Chemical Compound Review:
NMDA (2R)-2-methylaminobutanedioic acid
Synonyms:
N-Me-D-Asp-OH, n-methyl-<scp, Lopac-M-3262, Tocris-0114, CHEMBL291278, ...
Moon Jung Lee,
Choi,
Ji Yoon Lee,
Somjen,
Kee-Won Kim,
Jun-Mo Chung,
Hae Un Lee,
Seok Joon Won,
Young Min Ahn,
Sun Young Ko,
Han Yeol Byun,
Gerald Birk,
Hans-Peter Lipp,
Ji-Hyun Noh,
Holger Rosenbrock,
Wang,
Greengard,
Moran,
Sung Hwa Yoon,
Small,
Davis,
Nong,
Gewirtz,
Kelley,
Daniel Umbricht,
Stephan Bickel,
Snyder,
Stanimirovic,
Carmen Weiss,
Jae-Young Cho,
Sun Ju Son,
Byoung Joo Gwag,
Hye Jin Kwon,
Gouras,
Doo Soon Im,
Hyang Ran Lim,
McEwen,
Ho Sang Moon,
Eliza Koros,
Salter,
Sun Mi Park,
Nairn,
Durkin,
Frank Sams-Dodd,
Sung Ig Cho,
Almeida,
Young Ae Lee,
Bok Sun Yun,
Paul,
Lombroso,
Morley,
- Regulation of NMDA receptors by tyrosine kinases and phosphatases. Wang, Y.T., Salter, M.W. Nature (1994)
- Stress and hippocampal plasticity. McEwen, B.S. Annu. Rev. Neurosci. (1999)
- Activation of NMDA receptors blocks GABAergic inhibition in an in vitro model of epilepsy. Stelzer, A., Slater, N.T., ten Bruggencate, G. Nature (1987)
- Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion. Haberman, R.P., Samulski, R.J., McCown, T.J. Nat. Med. (2003)
- Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Yano, S., Tokumitsu, H., Soderling, T.R. Nature (1998)
- Marked prevention of ischemic brain injury by Neu2000, an NMDA antagonist and antioxidant derived from aspirin and sulfasalazine. Gwag, B.J., Lee, Y.A., Ko, S.Y., Lee, M.J., Im, D.S., Yun, B.S., Lim, H.R., Park, S.M., Byun, H.Y., Son, S.J., Kwon, H.J., Lee, J.Y., Cho, J.Y., Won, S.J., Kim, K.W., Ahn, Y.M., Moon, H.S., Lee, H.U., Yoon, S.H., Noh, J.H., Chung, J.M., Cho, S.I. J. Cereb. Blood Flow Metab. (2007)
- Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's disease. Albin, R.L., Young, A.B., Penney, J.B., Handelin, B., Balfour, R., Anderson, K.D., Markel, D.S., Tourtellotte, W.W., Reiner, A. N. Engl. J. Med. (1990)
- NMDA receptors in the visual cortex of young kittens are more effective than those of adult cats. Tsumoto, T., Hagihara, K., Sato, H., Hata, Y. Nature (1987)
- Mediation of classical conditioning in Aplysia californica by long-term potentiation of sensorimotor synapses. Murphy, G.G., Glanzman, D.L. Science (1997)
- Regulation of NMDA receptor trafficking by amyloid-beta. Snyder, E.M., Nong, Y., Almeida, C.G., Paul, S., Moran, T., Choi, E.Y., Nairn, A.C., Salter, M.W., Lombroso, P.J., Gouras, G.K., Greengard, P. Nat. Neurosci. (2005)
- Memory and addiction: shared neural circuitry and molecular mechanisms. Kelley, A.E. Neuron (2004)
- Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. Somjen, G.G. Physiol. Rev. (2001)
- Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit. Ehlers, M.D., Zhang, S., Bernhadt, J.P., Huganir, R.L. Cell (1996)
- Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice. Li, Y., Erzurumlu, R.S., Chen, C., Jhaveri, S., Tonegawa, S. Cell (1994)
- Glycine binding primes NMDA receptor internalization. Nong, Y., Huang, Y.Q., Ju, W., Kalia, L.V., Ahmadian, G., Wang, Y.T., Salter, M.W. Nature (2003)
- Novel neural modulators. Boehning, D., Snyder, S.H. Annu. Rev. Neurosci. (2003)
- Potentiation of NMDA receptor currents by arachidonic acid. Miller, B., Sarantis, M., Traynelis, S.F., Attwell, D. Nature (1992)
- AMPA receptor-mediated regulation of a Gi-protein in cortical neurons. Wang, Y., Small, D.L., Stanimirovic, D.B., Morley, P., Durkin, J.P. Nature (1997)
- Neurons containing NADPH-diaphorase are selectively resistant to quinolinate toxicity. Koh, J.Y., Peters, S., Choi, D.W. Science (1986)
- Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice. Moechars, D., Lorent, K., De Strooper, B., Dewachter, I., Van Leuven, F. EMBO J. (1996)
- Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder. Woo, T.U., Walsh, J.P., Benes, F.M. Arch. Gen. Psychiatry (2004)
- The selective mGlu5 receptor antagonist MTEP, similar to NMDA receptor antagonists, induces social isolation in rats. Koros, E., Rosenbrock, H., Birk, G., Weiss, C., Sams-Dodd, F. Neuropsychopharmacology (2007)
- Spatial learning without NMDA receptor-dependent long-term potentiation. Saucier, D., Cain, D.P. Nature (1995)
- Regulation of NMDA receptor desensitization in mouse hippocampal neurons by glycine. Mayer, M.L., Vyklicky, L., Clements, J. Nature (1989)
- Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord. Li, P., Wilding, T.J., Kim, S.J., Calejesan, A.A., Huettner, J.E., Zhuo, M. Nature (1999)
- Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase. Lieberman, D.N., Mody, I. Nature (1994)
- Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus. Bashir, Z.I., Alford, S., Davies, S.N., Randall, A.D., Collingridge, G.L. Nature (1991)
- Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism. Herron, C.E., Lester, R.A., Coan, E.J., Collingridge, G.L. Nature (1986)
- NMDA receptors and activity-dependent tuning of the receptive fields of spinal cord neurons. Lewin, G.R., Mckintosh, E., McMahon, S.B. Nature (1994)
- Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Chatterton, J.E., Awobuluyi, M., Premkumar, L.S., Takahashi, H., Talantova, M., Shin, Y., Cui, J., Tu, S., Sevarino, K.A., Nakanishi, N., Tong, G., Lipton, S.A., Zhang, D. Nature (2002)
- Second-order fear conditioning prevented by blocking NMDA receptors in amygdala. Gewirtz, J.C., Davis, M. Nature (1997)
- An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine? Thomson, A.M., West, D.C., Lodge, D. Nature (1985)
- NMDA-receptor regulation of substance P release from primary afferent nociceptors. Liu, H., Mantyh, P.W., Basbaum, A.I. Nature (1997)
- Potassium conductances in hippocampal neurons blocked by excitatory amino-acid transmitters. Charpak, S., Gähwiler, B.H., Do, K.Q., Knöpfel, T. Nature (1990)
- Multiple conductance channels in type-2 cerebellar astrocytes activated by excitatory amino acids. Usowicz, M.M., Gallo, V., Cull-Candy, S.G. Nature (1989)
- Glutamate release promotes growth of malignant gliomas. Takano, T., Lin, J.H., Arcuino, G., Gao, Q., Yang, J., Nedergaard, M. Nat. Med. (2001)
- Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortex. Lecourtier, L., Homayoun, H., Tamagnan, G., Moghaddam, B. Biol. Psychiatry (2007)
- Direct inhibitory effect of fluoxetine on N-methyl-D-aspartate receptors in the central nervous system. Szasz, B.K., Mike, A., Karoly, R., Gerevich, Z., Illes, P., Vizi, E.S., Kiss, J.P. Biol. Psychiatry (2007)
- The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors. Martin, A.M., Kuhlmann, C., Trossbach, S., Jaeger, S., Waldron, E., Roebroek, A., Luhmann, H.J., Laatsch, A., Weggen, S., Lessmann, V., Pietrzik, C.U. J. Biol. Chem. (2008)
- Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to CNS white matter. Bakiri, Y., Hamilton, N.B., Káradóttir, R., Attwell, D. Glia (2008)
- Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Das, S., Sasaki, Y.F., Rothe, T., Premkumar, L.S., Takasu, M., Crandall, J.E., Dikkes, P., Conner, D.A., Rayudu, P.V., Cheung, W., Chen, H.S., Lipton, S.A., Nakanishi, N. Nature (1998)
- Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Sheng, M., Cummings, J., Roldan, L.A., Jan, Y.N., Jan, L.Y. Nature (1994)
- Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakmann, B., Seeburg, P.H. Science (1992)
- Subtoxic N-methyl-D-aspartate delayed neuronal death in ischemic brain injury through TrkB receptor- and calmodulin-mediated PI-3K/Akt pathway activation. Xu, J., Zhang, Q.G., Li, C., Zhang, G.Y. Hippocampus (2007)
- Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites. Iida, J., Ishizaki, H., Okamoto-Tanaka, M., Kawata, A., Sumita, K., Ohgake, S., Sato, Y., Yorifuji, H., Nukina, N., Ohashi, K., Mizuno, K., Tsutsumi, T., Mizoguchi, A., Miyoshi, J., Takai, Y., Hata, Y. Mol. Cell. Biol. (2007)
- Early auditory sensory processing deficits in mouse mutants with reduced NMDA receptor function. Bickel, S., Lipp, H.P., Umbricht, D. Neuropsychopharmacology (2008)
- NMDA receptors of dentate gyrus granule cells participate in synaptic transmission following kindling. Mody, I., Heinemann, U. Nature (1987)
- Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain. Tingley, W.G., Roche, K.W., Thompson, A.K., Huganir, R.L. Nature (1993)
- NMDA receptor-mediated K+ efflux and neuronal apoptosis. Yu, S.P., Yeh, C., Strasser, U., Tian, M., Choi, D.W. Science (1999)
- Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition. Zheng, F., Gingrich, M.B., Traynelis, S.F., Conn, P.J. Nat. Neurosci. (1998)