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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Efficacy of ambruticin analogs in a murine model of coccidioidomycosis.

Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two analogs of this compound with greater in vitro potency were tested against lethal murine Coccidioides infection. Both improved the survival of mice over that of controls; one resulted in near-sterilization of infection.[1]


  1. Efficacy of ambruticin analogs in a murine model of coccidioidomycosis. Shubitz, L.F., Galgiani, J.N., Tian, Z.Q., Zhong, Z., Timmermans, P., Katz, L. Antimicrob. Agents Chemother. (2006) [Pubmed]
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