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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Karyotype complexity and VH gene status in B-cell chronic lymphocytic leukemia.

B-cell chronic lymphocytic leukemia-related genomic changes were analyzed by karyotyping, fluorescence in situ hybridization, and VH gene sequencing in a prospective clinical evaluation. The VH mutational status correlated with high-risk cytogenetic aberrations while no such relation could be demonstrated for specific VH gene usage (V3-21 and V1-69). Complex karyotypes were highly indicative of disease progression.[1]

References

  1. Karyotype complexity and VH gene status in B-cell chronic lymphocytic leukemia. M??hes, G., Kov??cs, G., Kajt??r, B., Lacza, A., V??rnai, A., Losonczy, H., Pajor, L. Haematologica (2006) [Pubmed]
 
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