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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling.

SH2 domains are interaction modules uniquely dedicated to the recognition of phosphotyrosine sites and are embedded in proteins that couple protein-tyrosine kinases to intracellular signaling pathways. Here, we report a comprehensive bioinformatics, structural, and functional view of the human and mouse complement of SH2 domain proteins. This information delimits the set of SH2-containing effectors available for PTK signaling and will facilitate the systems-level analysis of pTyr-dependent protein-protein interactions and PTK-mediated signal transduction. The domain-based architecture of SH2-containing proteins is of more general relevance for understanding the large family of protein interaction domains and the modular organization of the majority of human proteins.[1]

References

  1. The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling. Liu, B.A., Jablonowski, K., Raina, M., Arcé, M., Pawson, T., Nash, P.D. Mol. Cell (2006) [Pubmed]
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