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Atanackovic, D. et al.

Atanackovic, Schnee, Schuch, Faltz, Schulze, Weber, Schafhausen, Bartels, Bokemeyer, Brunner-Weinzierl, Deter,

Acute psychological stress alerts the adaptive immune response: stress-induced mobilization of effector T cells.

Influences of psychological stress on the acquired immune system have not consequently been investigated. We found acute psychological stress to cause an increase in CD56+ and CCR5+ effector T cells in the peripheral blood of healthy human subjects (N=22), while skin-homing CLA+ T cells decreased. At the same time, we observed a stress-induced decrease in CD45RA+/CCR7+ naive and CD45RA-/CCR7+ central memory T cells, while CD45RA-/CCR7- effector memory and CD45RA+/CCR7- terminally differentiated T cells increased. This T cell redistribution translated into an increase in T cells expressing perforin/granzyme B and in Epstein-Barr virus-specific, cytomegalovirus-specific and influenza virus-specific CD8+ T cells. Thus, acute stress seems to promote the retention of less mature T cells within lymphoid tissue or skin while effector-type T cells are mobilized into the blood in order to be able to rapidly migrate into peripheral tissues.[1]

References

Acute psychological stress alerts the adaptive immune response: stress-induced mobilization of effector T cells. Atanackovic, D., Schnee, B., Schuch, G., Faltz, C., Schulze, J., Weber, C.S., Schafhausen, P., Bartels, K., Bokemeyer, C., Brunner-Weinzierl, M.C., Deter, H.C. J. Neuroimmunol. (2006) [Pubmed]

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