Isolation of a family of Drosophila POU domain genes expressed in early development.
The POU domain is a approximately 140 amino acid domain shared by several mammalian transcriptional activators. We have isolated genomic and cDNA clones from three Drosophila POU domain genes, designated pdm-1, pdm-2, and Cf1a. All three genes encode a conserved POU-specific domain and a POU homeo domain but are otherwise divergent. By Northern analysis, all three of the genes are expressed in early embryos; the pdm-1 and Cf1a genes are also expressed at lower levels throughout development. The spatial expression patterns of the pdm-2 and Cf1a genes show that they probably play multiple roles during development: an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system.[1]References
- Isolation of a family of Drosophila POU domain genes expressed in early development. Billin, A.N., Cockerill, K.A., Poole, S.J. Mech. Dev. (1991) [Pubmed]
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