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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Paraneoplastic Coma and Acquired Central Alveolar Hypoventilation As a Manifestation of Brainstem Encephalitis in a Patient With ANNA-1 Antibody and Small-Cell Lung Cancer.

Introduction: Paraneoplastic neurological disorders are a well recognized complication of malignancy. Methods: A case report to expand the currently described clinical manifestations of type 1 antineuronal antibody (ANNA-1)-associated paraneoplastic encephalomyelitis to include coma. Results: We present an unusual case of fluctuating coma and rapid fulminant progression to acute respiratory failure from central alveolar hypoventilation caused by ANNA-1 paraneoplastic encephalomyelitis associated with small-cell lung carcinoma. Paraneoplastic infiltration of the brainstem and cerebellum, including respiratory and arousal centers, was documented on autopsy. Conclusions: Paraneoplastic encephalomyelitis should be considered as a possible cause of coma and central alveolar hypoventilation.[1]

References

  1. Paraneoplastic Coma and Acquired Central Alveolar Hypoventilation As a Manifestation of Brainstem Encephalitis in a Patient With ANNA-1 Antibody and Small-Cell Lung Cancer. Lee, K.S., Higgins, M.J., Patel, B.M., Larson, J.S., Rady, M.Y. Neurocritical care. (2006) [Pubmed]
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