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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Monoclonal antibodies against defined regions of the muscular dystrophy protein, dystrophin.

Nineteen monoclonal antibodies which bind to native dystrophin in the plasma membrane of frozen muscle sections were obtained using a recombinant fusion protein as immunogen. On Western blots of normal mouse muscle extracts, the antibodies bind specifically to a 400,000 Mr protein which is absent from dystrophic mouse (mdx) muscle. At least four distinct epitopes have been identified by cleavage mapping methods. Although the fusion protein contained 25% of the human dystrophin sequence (Cys816-Asp1747; Mr 108,000), most of the monoclonal antibodies (15 out of 19) recognize a single fragment of Mr 27,500.[1]

References

  1. Monoclonal antibodies against defined regions of the muscular dystrophy protein, dystrophin. Nguyen thi Man, n.u.l.l., Cartwright, A.J., Morris, G.E., Love, D.R., Bloomfield, J.F., Davies, K.E. FEBS Lett. (1990) [Pubmed]
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