Serine/threonine phosphatases in the nervous system.
The cloning and sequence determination of cDNAs encoding different types of serine/threonine protein phosphatases has provided a molecular basis for the protein phosphatase classification proposed by Ingebritsen and Cohen. Each of the phosphatases, phosphatase-1, -2A, -2B and -2C, exists as multiple isozymes raising the possibility that isozymes selectively expressed in different tissues may perform specific functions. The recent discovery of potent toxin inhibitors specific for protein phosphatase-1 and -2A will undoubtedly play an important role in the elucidation of the role of these enzymes in neuronal function.[1]References
- Serine/threonine phosphatases in the nervous system. Stemmer, P., Klee, C.B. Curr. Opin. Neurobiol. (1991) [Pubmed]
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