4,4'-dipyridyl included subdued behavior, red stains around mouth and eyes, lacrimation, swelling around the eyes, and occasional convulsions [3].
• The widely used herbicide paraquat (1,1-dimethyl-4,4'-dipyridinium diiodide) and its precursor 4,4'-dipyridyl gave weak and marginal mutagenic activity to Salmonella typhimurium TA1535 and TA1538 in the presence of S9-mix [4].

High impact information on Dopamine Nmethyltransferase

• In situ synchrotron X-ray powder diffraction patterns of porous coordination polymers [[Cu(2)(pzdc)(2)(bpy)].G] have been measured (pzdc = pyrazine-2,3-dicarboxylate, bpy = 4,4'-bipyridine) (where G = H(2)O for CPL-2 superset H(2)()O, G = benzene for CPL-2 superset benzene, and G = void for the apohost) [5].
• In situ FT-Raman scattering spectroscopy was used to monitor the sorption kinetics of 2,2'- and 4,4'-bipyridine in acidic ZSM-5 zeolites [6].
• A marked gradation in active-centre properties in the cysteine proteinases revealed by neutral and anionic reactivity probes. Reactivity characteristics of the thiol groups of actinidin, ficin, papain and papaya peptidase A towards 4,4'-dipyridyl disulphide and 5,5'-dithiobis-(2-nitrobenzoate) dianion [7].
• The self-assembly behavior of zinc-metalated compounds with 4,4'-bipyridine and diazabenzoperylene has been investigated by (1)H NMR spectroscopy in CDCl(3), showing that oligomeric zigzag assemblies are formed [8].
• A Novel compound (Hbpy)2[[(H2O)3Ni(bpy)0.5Ni(bpy)(H2O)4]2[Mo5P2O23] [Ni((bpy)0.5)2(H2O)2][Mo5P2O23]].8H2O 1 (bpy = 4,4'-bipyridine) with an interpenetrating 2D network structure was synthesized hydrothermally and characterized by elemental analyses, IR, X-ray single crystal structure analysis and temperature-dependent magnetic susceptibility [9].

Biological context of Dopamine Nmethyltransferase

• The biotransformation of 4-phenylpyridine and 4,4'-bipyridyl to N-methylated quaternary ammonium metabolites in guinea pig and rabbit has been examined [10].
• We computed the electron transport properties of 4,4'-bipyridine (BP), 4,4'-bipyridinium-1,1'-bis(carbodithioate) (BPBC), 4-(4'-pyridyl)-peridium-1-carbodithioate (BPC) molecule junctions based on the density functional theory and nonequilibrium Green's functions [11].
• Dimerization of monoporphyrinate lanthanide complexes [Yb(Por)(H(2)O)(3)]Cl, (Por = TTP(2-), TMPP(2-) and TPP(2-)) in the presence of sterically hindered tripodal ligand, zinc Schiff-base, dilute HCl, K(2)CO(3) solution, 4,4'-bipyridine (bipy), and basic 8-hydroxyquinaldine (HQ) solution was observed in CH(2)Cl(2) at room temperature [12].

Anatomical context of Dopamine Nmethyltransferase

• In vitro cytotoxic effects of 4,4'-bipyridyl on normal human keratinocytes [2].

Associations of Dopamine Nmethyltransferase with other chemical compounds

• Two new phenylmalonate-bridged copper(II) complexes with the formulas [Cu(4,4'-bpy)(Phmal)](n).2nH(2)O (1) and [Cu(2,4'-bpy)(Phmal)(H(2)O)](n)() (2) (Phmal = phenylmalonate dianion, 4,4'-bpy = 4,4'-bipyridine, 2,4'-bpy = 2,4'-bipyridine) have been synthesized and characterized by X-ray diffraction [13].
• Two novel compounds, [Co(4,4'-bipy)(H(2)O)(4)](4-abs)(2).H(2)O (1) and [Mn(4,4'-bipy)(H(2)O)(4)](4-abs)(2).2H(2)O (2) (4,4'-bipy = 4,4'-bipyridine; 4-abs = 4-aminobenzenesulfonate), have been synthesized in aqueous solution and characterized by single-crystal X-ray diffraction, elemental analyses, UV-vis and IR spectra, and TG analysis [14].
• Using an alkaline solution (pH = 11.5) of 4,4'-bpy in the presence of tert-butyl alcohol, we studied the N-hydro radical 4,4'-bpyH* from room temperature to 400 degrees C at 25 MPa [15].
• X-ray crystal structures are reported for the ligand-bridged dicluster compounds [[(eta5-Cp')3Mo3S4Ni]2(mu-C4H4S2)][pts]2 (C4H8S2 = 1,4-dithiane) and [[(eta5-Cp')3Mo3S4Ni]2(mu-bipy)][pts]2 (bipy = 4,4'-bipyridine) [16].
• This paper reports a new mathematical model for consecutive two-dimensional phase transitions that accounts for the chronoamperometric behavior observed in the formation of electrochemical phases by 4,4'-bipyridyl cation radical (BpyH(2)(*)(+)) on mercury in aqueous iodide solutions [17].

Gene context of Dopamine Nmethyltransferase

• 4,4'-Dipyridyl disulfide also inhibited midazolam 1'-hydroxylase activity of CYP3A4 [18].
• We discovered 4,4'-dipyridyl disulfide to be a potent and relatively selective inhibitor of CYP2A6 [18].
• Inhibition of recombinant mouse wild type AChE (EC 3.1.1.7) and BChE (EC 3.1.1.8), and AChE peripheral site-directed mutants and human serum BChE variants by 4,4'-bipyridine (4,4'-BP) and the coumarin derivative 3-chloro-7-hydroxy-4-methylcoumarin (CHMC) was studied [19].
• In the analogous adducts C(10)H(18)N(2).C(4)H(6)O(6) formed by 4,4'-bipyridyl with racemic tartaric acid [(III), triclinic P1;, Z' = 1] and the chiral acid [(IV), monoclinic P2(1), Z' = 1], the hard hydrogen bonds generate bilayers which are again linked by C-H.O hydrogen bonds [20].
• It is well known that 4,4'-bipyridine acts as a redox promoter in the case of cytochrome c, whereas no electrochemical or electroreflectance response was observed in the case of cytochrome c3 [21].

Analytical, diagnostic and therapeutic context of Dopamine Nmethyltransferase

• [reaction: see text] Titration of porphyrin-fullerene rotaxanes with DABCO or 4,4'-bipyridine led to photo- and redoxactive catenanic architectures, which upon photoexcitation undergo a sequence of short-range energy and electron transfer events to give a long-lived charge-separated radical-pair state [22].
• The electronic structures of these complexes and those of the 4,4'-bipyridine (bpy) dimer, (Pt(pip2NCN))2(mu-bpy)2+, also have been investigated by UV-visible absorption and emission spectroscopies, as well as cyclic voltammetry [23].
• (4) The quantitative nature of the reverse-phase HPLC system also makes it a powerful method for analyzing the specificity and extent of chemical modification of specific subunits as is shown by the difference in reactivity of subunit VIa toward N-iodoacetylamidoethyl-1-aminonaphthalene-5-sulfonate and 4,4'-dipyridyl disulfide [24].
• Pulse radiolysis of 4,4'-bipyridyl aqueous solutions at elevated temperatures: spectral changes and reaction kinetics up to 400 degrees C [15].
• A historical-prospective cohort study was conducted of 729 male employees of plants manufacturing 4,4'-bipyridyl [25].

References