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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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An allele of gyrA prevents Salmonella enterica serovar Typhimurium from using succinate as a carbon source.

A mutant gyrA allele resulting in an A271E substitution in the DNA gyrase protein generated a strain unable to grow on the C(4)-dicarboxylates succinate, malate, and fumarate. Bacteria harboring gyrA751 displayed decreased negative supercoiling in cells. Expression of the dctA gene, which encodes the C(4)-dicarboxylate transporter, was reduced in a gyrA751 mutant, providing the first evidence that dctA expression is supercoiling sensitive and uncovering a simple metabolic screen for lesions in gyrase that reduce negative supercoiling.[1]

References

  1. An allele of gyrA prevents Salmonella enterica serovar Typhimurium from using succinate as a carbon source. Schmitz, G.E., Downs, D.M. J. Bacteriol. (2006) [Pubmed]
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