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Chemical Compound Review

SureCN9728     4-pyridin-4-ylpyridine

Synonyms: AGN-PC-00CUT4, SureCN602252, CCRIS 2363, CHEMBL1374568, CBDivE_014486, ...
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Disease relevance of Dopamine Nmethyltransferase


High impact information on Dopamine Nmethyltransferase

  • In situ synchrotron X-ray powder diffraction patterns of porous coordination polymers [[Cu(2)(pzdc)(2)(bpy)].G] have been measured (pzdc = pyrazine-2,3-dicarboxylate, bpy = 4,4'-bipyridine) (where G = H(2)O for CPL-2 superset H(2)()O, G = benzene for CPL-2 superset benzene, and G = void for the apohost) [5].
  • In situ FT-Raman scattering spectroscopy was used to monitor the sorption kinetics of 2,2'- and 4,4'-bipyridine in acidic ZSM-5 zeolites [6].
  • A marked gradation in active-centre properties in the cysteine proteinases revealed by neutral and anionic reactivity probes. Reactivity characteristics of the thiol groups of actinidin, ficin, papain and papaya peptidase A towards 4,4'-dipyridyl disulphide and 5,5'-dithiobis-(2-nitrobenzoate) dianion [7].
  • The self-assembly behavior of zinc-metalated compounds with 4,4'-bipyridine and diazabenzoperylene has been investigated by (1)H NMR spectroscopy in CDCl(3), showing that oligomeric zigzag assemblies are formed [8].
  • A Novel compound (Hbpy)2[[(H2O)3Ni(bpy)0.5Ni(bpy)(H2O)4]2[Mo5P2O23] [Ni((bpy)0.5)2(H2O)2][Mo5P2O23]].8H2O 1 (bpy = 4,4'-bipyridine) with an interpenetrating 2D network structure was synthesized hydrothermally and characterized by elemental analyses, IR, X-ray single crystal structure analysis and temperature-dependent magnetic susceptibility [9].

Biological context of Dopamine Nmethyltransferase

  • The biotransformation of 4-phenylpyridine and 4,4'-bipyridyl to N-methylated quaternary ammonium metabolites in guinea pig and rabbit has been examined [10].
  • We computed the electron transport properties of 4,4'-bipyridine (BP), 4,4'-bipyridinium-1,1'-bis(carbodithioate) (BPBC), 4-(4'-pyridyl)-peridium-1-carbodithioate (BPC) molecule junctions based on the density functional theory and nonequilibrium Green's functions [11].
  • Dimerization of monoporphyrinate lanthanide complexes [Yb(Por)(H(2)O)(3)]Cl, (Por = TTP(2-), TMPP(2-) and TPP(2-)) in the presence of sterically hindered tripodal ligand, zinc Schiff-base, dilute HCl, K(2)CO(3) solution, 4,4'-bipyridine (bipy), and basic 8-hydroxyquinaldine (HQ) solution was observed in CH(2)Cl(2) at room temperature [12].

Anatomical context of Dopamine Nmethyltransferase


Associations of Dopamine Nmethyltransferase with other chemical compounds

  • Two new phenylmalonate-bridged copper(II) complexes with the formulas [Cu(4,4'-bpy)(Phmal)](n).2nH(2)O (1) and [Cu(2,4'-bpy)(Phmal)(H(2)O)](n)() (2) (Phmal = phenylmalonate dianion, 4,4'-bpy = 4,4'-bipyridine, 2,4'-bpy = 2,4'-bipyridine) have been synthesized and characterized by X-ray diffraction [13].
  • Two novel compounds, [Co(4,4'-bipy)(H(2)O)(4)](4-abs)(2).H(2)O (1) and [Mn(4,4'-bipy)(H(2)O)(4)](4-abs)(2).2H(2)O (2) (4,4'-bipy = 4,4'-bipyridine; 4-abs = 4-aminobenzenesulfonate), have been synthesized in aqueous solution and characterized by single-crystal X-ray diffraction, elemental analyses, UV-vis and IR spectra, and TG analysis [14].
  • Using an alkaline solution (pH = 11.5) of 4,4'-bpy in the presence of tert-butyl alcohol, we studied the N-hydro radical 4,4'-bpyH* from room temperature to 400 degrees C at 25 MPa [15].
  • X-ray crystal structures are reported for the ligand-bridged dicluster compounds [[(eta5-Cp')3Mo3S4Ni]2(mu-C4H4S2)][pts]2 (C4H8S2 = 1,4-dithiane) and [[(eta5-Cp')3Mo3S4Ni]2(mu-bipy)][pts]2 (bipy = 4,4'-bipyridine) [16].
  • This paper reports a new mathematical model for consecutive two-dimensional phase transitions that accounts for the chronoamperometric behavior observed in the formation of electrochemical phases by 4,4'-bipyridyl cation radical (BpyH(2)(*)(+)) on mercury in aqueous iodide solutions [17].

Gene context of Dopamine Nmethyltransferase

  • 4,4'-Dipyridyl disulfide also inhibited midazolam 1'-hydroxylase activity of CYP3A4 [18].
  • We discovered 4,4'-dipyridyl disulfide to be a potent and relatively selective inhibitor of CYP2A6 [18].
  • Inhibition of recombinant mouse wild type AChE (EC and BChE (EC, and AChE peripheral site-directed mutants and human serum BChE variants by 4,4'-bipyridine (4,4'-BP) and the coumarin derivative 3-chloro-7-hydroxy-4-methylcoumarin (CHMC) was studied [19].
  • In the analogous adducts C(10)H(18)N(2).C(4)H(6)O(6) formed by 4,4'-bipyridyl with racemic tartaric acid [(III), triclinic P1;, Z' = 1] and the chiral acid [(IV), monoclinic P2(1), Z' = 1], the hard hydrogen bonds generate bilayers which are again linked by C-H.O hydrogen bonds [20].
  • It is well known that 4,4'-bipyridine acts as a redox promoter in the case of cytochrome c, whereas no electrochemical or electroreflectance response was observed in the case of cytochrome c3 [21].

Analytical, diagnostic and therapeutic context of Dopamine Nmethyltransferase

  • [reaction: see text] Titration of porphyrin-fullerene rotaxanes with DABCO or 4,4'-bipyridine led to photo- and redoxactive catenanic architectures, which upon photoexcitation undergo a sequence of short-range energy and electron transfer events to give a long-lived charge-separated radical-pair state [22].
  • The electronic structures of these complexes and those of the 4,4'-bipyridine (bpy) dimer, (Pt(pip2NCN))2(mu-bpy)2+, also have been investigated by UV-visible absorption and emission spectroscopies, as well as cyclic voltammetry [23].
  • (4) The quantitative nature of the reverse-phase HPLC system also makes it a powerful method for analyzing the specificity and extent of chemical modification of specific subunits as is shown by the difference in reactivity of subunit VIa toward N-iodoacetylamidoethyl-1-aminonaphthalene-5-sulfonate and 4,4'-dipyridyl disulfide [24].
  • Pulse radiolysis of 4,4'-bipyridyl aqueous solutions at elevated temperatures: spectral changes and reaction kinetics up to 400 degrees C [15].
  • A historical-prospective cohort study was conducted of 729 male employees of plants manufacturing 4,4'-bipyridyl [25].


  1. Paraquat is not accumulated in B16 tumor cells by the polyamine transport system. Minchin, R.F., Martin, R.L., Ilett, K.F. Life Sci. (1989) [Pubmed]
  2. In vitro cytotoxic effects of 4,4'-bipyridyl on normal human keratinocytes. Michel-Buono, M., Buono, J.P., Serre, G., Dumont, D., Bernard, P. Cell Biol. Toxicol. (1997) [Pubmed]
  3. Acute and subacute toxicity in Sherman strain rats exposed to 4,4'- and 2,2'-dipyridyl. Groce, D.F., Kimbrough, R.D. Journal of toxicology and environmental health. (1982) [Pubmed]
  4. Mutagenicity of dipyridyls and their methylated derivatives in Salmonella typhimurium/rat liver microsome system. Lin, J.K., Huang, I.H., Lee, K.W., Lin-Shiau, S.Y. Proc. Natl. Sci. Counc. Repub. China B (1989) [Pubmed]
  5. Guest shape-responsive fitting of porous coordination polymer with shrinkable framework. Matsuda, R., Kitaura, R., Kitagawa, S., Kubota, Y., Kobayashi, T.C., Horike, S., Takata, M. J. Am. Chem. Soc. (2004) [Pubmed]
  6. Conformation and protonation of 2,2'-bipyridine and 4,4'-bipyridine in acidic aqueous media and acidic ZSM-5 zeolites: a Raman scattering study. Moissette, A., Batonneau, Y., Brémard, C. J. Am. Chem. Soc. (2001) [Pubmed]
  7. A marked gradation in active-centre properties in the cysteine proteinases revealed by neutral and anionic reactivity probes. Reactivity characteristics of the thiol groups of actinidin, ficin, papain and papaya peptidase A towards 4,4'-dipyridyl disulphide and 5,5'-dithiobis-(2-nitrobenzoate) dianion. Brocklehurst, K., Mushiri, S.M., Patel, G., Willenbrock, F. Biochem. J. (1983) [Pubmed]
  8. Porphyrin-perylene bisimide dyads and triads: synthesis and optical and coordination properties. You, C.C., Würthner, F. Org. Lett. (2004) [Pubmed]
  9. A novel compound with an interpenetrating 2D network structure constructed by [Mo5P2O23] and Ni-4,4'-bipyridine components: its synthesis, characterization and magnetic behaviour. Chen, J., Lu, S., Yu, R., Chen, Z., Huang, Z., Lu, C. Chem. Commun. (Camb.) (2002) [Pubmed]
  10. N-methylation as a toxication route for xenobiotics. II. In vivo formation of N,N'-dimethyl-4,4'-bipyridyl ion (paraquat) from 4,4'-bipyridyl in the guinea pig. Godin, C.S., Crooks, P.A. Drug Metab. Dispos. (1989) [Pubmed]
  11. Dithiocarbamate anchoring in molecular wire junctions: a first principles study. Li, Z., Kosov, D.S. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2006) [Pubmed]
  12. Reactivity of aqua coordinated monoporphyrinate lanthanide complexes: synthetic, structural and photoluminescent studies of lanthanide porphyrinate dimers. He, H., Zhu, X., Hou, A., Guo, J., Wong, W.K., Wong, W.Y., Li, K.F., Cheah, K.W. Dalton transactions (Cambridge, England : 2003) (2004) [Pubmed]
  13. Polymeric networks of copper(II) phenylmalonate with heteroaromatic n-donor ligands: synthesis, crystal structure, and magnetic properties. Pasán, J., Sanchiz, J., Ruiz-Pérez, C., Lloret, F., Julve, M. Inorganic chemistry. (2005) [Pubmed]
  14. Novel hydrogen-bonded three-dimensional networks encapsulating one-dimensional covalent chains: [M(4,4'-bipy)(H2O)(4)](4-abs)(2).nH2O (4,4'-bipy = 4,4'-bipyridine; 4-abs = 4-aminobenzenesulfonate) (M = Co, n = 1; M = Mn, n = 2). Wang, Y., Feng, L., Li, Y., Hu, C., Wang, E., Hu, N., Jia, H. Inorganic chemistry. (2002) [Pubmed]
  15. Pulse radiolysis of 4,4'-bipyridyl aqueous solutions at elevated temperatures: spectral changes and reaction kinetics up to 400 degrees C. Lin, M., Katsumura, Y., He, H., Muroya, Y., Han, Z., Miyazaki, T., Kudo, H. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2005) [Pubmed]
  16. Molecular metal sulfide cluster model for substrate binding to oil-refinery hydrodesulfurization catalysts. Herbst, K., Monari, M., Brorson, M. Inorganic chemistry. (2002) [Pubmed]
  17. Chronoamperometric study of the films formed by 4,4'-bipyridyl cation radical salts on mercury in the presence of iodide ions: consecutive two-dimensional phase transitions. Gómez, L., Ruiz, J.J., Camacho, L., Rodríguez-Amaro, R. Langmuir : the ACS journal of surfaces and colloids. (2005) [Pubmed]
  18. Screening of organosulfur compounds as inhibitors of human CYP2A6. Fujita , K., Kamataki, T. Drug Metab. Dispos. (2001) [Pubmed]
  19. Reversible inhibition of acetylcholinesterase and butyrylcholinesterase by 4,4'-bipyridine and by a coumarin derivative. Simeon-Rudolf, V., Kovarik, Z., Radić, Z., Reiner, E. Chem. Biol. Interact. (1999) [Pubmed]
  20. Chiral versus racemic building blocks in supramolecular chemistry: tartrate salts of organic diamines. Farrell, D.M., Ferguson, G., Lough, A.J., Glidewell, C. Acta Crystallogr., B (2002) [Pubmed]
  21. Effect of surface modifiers on the electrode reactions and conformation of cytochrome c3 adsorbed on a silver electrode. Hobara, D., Niki, K., Cotton, T.M. Biospectroscopy. (1998) [Pubmed]
  22. Novel porphyrin-fullerene assemblies: from rotaxanes to catenanes. Schuster, D.I., Li, K., Guldi, D.M., Ramey, J. Org. Lett. (2004) [Pubmed]
  23. Luminescent platinum(II) dimers with a cyclometallating aryldiamine ligand. Jude, H., Bauer, J.A., Connick, W.B. Inorganic chemistry. (2005) [Pubmed]
  24. Separation and quantitation of cytochrome c oxidase subunits by Mono-Q fast protein liquid chromatography and C18 reverse-phase high-performance liquid chromatography. Liu, Y.C., Sowdal, L.H., Robinson, N.C. Arch. Biochem. Biophys. (1995) [Pubmed]
  25. Mortality of employees in plants manufacturing 4,4'-bipyridyl. Paddle, G.M., Osborn, A.J., Parker, G.D. Scandinavian journal of work, environment & health. (1991) [Pubmed]
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