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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Functional roles of the gamma subunit of the skeletal muscle DHP-receptor.

In excitation-contraction coupling (EC coupling) of skeletal muscle, large and rapid changes of the myoplasmic Ca(2+) concentration mediate the activation and termination of force. The L-type Ca(2+) channel (dihydropyridine receptor, DHP receptor) is a central component of the EC coupling process. Its predominant role is to provide the Ca(2+) release channels of the sarcoplasmic reticulum (SR) with the sensitivity to cell membrane voltage. The DHP receptor consists of five different proteins (alpha(1S), beta(1), gamma(1), delta and alpha(2)) whose tasks and functional characteristics are still incompletely understood. This short review summarizes progress made in studying the physiology of the gamma(1) subunit, a membrane polypeptide that is highly specific for skeletal muscle. The focus is on recent results obtained from muscle of gamma(1)-deficient mice.[1]


  1. Functional roles of the gamma subunit of the skeletal muscle DHP-receptor. Melzer, W., Andronache, Z., Ursu, D. J. Muscle Res. Cell. Motil. (2006) [Pubmed]
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