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MeSH Review

Ischemic Preconditioning

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Disease relevance of Ischemic Preconditioning


High impact information on Ischemic Preconditioning


Chemical compound and disease context of Ischemic Preconditioning


Biological context of Ischemic Preconditioning


Anatomical context of Ischemic Preconditioning


Associations of Ischemic Preconditioning with chemical compounds


Gene context of Ischemic Preconditioning


Analytical, diagnostic and therapeutic context of Ischemic Preconditioning


  1. Infarct size-limiting effect of ischemic preconditioning is blunted by inhibition of 5'-nucleotidase activity and attenuation of adenosine release. Kitakaze, M., Hori, M., Morioka, T., Minamino, T., Takashima, S., Sato, H., Shinozaki, Y., Chujo, M., Mori, H., Inoue, M. Circulation (1994) [Pubmed]
  2. Dipyridamole potentiates the myocardial infarct size-limiting effect of ischemic preconditioning. Miura, T., Ogawa, T., Iwamoto, T., Shimamoto, K., Iimura, O. Circulation (1992) [Pubmed]
  3. Effect of ischemic preconditioning on interstitial purine metabolite and lactate accumulation during myocardial ischemia. Van Wylen, D.G. Circulation (1994) [Pubmed]
  4. Mechanisms of ischemic preconditioning in rat hearts. Involvement of alpha 1B-adrenoceptors, pertussis toxin-sensitive G proteins, and protein kinase C. Hu, K., Nattel, S. Circulation (1995) [Pubmed]
  5. Ischemic preconditioning during coronary angioplasty is prevented by glibenclamide, a selective ATP-sensitive K+ channel blocker. Tomai, F., Crea, F., Gaspardone, A., Versaci, F., De Paulis, R., Penta de Peppo, A., Chiariello, L., Gioffrè, P.A. Circulation (1994) [Pubmed]
  6. Formation of protein kinase C(epsilon)-Lck signaling modules confers cardioprotection. Ping, P., Song, C., Zhang, J., Guo, Y., Cao, X., Li, R.C., Wu, W., Vondriska, T.M., Pass, J.M., Tang, X.L., Pierce, W.M., Bolli, R. J. Clin. Invest. (2002) [Pubmed]
  7. Alpha 1-adrenoceptor activation mediates the infarct size-limiting effect of ischemic preconditioning through augmentation of 5'-nucleotidase activity. Kitakaze, M., Hori, M., Morioka, T., Minamino, T., Takashima, S., Sato, H., Shinozaki, Y., Chujo, M., Mori, H., Inoue, M. J. Clin. Invest. (1994) [Pubmed]
  8. Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats. Tejima, K., Arai, M., Ikeda, H., Tomiya, T., Yanase, M., Inoue, Y., Nagashima, K., Nishikawa, T., Watanabe, N., Omata, M., Fujiwara, K. Gastroenterology (2004) [Pubmed]
  9. Ischemic preconditioning: from adenosine receptor to KATP channel. Cohen, M.V., Baines, C.P., Downey, J.M. Annu. Rev. Physiol. (2000) [Pubmed]
  10. Protection of cardiac mitochondria by diazoxide and protein kinase C: implications for ischemic preconditioning. Korge, P., Honda, H.M., Weiss, J.N. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  11. Effect of aspirin on late preconditioning against myocardial stunning in conscious rabbits. Shinmura, K., Kodani, E., Xuan, Y.T., Dawn, B., Tang, X.L., Bolli, R. J. Am. Coll. Cardiol. (2003) [Pubmed]
  12. Glucosylceramide synthase activity and ceramide levels are modulated during cerebral ischemia after ischemic preconditioning. Takahashi, K., Ginis, I., Nishioka, R., Klimanis, D., Barone, F.C., White, R.F., Chen, Y., Hallenbeck, J.M. J. Cereb. Blood Flow Metab. (2004) [Pubmed]
  13. Ischemic preconditioning and glucose metabolism during low-flow ischemia: role of the adenosine A1 receptor. de Jonge, R., de Jong, J.W. Cardiovasc. Res. (1999) [Pubmed]
  14. Acetylcholine leads to free radical production dependent on K(ATP) channels, G(i) proteins, phosphatidylinositol 3-kinase and tyrosine kinase. Oldenburg, O., Qin, Q., Sharma, A.R., Cohen, M.V., Downey, J.M., Benoit, J.N. Cardiovasc. Res. (2002) [Pubmed]
  15. Cardiac interstitial bradykinin release during ischemia is enhanced by ischemic preconditioning. Pan, H.L., Chen, S.R., Scicli, G.M., Carretero, O.A. Am. J. Physiol. Heart Circ. Physiol. (2000) [Pubmed]
  16. PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the threshold for ischemic preconditioning in dogs. Mizumura, T., Auchampach, J.A., Linden, J., Bruns, R.F., Gross, G.J. Circ. Res. (1996) [Pubmed]
  17. Ischemic preconditioning protects the mouse liver by inhibition of apoptosis through a caspase-dependent pathway. Yadav, S.S., Sindram, D., Perry, D.K., Clavien, P.A. Hepatology (1999) [Pubmed]
  18. Hepatic ischemic preconditioning in mice is associated with activation of NF-kappaB, p38 kinase, and cell cycle entry. Teoh, N., Dela Pena, A., Farrell, G. Hepatology (2002) [Pubmed]
  19. Regulation of glycolytic flux in ischemic preconditioning. A study employing metabolic control analysis. Vogt, A.M., Poolman, M., Ackermann, C., Yildiz, M., Schoels, W., Fell, D.A., Kubler, W. J. Biol. Chem. (2002) [Pubmed]
  20. Energy metabolism after ischemic preconditioning in streptozotocin-induced diabetic rat hearts. Tatsumi, T., Matoba, S., Kobara, M., Keira, N., Kawahara, A., Tsuruyama, K., Tanaka, T., Katamura, M., Nakagawa, C., Ohta, B., Yamahara, Y., Asayama, J., Nakagawa, M. J. Am. Coll. Cardiol. (1998) [Pubmed]
  21. Oral sulfonylurea hypoglycemic agents prevent ischemic preconditioning in human myocardium. Two paradoxes revisited. Cleveland, J.C., Meldrum, D.R., Cain, B.S., Banerjee, A., Harken, A.H. Circulation (1997) [Pubmed]
  22. Contribution of adenosine A(2) receptors and cyclic adenosine monophosphate to protective ischemic preconditioning of sinusoidal endothelial cells against Storage/Reperfusion injury in rat livers. Arai, M., Thurman, R.G., Lemasters, J.J. Hepatology (2000) [Pubmed]
  23. Pharmacologic preconditioning of estrogen by activation of the myocardial adenosine triphosphate-sensitive potassium channel in patients undergoing coronary angioplasty. Lee, T.M., Su, S.F., Chou, T.F., Tsai, C.H. J. Am. Coll. Cardiol. (2002) [Pubmed]
  24. The sulfonylurea controversy: more questions from the heart. Brady, P.A., Terzic, A. J. Am. Coll. Cardiol. (1998) [Pubmed]
  25. Ischemic preconditioning suppresses the noradrenaline turnover in the rat heart. Takasaki, Y., Adachi, N., Dote, K., Tsubota, S., Yorozuya, T., Arai, T. Cardiovasc. Res. (1998) [Pubmed]
  26. Ischemic preconditioning in pigs: a graded phenomenon: its relation to adenosine and bradykinin. Schulz, R., Post, H., Vahlhaus, C., Heusch, G. Circulation (1998) [Pubmed]
  27. An essential role of the JAK-STAT pathway in ischemic preconditioning. Xuan, Y.T., Guo, Y., Han, H., Zhu, Y., Bolli, R. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  28. Alpha-adrenoceptor stimulation with exogenous norepinephrine or release of endogenous catecholamines mimics ischemic preconditioning. Bankwala, Z., Hale, S.L., Kloner, R.A. Circulation (1994) [Pubmed]
  29. The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene. Guo, Y., Jones, W.K., Xuan, Y.T., Tang, X.L., Bao, W., Wu, W.J., Han, H., Laubach, V.E., Ping, P., Yang, Z., Qiu, Y., Bolli, R. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  30. Low-dose TNF-alpha protects against hepatic ischemia-reperfusion injury in mice: implications for preconditioning. Teoh, N., Leclercq, I., Pena, A.D., Farrell, G. Hepatology (2003) [Pubmed]
  31. Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation. Miao, B., Yin, X.H., Pei, D.S., Zhang, Q.G., Zhang, G.Y. J. Biol. Chem. (2005) [Pubmed]
  32. Does ischemic preconditioning in the human involve protein kinase C and the ATP-dependent K+ channel? Studies of contractile function after simulated ischemia in an atrial in vitro model. Speechly-Dick, M.E., Grover, G.J., Yellon, D.M. Circ. Res. (1995) [Pubmed]
  33. Sulfhydryl redox state affects susceptibility to ischemia and sarcoplasmic reticulum Ca2+ release in rat heart. Implications for ischemic preconditioning. Zucchi, R., Yu, G., Galbani, P., Mariani, M., Ronca, G., Ronca-Testoni, S. Circ. Res. (1998) [Pubmed]
  34. Effects of 10 minutes of ischemic preconditioning of the cadaveric liver on the graft's preservation and function: the ying and the yang. Azoulay, D., Del Gaudio, M., Andreani, P., Ichai, P., Sebag, M., Adam, R., Scatton, O., Min, B.Y., Delvard, V., Lemoine, A., Bismuth, H., Castaing, D. Ann. Surg. (2005) [Pubmed]
  35. Detection of tumor necrosis factor-alpha mRNA induction in ischemic brain tolerance by means of real-time polymerase chain reaction. Wang, X., Li, X., Erhardt, J.A., Barone, F.C., Feuerstein, G.Z. J. Cereb. Blood Flow Metab. (2000) [Pubmed]
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