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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Association of a hypothalamic pituitary adrenocortical axis regulatory factor, T-box19.

Neurotic personality traits are important factors in several psychiatric disorders and suicidal behavior. Here, we have investigated the existence of potential relationships between neurotic personality traits and genetic variation. Non-suicidal parents derived from trios (suicide attempter and both parents) and non-suicidal volunteers, examined by the NEO Personality Inventory-Revised (N EO PI-R), were divided into screening and replication samples. The screening sample (n=127) was used to select potential relationships between neurotic personality traits and genetic variation among 130 single nucleotide polymorphisms (SNPs). Screening (ANOVA) with regard to the personality dimension Neuroticism, indicated potential relationships at three different loci. More detailed analysis of these three SNPs at facet-level indicated four potential relationships. T-test analysis in the replication sample (n=617) was used to retest the relationships indicated during screening. One of those relationships was confirmed in the replication sample (P=0.0052, Bonferroni correction), indicating that genetic variation at the human T-box 19 (TBX19) locus is related to the personality trait angry hostility. Furthermore, using analysis of haplotypes among trios (n=219) by transmission disequilibrium test (TDT), a strong tendency for over-transmission of a haplotype C-G-A was found a t the TBX19 locus, among suicide attempters with high angry hostility scores.[1]

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