The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Granulocytes


Psychiatry related information on Granulocytes


High impact information on Granulocytes

  • UDP-galactose ceramide galactosyltransferase-deficient (Cgt(-/-)) mice exhibit aberrant nerve conduction and display virtually no HSPC egress from BM following granulocyte colony-stimulating factor (G-CSF) or fucoidan administration [10].
  • Conditional expression of C/EBPalpha triggers neutrophilic differentiation, and no mature granulocytes are observed in Cebpa-mutant mice [11].
  • Among the identified candidate genes is the gene encoding nonmuscle myosin heavy chain 9 (MYH9; refs 8-10), which is expressed in platelets and upregulated during granulocyte differentiation [12].
  • Therapy with granulocyte colony stimulating factor was more frequent in the ganciclovir group (24 percent) than in the placebo group (9 percent) [13].
  • We show here that the transmembrane form of TNF is superior to soluble TNF in activating TNFR80 in various systems such as T cell activation, thymocyte proliferation, and granulocyte/macrophage colony-stimulating factor production [14].

Chemical compound and disease context of Granulocytes

  • Exogenous superoxide dismutase (10 micrograms/ml) inhibited granulocyte toxicity for egg metabolic activity (3.0 +/- 2.1% reduction in acetate metabolism vs. 28.3 +/- 0.9% decrease in controls without superoxide dismutase, P less than 0.0005) and hatching (12.5 +/- 1.8% reduction, P less than 0.0005), whereas catalase and heparin had no effect [15].
  • Tumor necrosis factor downregulates granulocyte-colony-stimulating factor receptor expression on human acute myeloid leukemia cells and granulocytes [16].
  • To test this hypothesis, we prepared Escherichia coli labeled with [3H]arginine and treated these bacteria with a lipid-soluble, active-site-directed chloromethyl ketone inactivator of pancreatic and granulocyte elastases (carbobenzoxy-L-glycyl-L-leucyl-L-alanine chloromethyl ketone, dissolved in methanol) [17].
  • To investigate the nature of this protection, dogs and rabbits were immunized with purified glycolipid prepared by phenol-chloroform-petroleum ether extraction of the "Re" mutant of Salmonella minnesota 595 and opsonophagocytic and bactericidal tests were carried out using lapine peritoneal granulocytes and serum factors [18].
  • MAb 42/6 also increased toxicity of parabactin to granulocyte/macrophage colony-stimulating factors and normal marrow granulocyte/macrophage progenitors [19].

Biological context of Granulocytes


Anatomical context of Granulocytes


Associations of Granulocytes with chemical compounds


Gene context of Granulocytes


Analytical, diagnostic and therapeutic context of Granulocytes


  1. Treatment of cyclic neutropenia with granulocyte colony-stimulating factor. Hammond, W.P., Price, T.H., Souza, L.M., Dale, D.C. N. Engl. J. Med. (1989) [Pubmed]
  2. Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia. Largaespada, D.A., Brannan, C.I., Jenkins, N.A., Copeland, N.G. Nat. Genet. (1996) [Pubmed]
  3. Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria. Miyata, T., Yamada, N., Iida, Y., Nishimura, J., Takeda, J., Kitani, T., Kinoshita, T. N. Engl. J. Med. (1994) [Pubmed]
  4. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Takahashi, T., Kalka, C., Masuda, H., Chen, D., Silver, M., Kearney, M., Magner, M., Isner, J.M., Asahara, T. Nat. Med. (1999) [Pubmed]
  5. Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice. Lindberg, F.P., Bullard, D.C., Caver, T.E., Gresham, H.D., Beaudet, A.L., Brown, E.J. Science (1996) [Pubmed]
  6. Abnormal G protein alpha(s) - and alpha(i2)-subunit mRNA expression in bipolar affective disorder. Spleiss, O., van Calker, D., Schärer, L., Adamovic, K., Berger, M., Gebicke-Haerter, P.J. Mol. Psychiatry (1998) [Pubmed]
  7. Role of cytoprotective mechanisms in the photochemical purging of autologous bone marrow grafts. Yamazaki, T., Sato, Y., Sieber, F. Exp. Hematol. (1997) [Pubmed]
  8. Increased histamine release and granulocytes within the thalamus of a rat model of Wernicke's encephalopathy. McRee, R.C., Terry-Ferguson, M., Langlais, P.J., Chen, Y., Nalwalk, J.W., Blumenstock, F.A., Hough, L.B. Brain Res. (2000) [Pubmed]
  9. The preterm prediction study: granulocyte colony-stimulating factor and spontaneous preterm birth. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Goldenberg, R.L., Andrews, W.W., Mercer, B.M., Moawad, A.H., Meis, P.J., Iams, J.D., Das, A., Caritis, S.N., Roberts, J.M., Miodovnik, M., Menard, K., Thurnau, G., Dombrowski, M.P., McNellis, D. Am. J. Obstet. Gynecol. (2000) [Pubmed]
  10. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Katayama, Y., Battista, M., Kao, W.M., Hidalgo, A., Peired, A.J., Thomas, S.A., Frenette, P.S. Cell (2006) [Pubmed]
  11. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Pabst, T., Mueller, B.U., Zhang, P., Radomska, H.S., Narravula, S., Schnittger, S., Behre, G., Hiddemann, W., Tenen, D.G. Nat. Genet. (2001) [Pubmed]
  12. Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. The May-Heggllin/Fechtner Syndrome Consortium. Seri, M., Cusano, R., Gangarossa, S., Caridi, G., Bordo, D., Lo Nigro, C., Ghiggeri, G.M., Ravazzolo, R., Savino, M., Del Vecchio, M., d'Apolito, M., Iolascon, A., Zelante, L.L., Savoia, A., Balduini, C.L., Noris, P., Magrini, U., Belletti, S., Heath, K.E., Babcock, M., Glucksman, M.J., Aliprandis, E., Bizzaro, N., Desnick, R.J., Martignetti, J.A. Nat. Genet. (2000) [Pubmed]
  13. Oral ganciclovir for the prevention of cytomegalovirus disease in persons with AIDS. Roche Cooperative Oral Ganciclovir Study Group. Spector, S.A., McKinley, G.F., Lalezari, J.P., Samo, T., Andruczk, R., Follansbee, S., Sparti, P.D., Havlir, D.V., Simpson, G., Buhles, W., Wong, R., Stempien, M. N. Engl. J. Med. (1996) [Pubmed]
  14. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Grell, M., Douni, E., Wajant, H., Löhden, M., Clauss, M., Maxeiner, B., Georgopoulos, S., Lesslauer, W., Kollias, G., Pfizenmaier, K., Scheurich, P. Cell (1995) [Pubmed]
  15. Role of granulocyte oxygen products in damage of Schistosoma mansoni eggs in vitro. Kazura, J.W., de Brito, P., Rabbege, J., Aikawa, M. J. Clin. Invest. (1985) [Pubmed]
  16. Tumor necrosis factor downregulates granulocyte-colony-stimulating factor receptor expression on human acute myeloid leukemia cells and granulocytes. Elbaz, O., Budel, L.M., Hoogerbrugge, H., Touw, I.P., Delwel, R., Mahmoud, L.A., Löwenberg, B. J. Clin. Invest. (1991) [Pubmed]
  17. The role of lysosomal elastase in the digestion of Escherichia coli proteins by human polymorphonuclear leukocytes: experiments with living leukocytes. Blondin, J., Janoff, A. J. Clin. Invest. (1976) [Pubmed]
  18. Functional role of antibody against "core" glycolipid of Enterobacteriaceae. Young, L.S., Stevens, P., Ingram, J. J. Clin. Invest. (1975) [Pubmed]
  19. Combination iron depletion therapy. Taetle, R., Honeysett, J.M., Bergeron, R. J. Natl. Cancer Inst. (1989) [Pubmed]
  20. The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage. Nguyen, H.Q., Hoffman-Liebermann, B., Liebermann, D.A. Cell (1993) [Pubmed]
  21. Expression cloning of a receptor for murine granulocyte colony-stimulating factor. Fukunaga, R., Ishizaka-Ikeda, E., Seto, Y., Nagata, S. Cell (1990) [Pubmed]
  22. Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor. Nagata, S., Tsuchiya, M., Asano, S., Kaziro, Y., Yamazaki, T., Yamamoto, O., Hirata, Y., Kubota, N., Oheda, M., Nomura, H. Nature (1986) [Pubmed]
  23. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nestle, F.O., Alijagic, S., Gilliet, M., Sun, Y., Grabbe, S., Dummer, R., Burg, G., Schadendorf, D. Nat. Med. (1998) [Pubmed]
  24. Compartmentalization of cyclic AMP during phagocytosis by human neutrophilic granulocytes. Pryzwansky, K.B., Steiner, A.L., Spitznagel, J.K., Kapoor, C.L. Science (1981) [Pubmed]
  25. Low-dose chloramphenicol stimulates granulocyte/monocyte colony-forming units. Bostrom, B., Smith, K., Ramsay, N.K. N. Engl. J. Med. (1984) [Pubmed]
  26. Effect of granulocyte colony-stimulating factor after intensive induction therapy in relapsed or refractory acute leukemia. Ohno, R., Tomonaga, M., Kobayashi, T., Kanamaru, A., Shirakawa, S., Masaoka, T., Omine, M., Oh, H., Nomura, T., Sakai, Y. N. Engl. J. Med. (1990) [Pubmed]
  27. Expression of the GM-CSF gene after retroviral transfer in hematopoietic stem cell lines induces synchronous granulocyte-macrophage differentiation. Just, U., Stocking, C., Spooncer, E., Dexter, T.M., Ostertag, W. Cell (1991) [Pubmed]
  28. Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Takeda, J., Miyata, T., Kawagoe, K., Iida, Y., Endo, Y., Fujita, T., Takahashi, M., Kitani, T., Kinoshita, T. Cell (1993) [Pubmed]
  29. Phagocytosis and inflammatory stimuli induce GM-CSF mRNA in macrophages through posttranscriptional regulation. Thorens, B., Mermod, J.J., Vassalli, P. Cell (1987) [Pubmed]
  30. The effect of lithium on murine hematopoiesis in a liquid culture system. Levitt, L.J., Quesenberry, P.J. N. Engl. J. Med. (1980) [Pubmed]
  31. Acute pulmonary decompensation due to amphotericin B in the absence of granulocyte transfusions. Haber, R.H., Oddone, E.Z., Gurbel, P.A., Stead, W.W. N. Engl. J. Med. (1986) [Pubmed]
  32. Increased expression of an adhesion-promoting surface glycoprotein in the granulocytopenia of hemodialysis. Arnaout, M.A., Hakim, R.M., Todd, R.F., Dana, N., Colten, H.R. N. Engl. J. Med. (1985) [Pubmed]
  33. Control of lysozyme induction in the differentiation of myeloid leukemic cells. Krystosek, A., Sachs, L. Cell (1976) [Pubmed]
  34. Protection of granulocytes by vitamin E in glutathione synthetase deficiency. Boxer, L.A., Oliver, J.M., Spielberg, S.P., Allen, J.M., Schulman, J.D. N. Engl. J. Med. (1979) [Pubmed]
  35. Stimulation of multipotential, erythroid and other murine haematopoietic progenitor cells by adherent cell lines in the absence of detectable multi-CSF (IL-3). Li, C.L., Johnson, G.R. Nature (1985) [Pubmed]
  36. Structure and function of a new STAT-induced STAT inhibitor. Naka, T., Narazaki, M., Hirata, M., Matsumoto, T., Minamoto, S., Aono, A., Nishimoto, N., Kajita, T., Taga, T., Yoshizaki, K., Akira, S., Kishimoto, T. Nature (1997) [Pubmed]
  37. Phospholipase D: a downstream effector of ARF in granulocytes. Cockcroft, S., Thomas, G.M., Fensome, A., Geny, B., Cunningham, E., Gout, I., Hiles, I., Totty, N.F., Truong, O., Hsuan, J.J. Science (1994) [Pubmed]
  38. The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors. Goyert, S.M., Ferrero, E., Rettig, W.J., Yenamandra, A.K., Obata, F., Le Beau, M.M. Science (1988) [Pubmed]
  39. Cytokines in chronic inflammatory arthritis. IV. Granulocyte/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: a possible role in rheumatoid arthritis. Alvaro-Gracia, J.M., Zvaifler, N.J., Firestein, G.S. J. Exp. Med. (1989) [Pubmed]
  40. Preliminary results of treatment with filgrastim for relapse of leukemia and myelodysplasia after allogeneic bone marrow transplantation. Giralt, S., Escudier, S., Kantarjian, H., Deisseroth, A., Freireich, E.J., Andersson, B.S., O'Brien, S., Andreeff, M., Fisher, H., Cork, A. N. Engl. J. Med. (1993) [Pubmed]
  41. Different stromal cell lines support lineage-selective differentiation of the multipotential bone marrow stem cell clone LyD9. Lee, K.H., Kinashi, T., Tohyama, K., Tashiro, K., Funato, N., Hama, K., Honjo, T. J. Exp. Med. (1991) [Pubmed]
  42. Complement-mediated phagocytosis of herpes simplex virus by granulocytes. Binding or ingestion. Van Strijp, J.A., Van Kessel, K.P., van der Tol, M.E., Verhoef, J. J. Clin. Invest. (1989) [Pubmed]
  43. Gut inflammation in children with cystic fibrosis on high-dose enzyme supplements. Croft, N.M., Marshall, T.G., Ferguson, A. Lancet (1995) [Pubmed]
  44. Prediction of azathioprine intolerance in transplant patients. Fisher, K.A., Mahajan, S.K., Hill, J.L., Stuart, F.P., Katz, A.I. Lancet (1976) [Pubmed]
WikiGenes - Universities