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Chemical Compound Review

succinate     butanedioic acid

Synonyms: Wormwood, Asuccin, Katasuccin, succinic acid, Ammonium succinate, ...
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Disease relevance of succinic acid


Psychiatry related information on succinic acid


High impact information on succinic acid


Chemical compound and disease context of succinic acid


Biological context of succinic acid


Anatomical context of succinic acid


Associations of succinic acid with other chemical compounds


Gene context of succinic acid


Analytical, diagnostic and therapeutic context of succinic acid


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  10. Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency. Bourgeron, T., Rustin, P., Chretien, D., Birch-Machin, M., Bourgeois, M., Viegas-Péquignot, E., Munnich, A., Rötig, A. Nat. Genet. (1995) [Pubmed]
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  14. Multicenter trial of d-alpha-tocopheryl polyethylene glycol 1000 succinate for treatment of vitamin E deficiency in children with chronic cholestasis. Sokol, R.J., Butler-Simon, N., Conner, C., Heubi, J.E., Sinatra, F.R., Suchy, F.J., Heyman, M.B., Perrault, J., Rothbaum, R.J., Levy, J. Gastroenterology (1993) [Pubmed]
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  31. Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. Astuti, D., Latif, F., Dallol, A., Dahia, P.L., Douglas, F., George, E., Sköldberg, F., Husebye, E.S., Eng, C., Maher, E.R. Am. J. Hum. Genet. (2001) [Pubmed]
  32. Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma. Vanharanta, S., Buchta, M., McWhinney, S.R., Virta, S.K., Peçzkowska, M., Morrison, C.D., Lehtonen, R., Januszewicz, A., Järvinen, H., Juhola, M., Mecklin, J.P., Pukkala, E., Herva, R., Kiuru, M., Nupponen, N.N., Aaltonen, L.A., Neumann, H.P., Eng, C. Am. J. Hum. Genet. (2004) [Pubmed]
  33. Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Pollard, P.J., Brière, J.J., Alam, N.A., Barwell, J., Barclay, E., Wortham, N.C., Hunt, T., Mitchell, M., Olpin, S., Moat, S.J., Hargreaves, I.P., Heales, S.J., Chung, Y.L., Griffiths, J.R., Dalgleish, A., McGrath, J.A., Gleeson, M.J., Hodgson, S.V., Poulsom, R., Rustin, P., Tomlinson, I.P. Hum. Mol. Genet. (2005) [Pubmed]
  34. Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas. Gimenez-Roqueplo, A.P., Favier, J., Rustin, P., Rieubland, C., Crespin, M., Nau, V., Khau Van Kien, P., Corvol, P., Plouin, P.F., Jeunemaitre, X. Cancer Res. (2003) [Pubmed]
  35. Vitamin E succinate inhibits proliferation of BT-20 human breast cancer cells: increased binding of cyclin A negatively regulates E2F transactivation activity. Turley, J.M., Ruscetti, F.W., Kim, S.J., Fu, T., Gou, F.V., Birchenall-Roberts, M.C. Cancer Res. (1997) [Pubmed]
  36. Postischemic administration of succinate reverses the impairment of oxidative phosphorylation after cardiac ischemia and reperfusion injury. Cairns, C.B., Ferroggiaro, A.A., Walther, J.M., Harken, A.H., Banerjee, A. Circulation (1997) [Pubmed]
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