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Walker, C. et al.

C. Walker, B. Haylock, D. Husband, K.A. Joyce, D. Fildes, M.D. Jenkinson, T. Smith, J. Broome, K. Kopitzki, D.G. du Plessis, J. Prosser, S. Vinjamuri, P.C. Warnke,

Genetic and metabolic predictors of chemosensitivity in oligodendroglial neoplasms.

The -1p/-19q genotype predicts chemosensitivity in oligodendroglial neoplasms, but some with intact 1p/19q also respond and not all with 1p/19q loss derive durable benefit from chemotherapy. We have evaluated the predictive and prognostic significance of pretherapy (201)Tl and (18)F-FDG SPECT and genotype in 38 primary and 10 recurrent oligodendroglial neoplasms following PCV chemotherapy. 1p/19q loss was seen in 8/15 OII, 6/15 OAII, 7/7 OIII, 3/11 OAIII and was associated with response (Fisher-Exact: P=0.000) and prolonged progression-free (log-rank: P=0.002) and overall survival (OS) (log-rank: P=0.0048). Response was unrelated to metabolism, with tumours with high or low metabolism showing response. Increased (18)F-FDG or (201)Tl uptake predicted shorter progression-free survival (PFS) in the series (log-rank: (201)Tl P=0.0097, (18)F-FDG P=0.0170) and in cases with or without the -1p/-19q genotype. Elevated metabolism was associated with shorter OS in cases with intact 1p/19q (log-rank: (18)F-FDG P=0.0077; (201)Tl P=0.0004) and shorter PFS in responders (log-rank: (18)F-FDG P=0.005; (201)Tl P=0.0132). (201)Tl uptake and 1p/19q loss were independent predictors of survival in multivariate analysis. In this initial study, (201)Tl and (18)F-FDG uptake did not predict response to PCV, but may be associated with poor survival following therapy irrespective of genotype. This may be clinically useful warranting further study.[1]

References

Genetic and metabolic predictors of chemosensitivity in oligodendroglial neoplasms. Walker, C., Haylock, B., Husband, D., Joyce, K.A., Fildes, D., Jenkinson, M.D., Smith, T., Broome, J., Kopitzki, K., du Plessis, D.G., Prosser, J., Vinjamuri, S., Warnke, P.C. Br. J. Cancer (2006) [Pubmed]

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