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Inouye, M.

Inouye,

Signaling by transmembrane proteins shifts gears.

The HAMP domain is present in a large number of transmembrane proteins in prokaryotes including histidine kinases, adenylyl cyclases, chemotaxis receptors, and phosphatases. In this issue of Cell, report the NMR structure of a HAMP domain and present data suggesting that it transduces signals through a simple rotation of its four-helix parallel coiled coil.[1]

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Signaling by transmembrane proteins shifts gears. Inouye, M. Cell (2006) [Pubmed]

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