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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Isobrassinin and its analogues: Novel types of antiproliferative agents.

Isobrassinin (2-(S-methyldithiocarbamoylaminomethyl)indole (7a), a regioisomer of the cruciferous phytoalexin brassinin (1), exerted marked antiproliferative effects on the HeLa, A431 and MCF7 cell lines (>78.6% inhibition at 30muM). For structure-activity relationships, further analogues were synthesized. The highest cytotoxic effect was displayed by 2-phenylimino-1,3-thiazino[5,6-b]indole (10) (10muM, 76.8%-HeLa and 46.3%-MCF7). The effect of the natural phytoalexin brassinin was also determined.[1]

References

  1. Isobrassinin and its analogues: Novel types of antiproliferative agents. Csom??s, P., Zupk??, I., R??thy, B., Fodor, L., Falkay, G., Bern??th, G. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
 
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