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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Puellmann, K. et al.

Puellmann, Kaminski, Vogel, Nebe, Schroeder, Wolf, Beham,

From the Cover: A variable immunoreceptor in a subpopulation of human neutrophils.

Neutrophils are thought to rely solely on nonspecific immune mechanisms. Here we provide molecular biological, immunological, ultrastructural, and functional evidence for the presence of a T cell receptor (TCR)-based variable immunoreceptor in a 5-8% subpopulation of human neutrophils. We demonstrate that these peripheral blood neutrophils express variable and individual-specific TCRalphabeta repertoires and the RAG1/RAG2 recombinase complex. The proinflammatory cytokine granulocyte colony-stimulating factor regulates expression of the neutrophil immunoreceptor and RAG1/RAG2 in vivo. Specific engagement of the neutrophil TCR complex protects from apoptosis and stimulates secretion of the neutrophil-activating chemokine IL-8. Our results, which also demonstrate the presence of the TCR in murine neutrophils, suggest the coexistence of a variable and an innate host defense system in mammalian neutrophils.[1]

References

From the Cover: A variable immunoreceptor in a subpopulation of human neutrophils. Puellmann, K., Kaminski, W.E., Vogel, M., Nebe, C.T., Schroeder, J., Wolf, H., Beham, A.W. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]

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