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Chemical Compound Review

sulfaniumyl     sulfur(+1) dihydride cation

Synonyms: CHEBI:29324, H2S(.+), [SH2](.+), dihydridosulfur(.1+)
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Disease relevance of sulfaniumyl


Psychiatry related information on sulfaniumyl

  • Considerably lower H2S levels are reported in the brains of Alzheimer's disease (AD) patients, where levels of brain protein nitration (probably mediated by peroxynitrite) are markedly increased [5].
  • To address this further we assessed olfaction by three methods-a smell identification test ("UPSIT") in 58 patients and 135 controls; olfactory-evoked response (OEP) to H2S in 15 patients, and pathological examination of olfactory bulbs obtained from 8 cadavers [6].
  • The logistic regression was analyzed for estimation of the association between an organoleptic evaluation greater than a slight level and the groups with CH3SH, H2S or total VSC with concentrations above the optimum cut-off value [7].
  • We observed significant reductions in motor activity, water maze performance, and body temperature following exposure only to high concentrations (> or = 80 ppm) of H2S [8].

High impact information on sulfaniumyl

  • The HNC, H2CO, H2S, and CS abundances relative to H2O measured during breakup are consistent with those obtained in other comets [9].
  • CONCLUSIONS: The ability of bismuth subsalicylate to dramatically reduce H2S could provide a clinically useful means of controlling fecal and/or flatus odor and of decreasing the putative injurious effects of H2S on the colonic mucosa [1].
  • Both S0 and polysulfide served as substrates for H2S production, and the S0 reduction activity but not the H2-oxidation activity was enhanced by the redox protein rubredoxin [10].
  • In conclusion, CSE-derived H2S is involved in the maintenance of portal venous pressure [2].
  • We also show that physiological concentrations of H2S selectively enhance NMDA receptor-mediated responses and facilitate the induction of hippocampal long-term potentiation [11].

Chemical compound and disease context of sulfaniumyl


Biological context of sulfaniumyl


Anatomical context of sulfaniumyl


Associations of sulfaniumyl with other chemical compounds


Gene context of sulfaniumyl


Analytical, diagnostic and therapeutic context of sulfaniumyl

  • We expressed and purified corresponding peptides, H1S and H2S, and confirmed by circular dichroism spectroscopy that they can assume alpha-helical conformation [31].
  • Using RT-PCR, only cystathionine gamma-lyase (CSE), a H2S producing enzyme, was detected in primary cultures of microglia [22].
  • In contrast, castration of male mice decreases the levels of testosterone, SAM and H2S in the brain [32].
  • Gradients of O2, H2S, and pH were examined with microelectrodes during incubation [33].
  • In conclusion, our findings provide the first evidence that H2S may protect the heart most probably by activating sarcolemmal KATP channels and/or provoking NO release and the cardioprotective effects of metabolic ischemic preconditioning is, at least partially, mediated by endogenous H2S [34].


  1. Bismuth subsalicylate markedly decreases hydrogen sulfide release in the human colon. Suarez, F.L., Furne, J.K., Springfield, J., Levitt, M.D. Gastroenterology (1998) [Pubmed]
  2. The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis. Fiorucci, S., Antonelli, E., Mencarelli, A., Orlandi, S., Renga, B., Rizzo, G., Distrutti, E., Shah, V., Morelli, A. Hepatology (2005) [Pubmed]
  3. Role of D-cysteine desulfhydrase in the adaptation of Escherichia coli to D-cysteine. Soutourina, J., Blanquet, S., Plateau, P. J. Biol. Chem. (2001) [Pubmed]
  4. High plasma cyst(e)ine level may indicate poor clinical outcome in patients with acute stroke: possible involvement of hydrogen sulfide. Wong, P.T., Qu, K., Chimon, G.N., Seah, A.B., Chang, H.M., Wong, M.C., Ng, Y.K., Rumpel, H., Halliwell, B., Chen, C.P. J. Neuropathol. Exp. Neurol. (2006) [Pubmed]
  5. The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'? Whiteman, M., Armstrong, J.S., Chu, S.H., Jia-Ling, S., Wong, B.S., Cheung, N.S., Halliwell, B., Moore, P.K. J. Neurochem. (2004) [Pubmed]
  6. Olfactory disorder in motor neuron disease. Hawkes, C.H., Shephard, B.C., Geddes, J.F., Body, G.D., Martin, J.E. Exp. Neurol. (1998) [Pubmed]
  7. The assessment of methyl mercaptan, an important clinical marker for the diagnosis of oral malodor. Awano, S., Koshimune, S., Kurihara, E., Gohara, K., Sakai, A., Soh, I., Hamasaki, T., Ansai, T., Takehara, T. Journal of dentistry. (2004) [Pubmed]
  8. Neurotoxicological effects associated with short-term exposure of Sprague-Dawley rats to hydrogen sulfide. Struve, M.F., Brisbois, J.N., James, R.A., Marshall, M.W., Dorman, D.C. Neurotoxicology (2001) [Pubmed]
  9. Outgassing behavior and composition of comet C/1999 S4 (LINEAR) during its disruption. Bockelée-Morvan, D., Biver, N., Moreno, R., Colom, P., Crovisier, J., Gérard, E., Henry, F., Lis, D.C., Matthews, H., Weaver, H.A., Womack, M., Festou, M.C. Science (2001) [Pubmed]
  10. Hydrogenase of the hyperthermophile Pyrococcus furiosus is an elemental sulfur reductase or sulfhydrogenase: evidence for a sulfur-reducing hydrogenase ancestor. Ma, K., Schicho, R.N., Kelly, R.M., Adams, M.W. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  11. The possible role of hydrogen sulfide as an endogenous neuromodulator. Abe, K., Kimura, H. J. Neurosci. (1996) [Pubmed]
  12. Single eubacterial origin of eukaryotic sulfide:quinone oxidoreductase, a mitochondrial enzyme conserved from the early evolution of eukaryotes during anoxic and sulfidic times. Theissen, U., Hoffmeister, M., Grieshaber, M., Martin, W. Mol. Biol. Evol. (2003) [Pubmed]
  13. Anaerobic sulfide oxidation with nitrate by a freshwater Beggiatoa enrichment culture. Kamp, A., Stief, P., Schulz-Vogt, H.N. Appl. Environ. Microbiol. (2006) [Pubmed]
  14. The phs gene and hydrogen sulfide production by Salmonella typhimurium. Clark, M.A., Barrett, E.L. J. Bacteriol. (1987) [Pubmed]
  15. Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia. Collin, M., Anuar, F.B., Murch, O., Bhatia, M., Moore, P.K., Thiemermann, C. Br. J. Pharmacol. (2005) [Pubmed]
  16. Role of hydrosulfide ions (HS-) in methylmercury resistance in Saccharomyces cerevisiae. Ono, B., Ishii, N., Fujino, S., Aoyama, I. Appl. Environ. Microbiol. (1991) [Pubmed]
  17. Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine. Chen, X., Jhee, K.H., Kruger, W.D. J. Biol. Chem. (2004) [Pubmed]
  18. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1. Yang, G., Cao, K., Wu, L., Wang, R. J. Biol. Chem. (2004) [Pubmed]
  19. Hydrogen sulphide and the hyperdynamic circulation in cirrhosis: a hypothesis. Ebrahimkhani, M.R., Mani, A.R., Moore, K. Gut (2005) [Pubmed]
  20. Direct stimulation of K(ATP) channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells. Tang, G., Wu, L., Liang, W., Wang, R. Mol. Pharmacol. (2005) [Pubmed]
  21. Regulation of sulfur nutrition in wild-type and transgenic poplar over-expressing gamma-glutamylcysteine synthetase in the cytosol as affected by atmospheric H2S. Herschbach, C., van Der Zalm, E., Schneider, A., Jouanin, L., De Kok, L.J., Rennenberg, H. Plant Physiol. (2000) [Pubmed]
  22. Hydrogen sulphide regulates calcium homeostasis in microglial cells. Lee, S.W., Hu, Y.S., Hu, L.F., Lu, Q., Dawe, G.S., Moore, P.K., Wong, P.T., Bian, J.S. Glia (2006) [Pubmed]
  23. Effect of Tyrosyl modifications on nucleosome reconstitution: a spin-labeling study. Chan, D.C., Piette, L.H. Biochemistry (1982) [Pubmed]
  24. The role of hydrogen sulfide generation in the pathogenesis of hypertension in rats induced by inhibition of nitric oxide synthase. Zhong, G., Chen, F., Cheng, Y., Tang, C., Du, J. J. Hypertens. (2003) [Pubmed]
  25. Quenching of room temperature protein phosphorescence by added small molecules. Calhoun, D.B., Englander, S.W., Wright, W.W., Vanderkooi, J.M. Biochemistry (1988) [Pubmed]
  26. Regulatory properties of O-acetyl-L-serine sulfhydrylase of Cephalosporium acremonium: evidence of an isoenzyme and its importance in cephalosporin C biosynthesis. Döbeli, H., Nüesch, J. Antimicrob. Agents Chemother. (1980) [Pubmed]
  27. Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3. Yang, G., Sun, X., Wang, R. FASEB J. (2004) [Pubmed]
  28. Molecular mechanisms of hydrogen sulfide toxicity*. Truong, D.H., Eghbal, M.A., Hindmarsh, W., Roth, S.H., O'brien, P.J. Drug Metab. Rev. (2006) [Pubmed]
  29. Hydrogen sulfide as a neuromodulator. Kimura, H. Mol. Neurobiol. (2002) [Pubmed]
  30. Inhibition of oxytocin-induced but not angiotensin-induced rat uterine contractions following exposure to sodium sulfide. Hayden, L.J., Franklin, K.J., Roth, S.H., Moore, G.J. Life Sci. (1989) [Pubmed]
  31. The oligomerization domain of the asialoglycoprotein receptor preferentially forms 2:2 heterotetramers in vitro. Bider, M.D., Wahlberg, J.M., Kammerer, R.A., Spiess, M. J. Biol. Chem. (1996) [Pubmed]
  32. The production of hydrogen sulfide is regulated by testosterone and S-adenosyl-L-methionine in mouse brain. Eto, K., Kimura, H. J. Neurochem. (2002) [Pubmed]
  33. Distribution of sulfate-reducing bacteria, O2, and H2S in photosynthetic biofilms determined by oligonucleotide probes and microelectrodes. Ramsing, N.B., Kühl, M., Jørgensen, B.B. Appl. Environ. Microbiol. (1993) [Pubmed]
  34. Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes. Pan, T.T., Feng, Z.N., Lee, S.W., Moore, P.K., Bian, J.S. J. Mol. Cell. Cardiol. (2006) [Pubmed]
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