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Benavente, F. et al.

Benavente, Gim??nez, Olivieri, Barbosa, Sanz-Nebot,

Estimation of the composition of recombinant human erythropoietin mixtures using capillary electrophoresis and multivariate calibration methods.

A multivariate calibration method using partial least-squares (PLS) is proposed in order to characterize binary mixtures of two types of recombinant human erythropoietin (epoetin alpha and beta), based on the analysis of the highly overlapped UV-electrophoretic profiles obtained with the CE methodology recommended by the European Pharmacopoeia (EurPh). A two-factor PLS-1 model was developed and validated using mixtures of alpha and beta epoetins. Glycoforms were identified according to their effective electrophoretic mobility values and the normalized area values of each glycoform peak were used as multivariate data. Calibration and validation results were satisfactory. The PLS-1 model was successfully used for determination of epoetin alpha and beta contents in the rHuEPO provided by the EurPh as a biological reference product.[1]

References

Estimation of the composition of recombinant human erythropoietin mixtures using capillary electrophoresis and multivariate calibration methods. Benavente, F., Gim??nez, E., Olivieri, A.C., Barbosa, J., Sanz-Nebot, V. Electrophoresis (2006) [Pubmed]

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