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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Disease Progression

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Disease relevance of Disease Progression


Psychiatry related information on Disease Progression


High impact information on Disease Progression


Chemical compound and disease context of Disease Progression


Biological context of Disease Progression


Anatomical context of Disease Progression


Gene context of Disease Progression

  • Thus, the protective effect of delta ccr5 against disease progression is lost when the infecting virus uses CXCR-4 as a coreceptor [20].
  • A more commonly distributed transition causing a valine to isoleucine switch in transmembrane domain I of CCR2B (64I) with unknown functional consequences was recently shown to delay disease progression but not reduce infection risk [30].
  • Inhibition of VEGF receptor Flk1 did not affect arthritis or atherosclerosis, indicating that inhibition of Flk1-driven angiogenesis alone was not sufficient to halt disease progression [31].
  • Amounts of MGAT5 glycan products are commonly increased in malignancies, and correlate with disease progression [32].
  • Genetic alterations in the TP53 gene have been reported as frequent events in bladder cancer and are associated with disease progression [33].
  • GADAs persist for 6 years after diagnosis of LADA, but levels and reactivity to different GAD65 epitopes are not associated with disease progression [34].

Analytical, diagnostic and therapeutic context of Disease Progression


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  6. Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Ona, V.O., Li, M., Vonsattel, J.P., Andrews, L.J., Khan, S.Q., Chung, W.M., Frey, A.S., Menon, A.S., Li, X.J., Stieg, P.E., Yuan, J., Penney, J.B., Young, A.B., Cha, J.H., Friedlander, R.M. Nature (1999) [Pubmed]
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  9. Protection against osteoporosis by active immunization with TRANCE/RANKL displayed on virus-like particles. Spohn, G., Schwarz, K., Maurer, P., Illges, H., Rajasekaran, N., Choi, Y., Jennings, G.T., Bachmann, M.F. J. Immunol. (2005) [Pubmed]
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  11. Disruption of DAG1 in differentiated skeletal muscle reveals a role for dystroglycan in muscle regeneration. Cohn, R.D., Henry, M.D., Michele, D.E., Barresi, R., Saito, F., Moore, S.A., Flanagan, J.D., Skwarchuk, M.W., Robbins, M.E., Mendell, J.R., Williamson, R.A., Campbell, K.P. Cell (2002) [Pubmed]
  12. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group. Matthay, K.K., Villablanca, J.G., Seeger, R.C., Stram, D.O., Harris, R.E., Ramsay, N.K., Swift, P., Shimada, H., Black, C.T., Brodeur, G.M., Gerbing, R.B., Reynolds, C.P. N. Engl. J. Med. (1999) [Pubmed]
  13. Chlorambucil in indolent chronic lymphocytic leukemia. French Cooperative Group on Chronic Lymphocytic Leukemia. Dighiero, G., Maloum, K., Desablens, B., Cazin, B., Navarro, M., Leblay, R., Leporrier, M., Jaubert, J., Lepeu, G., Dreyfus, B., Binet, J.L., Travade, P. N. Engl. J. Med. (1998) [Pubmed]
  14. Zidovudine alone or in combination with didanosine or zalcitabine in HIV-infected patients with the acquired immunodeficiency syndrome or fewer than 200 CD4 cells per cubic millimeter. Investigators for the Terry Beirn Community Programs for Clinical Research on AIDS. Saravolatz, L.D., Winslow, D.L., Collins, G., Hodges, J.S., Pettinelli, C., Stein, D.S., Markowitz, N., Reves, R., Loveless, M.O., Crane, L., Thompson, M., Abrams, D. N. Engl. J. Med. (1996) [Pubmed]
  15. Diet, lipoproteins, and the progression of coronary atherosclerosis. The Leiden Intervention Trial. Arntzenius, A.C., Kromhout, D., Barth, J.D., Reiber, J.H., Bruschke, A.V., Buis, B., van Gent, C.M., Kempen-Voogd, N., Strikwerda, S., van der Velde, E.A. N. Engl. J. Med. (1985) [Pubmed]
  16. High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison. Moertel, C.G., Fleming, T.R., Creagan, E.T., Rubin, J., O'Connell, M.J., Ames, M.M. N. Engl. J. Med. (1985) [Pubmed]
  17. Protective effect of the bispiperazinedione ICRF-187 against doxorubicin-induced cardiac toxicity in women with advanced breast cancer. Speyer, J.L., Green, M.D., Kramer, E., Rey, M., Sanger, J., Ward, C., Dubin, N., Ferrans, V., Stecy, P., Zeleniuch-Jacquotte, A. N. Engl. J. Med. (1988) [Pubmed]
  18. Unraveling the mechanisms involved in motor neuron degeneration in ALS. Bruijn, L.I., Miller, T.M., Cleveland, D.W. Annu. Rev. Neurosci. (2004) [Pubmed]
  19. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Chen, M., Ona, V.O., Li, M., Ferrante, R.J., Fink, K.B., Zhu, S., Bian, J., Guo, L., Farrell, L.A., Hersch, S.M., Hobbs, W., Vonsattel, J.P., Cha, J.H., Friedlander, R.M. Nat. Med. (2000) [Pubmed]
  20. The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression. Michael, N.L., Chang, G., Louie, L.G., Mascola, J.R., Dondero, D., Birx, D.L., Sheppard, H.W. Nat. Med. (1997) [Pubmed]
  21. Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients. Pei, Y., Scholey, J., Thai, K., Suzuki, M., Cattran, D. J. Clin. Invest. (1997) [Pubmed]
  22. Lack of high-affinity nerve growth factor receptors in aggressive neuroblastomas. Suzuki, T., Bogenmann, E., Shimada, H., Stram, D., Seeger, R.C. J. Natl. Cancer Inst. (1993) [Pubmed]
  23. Zidovudine resistance and HIV-1 disease progression during antiretroviral therapy. AIDS Clinical Trials Group Protocol 116B/117 Team and the Virology Committee Resistance Working Group. D'Aquila, R.T., Johnson, V.A., Welles, S.L., Japour, A.J., Kuritzkes, D.R., DeGruttola, V., Reichelderfer, P.S., Coombs, R.W., Crumpacker, C.S., Kahn, J.O., Richman, D.D. Ann. Intern. Med. (1995) [Pubmed]
  24. Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease. Tao, Y., Kim, J., Faubel, S., Wu, J.C., Falk, S.A., Schrier, R.W., Edelstein, C.L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  25. Coinfection with human T-cell lymphotropic virus type I and HIV in Brazil. Impact on markers of HIV disease progression. Schechter, M., Harrison, L.H., Halsey, N.A., Trade, G., Santino, M., Moulton, L.H., Quinn, T.C. JAMA (1994) [Pubmed]
  26. HIV-1 protease inhibitors. A review for clinicians. Deeks, S.G., Smith, M., Holodniy, M., Kahn, J.O. JAMA (1997) [Pubmed]
  27. Activity of P-glycoprotein in B-cell chronic lymphocytic leukemia determined by a flow cytometric assay. Ludescher, C., Hilbe, W., Eisterer, W., Preuss, E., Huber, C., Gotwald, M., Hofmann, J., Thaler, J. J. Natl. Cancer Inst. (1993) [Pubmed]
  28. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. Shivakumar, P., Campbell, K.M., Sabla, G.E., Miethke, A., Tiao, G., McNeal, M.M., Ward, R.L., Bezerra, J.A. J. Clin. Invest. (2004) [Pubmed]
  29. p53 expression in B-cell chronic lymphocytic leukemia: a marker of disease progression and poor prognosis. Cordone, I., Masi, S., Mauro, F.R., Soddu, S., Morsilli, O., Valentini, T., Vegna, M.L., Guglielmi, C., Mancini, F., Giuliacci, S., Sacchi, A., Mandelli, F., Foa, R. Blood (1998) [Pubmed]
  30. The role of CCR5 and CCR2 polymorphisms in HIV-1 transmission and disease progression. Michael, N.L., Louie, L.G., Rohrbaugh, A.L., Schultz, K.A., Dayhoff, D.E., Wang, C.E., Sheppard, H.W. Nat. Med. (1997) [Pubmed]
  31. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Luttun, A., Tjwa, M., Moons, L., Wu, Y., Angelillo-Scherrer, A., Liao, F., Nagy, J.A., Hooper, A., Priller, J., De Klerck, B., Compernolle, V., Daci, E., Bohlen, P., Dewerchin, M., Herbert, J.M., Fava, R., Matthys, P., Carmeliet, G., Collen, D., Dvorak, H.F., Hicklin, D.J., Carmeliet, P. Nat. Med. (2002) [Pubmed]
  32. Suppression of tumor growth and metastasis in Mgat5-deficient mice. Granovsky, M., Fata, J., Pawling, J., Muller, W.J., Khokha, R., Dennis, J.W. Nat. Med. (2000) [Pubmed]
  33. Altered patterns of MDM2 and TP53 expression in human bladder cancer. Lianes, P., Orlow, I., Zhang, Z.F., Oliva, M.R., Sarkis, A.S., Reuter, V.E., Cordon-Cardo, C. J. Natl. Cancer Inst. (1994) [Pubmed]
  34. GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Desai, M., Cull, C.A., Horton, V.A., Christie, M.R., Bonifacio, E., Lampasona, V., Bingley, P.J., Levy, J.C., Mackay, I.R., Zimmet, P., Holman, R.R., Clark, A. Diabetologia (2007) [Pubmed]
  35. A randomized, double-blind trial comparing combinations of nevirapine, didanosine, and zidovudine for HIV-infected patients: the INCAS Trial. Italy, The Netherlands, Canada and Australia Study. Montaner, J.S., Reiss, P., Cooper, D., Vella, S., Harris, M., Conway, B., Wainberg, M.A., Smith, D., Robinson, P., Hall, D., Myers, M., Lange, J.M. JAMA (1998) [Pubmed]
  36. Rates of disease progression by baseline CD4 cell count and viral load after initiating triple-drug therapy. Hogg, R.S., Yip, B., Chan, K.J., Wood, E., Craib, K.J., O'Shaughnessy, M.V., Montaner, J.S. JAMA (2001) [Pubmed]
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  38. An N-glucosylated peptide detecting disease-specific autoantibodies, biomarkers of multiple sclerosis. Lolli, F., Mulinacci, B., Carotenuto, A., Bonetti, B., Sabatino, G., Mazzanti, B., D'Ursi, A.M., Novellino, E., Pazzagli, M., Lovato, L., Alcaro, M.C., Peroni, E., Pozo-Carrero, M.C., Nuti, F., Battistini, L., Borsellino, G., Chelli, M., Rovero, P., Papini, A.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  39. Transplanted ALDHhiSSClo neural stem cells generate motor neurons and delay disease progression of nmd mice, an animal model of SMARD1. Corti, S., Locatelli, F., Papadimitriou, D., Donadoni, C., Del Bo, R., Crimi, M., Bordoni, A., Fortunato, F., Strazzer, S., Menozzi, G., Salani, S., Bresolin, N., Comi, G.P. Hum. Mol. Genet. (2006) [Pubmed]
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