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Kim, S.W. et al.

Kim, Grant, Yoon, Williams, Remmel,

Safety of high-dose naltrexone treatment: hepatic transaminase profiles among outpatients.

OBJECTIVES: This study was carried out to test the hypothesis that the hepatic safety profile of prolonged high-dose oral naltrexone (150 mg/d) is acceptable if over-the-counter analgesic use is restricted. METHODS: Data from 41 consecutive outpatients with impulse-control disorder receiving naltrexone therapy were analyzed. RESULTS: The mean treatment duration was 328 days and the mean naltrexone dose was 142 mg/d. Pretherapy/posttherapy mean aspartate transaminase and alanine transaminase levels in the naltrexone-alone group were 21.79/22.54 and 21.74/21.49 U, respectively (all within reference range). CONCLUSIONS: Although limited in scope, these findings support the hypothesis that long-term use of high-dose oral naltrexone is safe in otherwise healthy patients with impulse-control disorders who restrict their intake of acetaminophen, aspirin, or nonaspirin nonsteroidal anti-inflammatory drugs (NSAID). However, confirming studies are needed.[1]

References

Safety of high-dose naltrexone treatment: hepatic transaminase profiles among outpatients. Kim, S.W., Grant, J.E., Yoon, G., Williams, K.A., Remmel, R.P. Clinical neuropharmacology. (2006) [Pubmed]

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