The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Reference Values

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Reference Values


Psychiatry related information on Reference Values

  • In logistic regression analyses, participants with depressive symptoms were more likely than those without depressive symptoms to have norepinephrine excretion levels in the highest quartile and above the normal range [6].
  • CO2 reactivity was in the normal range (4.4 +/- 1.2%) in the waking state and was markedly increased during sleep stages 1 and 2 (p less than 0.005 compared with awake) [7].
  • Although baseline AM and PM salivary cortisol levels were within reference range and did not differ significantly across groups, depression + PTSD patients differed from the other 2 groups in having a flattened diurnal pattern [8].
  • With placebo, scores in all 8 domains remained below normal values after 12 weeks, while patients receiving long-acting risperidone showed improvement in HRQoL toward normal levels, with clinically meaningful improvements in all mental-health domains [9].
  • In control subjects and patients with bilirubin less than 5 mg%, T-1/2 excretion values at 30, 40, and 50 min were similar to those values calculated using the entire 60 min of data, suggesting that the hepatic phase study time could be reduced to 30-40 min and still use the normal reference values established for 60 min [10].

High impact information on Reference Values


Chemical compound and disease context of Reference Values


Biological context of Reference Values


Anatomical context of Reference Values


Associations of Reference Values with chemical compounds


Gene context of Reference Values

  • Interestingly, the British and Turkish patients had complex III deficiency, whereas in the Finnish patients with GRACILE syndrome complex III activity was within the normal range, implying that BCS1L has another cellular function that is uncharacterized but essential and is putatively involved in iron metabolism [35].
  • In addition, serum MGF levels in these patients were within the normal range and MGF could not be detected in cell-free culture supernatants [36].
  • During a 1 year follow-up, blood cell parameters of Fancg KO mice remained within normal values, revealing no signs of anemia [37].
  • BS pool size and fecal BS excretion remained within the normal range in mice with Cav-1 overexpression [38].
  • These data show that genetic variants at the POMC locus influence body fat distribution within the normal range, suggesting a novel role for POMC in metabolic regulation [39].

Analytical, diagnostic and therapeutic context of Reference Values


  1. Age-specific reference ranges for prostate-specific antigen in black men. Morgan, T.O., Jacobsen, S.J., McCarthy, W.F., Jacobson, D.J., McLeod, D.G., Moul, J.W. N. Engl. J. Med. (1996) [Pubmed]
  2. Prevalence and pathologic features of sickle cell nephropathy and response to inhibition of angiotensin-converting enzyme. Falk, R.J., Scheinman, J., Phillips, G., Orringer, E., Johnson, A., Jennette, J.C. N. Engl. J. Med. (1992) [Pubmed]
  3. A novel mutation in the cystic fibrosis gene in patients with pulmonary disease but normal sweat chloride concentrations. Highsmith, W.E., Burch, L.H., Zhou, Z., Olsen, J.C., Boat, T.E., Spock, A., Gorvoy, J.D., Quittel, L., Friedman, K.J., Silverman, L.M. N. Engl. J. Med. (1994) [Pubmed]
  4. Serum levels of sex hormones in vulvar lichen sclerosus, and the effect of topical testosterone. Friedrich, E.G., Kalra, P.S. N. Engl. J. Med. (1984) [Pubmed]
  5. Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complications. Luetscher, J.A., Kraemer, F.B., Wilson, D.M., Schwartz, H.C., Bryer-Ash, M. N. Engl. J. Med. (1985) [Pubmed]
  6. Depressive symptoms and 24-hour urinary norepinephrine excretion levels in patients with coronary disease: findings from the Heart and Soul Study. Otte, C., Neylan, T.C., Pipkin, S.S., Browner, W.S., Whooley, M.A. The American journal of psychiatry. (2005) [Pubmed]
  7. Assessment of intracranial hemodynamics in sleep apnea syndrome. Klingelhöfer, J., Hajak, G., Sander, D., Schulz-Varszegi, M., Rüther, E., Conrad, B. Stroke (1992) [Pubmed]
  8. Paroxetine treatment of depression with posttraumatic stress disorder: effects on autonomic reactivity and cortisol secretion. Tucker, P., Beebe, K.L., Burgin, C., Wyatt, D.B., Parker, D.E., Masters, B.K., Nawar, O. Journal of clinical psychopharmacology. (2004) [Pubmed]
  9. Health-related quality of life in patients with schizophrenia during treatment with long-acting, injectable risperidone. Nasrallah, H.A., Duchesne, I., Mehnert, A., Janagap, C., Eerdekens, M. The Journal of clinical psychiatry. (2004) [Pubmed]
  10. Quantification of hepatobiliary function as an integral part of imaging with technetium-99m-mebrofenin in health and disease. Doo, E., Krishnamurthy, G.T., Eklem, M.J., Gilbert, S., Brown, P.H. J. Nucl. Med. (1991) [Pubmed]
  11. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Lewis, P.M., Dunn, M.P., McMahon, J.A., Logan, M., Martin, J.F., St-Jacques, B., McMahon, A.P. Cell (2001) [Pubmed]
  12. Dehydroepiandrosterone replacement in women with adrenal insufficiency. Arlt, W., Callies, F., van Vlijmen, J.C., Koehler, I., Reincke, M., Bidlingmaier, M., Huebler, D., Oettel, M., Ernst, M., Schulte, H.M., Allolio, B. N. Engl. J. Med. (1999) [Pubmed]
  13. Short-term inhibition of parathyroid hormone secretion by a calcium-receptor agonist in patients with primary hyperparathyroidism. Silverberg, S.J., Bone, H.G., Marriott, T.B., Locker, F.G., Thys-Jacobs, S., Dziem, G., Kaatz, S., Sanguinetti, E.L., Bilezikian, J.P. N. Engl. J. Med. (1997) [Pubmed]
  14. Age-specific reference ranges for serum PSA. Oesterling, J.E. N. Engl. J. Med. (1996) [Pubmed]
  15. A comparison of three interferon alfa-2b regimens for the long-term treatment of chronic non-A, non-B hepatitis. Multicenter Study Group. Poynard, T., Bedossa, P., Chevallier, M., Mathurin, P., Lemonnier, C., Trepo, C., Couzigou, P., Payen, J.L., Sajus, M., Costa, J.M. N. Engl. J. Med. (1995) [Pubmed]
  16. Transiently reduced activity of carbamyl phosphate synthetase and ornithine transcarbamylase in liver of children with Reye's syndrome. Brown, T., Hug, G., Lansky, L., Bove, K., Scheve, A., Ryan, M., Brown, H., Schubert, W.K., Partin, J.C., Lloyd-Still, J. N. Engl. J. Med. (1976) [Pubmed]
  17. Alterations in cation homeostasis in cultured chick ventricular cells during and after recovery from adenosine triphosphate depletion. Ishida, H., Kohmoto, O., Bridge, J.H., Barry, W.H. J. Clin. Invest. (1988) [Pubmed]
  18. Serum protein-bound carbohydrates for following the course of disease in patients with metastatic breast carcinoma. Waalkes, T.P., Mrochek, J.E., Dinsmore, S.R., Tormey, D.C. J. Natl. Cancer Inst. (1978) [Pubmed]
  19. Correction of hypokalemia corrects the abnormalities in erythrocyte sodium transport in Bartter's syndrome. Korff, J.M., Siebens, A.W., Gill, J.R. J. Clin. Invest. (1984) [Pubmed]
  20. Antioxidants in adipose tissue and risk of myocardial infarction: the EURAMIC Study. Kardinaal, A.F., Kok, F.J., Ringstad, J., Gomez-Aracena, J., Mazaev, V.P., Kohlmeier, L., Martin, B.C., Aro, A., Kark, J.D., Delgado-Rodriguez, M. Lancet (1993) [Pubmed]
  21. Induction of ovulation and fertility in amenorrheic women by pulsatile low-dose gonadotropin-releasing hormone. Hurley, D.M., Brian, R., Outch, K., Stockdale, J., Fry, A., Hackman, C., Clarke, I., Burger, H.G. N. Engl. J. Med. (1984) [Pubmed]
  22. Adrenaline-forming enzyme in brainstem: elevation in genetic and experimental hypertension. Saavedra, J.M., Grobecker, H., Axelrod, J. Science (1976) [Pubmed]
  23. Differential effects of insulin-like growth factor I and growth hormone on developmental stages of rat growth plate chondrocytes in vivo. Hunziker, E.B., Wagner, J., Zapf, J. J. Clin. Invest. (1994) [Pubmed]
  24. Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension. Pepke-Zaba, J., Higenbottam, T.W., Dinh-Xuan, A.T., Stone, D., Wallwork, J. Lancet (1991) [Pubmed]
  25. Brain edema in rabbits with galactosamine-induced fulminant hepatitis. Regional differences and effects on intracranial pressure. Traber, P.G., Ganger, D.R., Blei, A.T. Gastroenterology (1986) [Pubmed]
  26. Suppression of thyrotropin in the low-thyroxine state of severe nonthyroidal illness. Wehmann, R.E., Gregerman, R.I., Burns, W.H., Saral, R., Santos, G.W. N. Engl. J. Med. (1985) [Pubmed]
  27. Apolipoprotein A-I gene polymorphism associated with premature coronary artery disease and familial hypoalphalipoproteinemia. Ordovas, J.M., Schaefer, E.J., Salem, D., Ward, R.H., Glueck, C.J., Vergani, C., Wilson, P.W., Karathanasis, S.K. N. Engl. J. Med. (1986) [Pubmed]
  28. Transplantation of cultured thymic fragments. II. Results in nude mice. Hong, R., Schulte-Wissermann, H., Jarrett-Toth, E., Horowitz, S.D., Manning, D.D. J. Exp. Med. (1979) [Pubmed]
  29. Z-nucleotide accumulation in erythrocytes from Lesch-Nyhan patients. Sidi, Y., Mitchell, B.S. J. Clin. Invest. (1985) [Pubmed]
  30. Circumvention of defective neutral amino acid transport in Hartnup disease using tryptophan ethyl ester. Jonas, A.J., Butler, I.J. J. Clin. Invest. (1989) [Pubmed]
  31. A controlled trial of plasmapheresis therapy in severe lupus nephritis. The Lupus Nephritis Collaborative Study Group. Lewis, E.J., Hunsicker, L.G., Lan, S.P., Rohde, R.D., Lachin, J.M. N. Engl. J. Med. (1992) [Pubmed]
  32. Transient hyperammonemia of the preterm infant. Ballard, R.A., Vinocur, B., Reynolds, J.W., Wennberg, R.P., Merritt, A., Sweetman, L., Nyhan, W.L. N. Engl. J. Med. (1978) [Pubmed]
  33. Measurement of norepinephrine and 3,4-dihydroxyphenylglycol in urine and plasma for the diagnosis of pheochromocytoma. Duncan, M.W., Compton, P., Lazarus, L., Smythe, G.A. N. Engl. J. Med. (1988) [Pubmed]
  34. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. Lindenbaum, J., Healton, E.B., Savage, D.G., Brust, J.C., Garrett, T.J., Podell, E.R., Marcell, P.D., Stabler, S.P., Allen, R.H. N. Engl. J. Med. (1988) [Pubmed]
  35. GRACILE syndrome, a lethal metabolic disorder with iron overload, is caused by a point mutation in BCS1L. Visapää, I., Fellman, V., Vesa, J., Dasvarma, A., Hutton, J.L., Kumar, V., Payne, G.S., Makarow, M., Van Coster, R., Taylor, R.W., Turnbull, D.M., Suomalainen, A., Peltonen, L. Am. J. Hum. Genet. (2002) [Pubmed]
  36. Kit ligand/mast cell growth factor-independent differentiation of mast cells in myelodysplasia and chronic myeloid leukemic blast crisis. Valent, P., Spanblöchl, E., Bankl, H.C., Sperr, W.R., Marosi, C., Pirc-Danoewinata, H., Virgolini, I., Eichler, H.G., Agis, H., Sillaber, C. Blood (1994) [Pubmed]
  37. Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice. Koomen, M., Cheng, N.C., van de Vrugt, H.J., Godthelp, B.C., van der Valk, M.A., Oostra, A.B., Zdzienicka, M.Z., Joenje, H., Arwert, F. Hum. Mol. Genet. (2002) [Pubmed]
  38. Hepatic overexpression of caveolins increases bile salt secretion in mice. Moreno, M., Molina, H., Amigo, L., Zanlungo, S., Arrese, M., Rigotti, A., Miquel, J.F. Hepatology (2003) [Pubmed]
  39. Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study. Baker, M., Gaukrodger, N., Mayosi, B.M., Imrie, H., Farrall, M., Watkins, H., Connell, J.M., Avery, P.J., Keavney, B. Diabetes (2005) [Pubmed]
  40. Renal disease in type I glycogen storage disease. Chen, Y.T., Coleman, R.A., Scheinman, J.I., Kolbeck, P.C., Sidbury, J.B. N. Engl. J. Med. (1988) [Pubmed]
  41. Elevated serum levels of pancreatic secretory proteins in cigarette smokers after secretin stimulation. Balldin, G., Borgström, A., Eddeland, A., Genell, S., Hagberg, L., Ohlsson, K. J. Clin. Invest. (1980) [Pubmed]
  42. Plasma cholesterol metabolism in end-stage renal disease. Difference between treatment by hemodialysis or peritoneal dialysis. Dieplinger, H., Schoenfeld, P.Y., Fielding, C.J. J. Clin. Invest. (1986) [Pubmed]
  43. Substitution of aluminium salts by magnesium salts in control of dialysis hyperphosphataemia. O'Donovan, R., Baldwin, D., Hammer, M., Moniz, C., Parsons, V. Lancet (1986) [Pubmed]
  44. Reproducibility of hemoglobin AIc and sensitivity to various degrees of glucose intolerance. Dunn, P.J., Cole, R.A., Soeldner, J.S., Gleason, R.E. Ann. Intern. Med. (1979) [Pubmed]
WikiGenes - Universities