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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Facilitation of the induction of long-term potentiation by GABAB receptors.

Long-term potentiation (LTP), an in vitro model of learning, was induced in hippocampal slices by 5-hertz stimulation. During induction, gamma-aminobutyric acid A (GABAA) inhibition decreased, causing the N-methyl-D-aspartate receptor-mediated excitation to increase. 2-OH Saclofen, a GABAB receptor antagonist, prevented the reduction of inhibition, the increase of excitation, and the induction of LTP. Therefore, disinhibition caused by GABAB receptors is required for induction of LTP by 5-hertz stimulation. GABAB receptor modulation of synaptic plasticity occurs at frequencies in the range of the endogenous hippocampal theta rhythm, which has been shown to modulate LTP in vivo.[1]

References

  1. Facilitation of the induction of long-term potentiation by GABAB receptors. Mott, D.D., Lewis, D.V. Science (1991) [Pubmed]
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