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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Store-operated Ca(2+) entry: a STIMulating stOrai.

Store-operated Ca(2+) entry (SOCE) mediates much of the Ca(2+) entry evoked by receptors that stimulate phospholipase C. However, for 20 years, the plasma membrane Ca(2+) channel and the signal linking its activation to loss of Ca(2+) from the endoplasmic reticulum (ER) have eluded detection. But the search might now be over. Two proteins, STIM1 (the ER Ca(2+) sensor) and Orai1 (the Ca(2+) channel), have recently been identified as the missing links in SOCE.[1]


  1. Store-operated Ca(2+) entry: a STIMulating stOrai. Taylor, C.W. Trends Biochem. Sci. (2006) [Pubmed]
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