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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Landiolol enhances effect of ischemic preconditioning in isolated rabbit hearts.

The effect of the ultra-short-acting beta blocker, landiolol, on ischemic preconditioning was examined in isolated rabbit hearts. Ischemic preconditioned hearts received 2 episodes of 5 min each of global ischemia and reperfusion. The left anterior descending coronary artery was occluded for 1 hour and reperfused for 1 hour. Left ventricular end-systolic and end-diastolic pressures and infarct size were measured. Seven control hearts had no drug infused. Four groups of 6 hearts each were pretreated with 1 or 3 muM of landiolol or a combination of 1 or 3 muM landiolol and ischemic preconditioning. A further group of 6 hearts had ischemic preconditioning without landiolol. Ischemic preconditioning significantly reduced left ventricular end-diastolic pressure and infarct size compared to the controls. Landiolol alone did not change left ventricular end-diastolic pressure or infarct size, but landiolol 3 muM and ischemic preconditioning decreased left ventricular end-diastolic pressure more than preconditioning alone. These data suggest that pre-ischemic landiolol infusion may enhance the cardioprotective effect of ischemic preconditioning.[1]


  1. Landiolol enhances effect of ischemic preconditioning in isolated rabbit hearts. Mieno, S., Horimoto, H., Kishida, K., Horimoto, S., Sasaki, S. Asian cardiovascular & thoracic annals. (2006) [Pubmed]
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