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Gene Review

PLS1  -  plastin 1

Homo sapiens

Synonyms: I-plastin, Intestine-specific plastin, Plastin-1
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Disease relevance of PLS1


High impact information on PLS1


Biological context of PLS1

  • Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells [7].
  • We found that both plastin isoforms contain a potential calcium binding site near the N terminus [6].
  • Depletion of intracellular calcium did not affect FcgammaRII-activated L-plastin phosphorylation, demonstrating that any potential regulation of plastin function by calcium did not affect its phosphorylation [8].
  • In this report, we describe the genetic linkage mapping of six of these polymorphic proteins (PNIA1-PNIA6), the identification by genetic linkage of a seventh (glyoxalase 1 on 6p21), and support for the mapping of an eighth (plastin or LCP1) to near the ESD locus on Chr 13 [9].
  • Three multivariate calibration methods, partial least squares (PLS-1 and PLS-2) and principal component regression (PCR), were applied to the simultaneous determination of three flavour enhancers (inosine 5'-monophosphate, guanosine 5'-monophosphate and monosodium glutamate), in mixtures by ultraviolet/visible absorption spectrophotometry [10].

Anatomical context of PLS1


Associations of PLS1 with chemical compounds

  • An array of six potentiometric sensors, constituted by two creatinine biosensors and four ion selective electrodes for potassium, sodium, ammonium and calcium was calibrated and a multivariate model based on PLS1 for the response to creatinine was obtained and validated [12].
  • Furthermore, a calibration model using a PLS1 was proposed for the quantification of mannose in the samples obtained by precipitation with 60% ethanol aqueous solutions [13].
  • Selected wavelengths in the region 800-2,000 nm were used to make a PLS1 -regression with propionate [14].
  • Quantification using a PLS1 regression algorithm showed good correlation with DON reference data, but a rather high standard error of prediction (SEP) with 600 microg/kg (DR) and 490 microg/kg (ATR), respectively, for ergosterol [15].
  • Regulation of synthesis of the transformation-induced protein, leukocyte plastin, by ovarian steroid hormones [16].

Regulatory relationships of PLS1


Other interactions of PLS1

  • Classification models were developed to discriminate between the presence and absence of animal-origin meals in compound feeds using two forms of discriminant partial least squares (PLS) regression: the algorithms PLS1 and PLS2 [17].
  • Actin interaction with L-plastin, a plastin/fimbrins isoform of the alpha-actinin family of molecules, is poorly characterized, from the biochemical point of view [18].
  • The PLS-1 model was successfully used for determination of epoetin alpha and beta contents in the rHuEPO provided by the EurPh as a biological reference product [19].
  • Northern blot analysis revealed that two known sequences, fibrinogen gamma chain and plastin mRNAs were down regulated by TCDD in a time-dependent manner, whereas two unknown mRNAs were induced by TCDD treatment [20].

Analytical, diagnostic and therapeutic context of PLS1


  1. Cytoskeletal rearrangements and the functional role of T-plastin during entry of Shigella flexneri into HeLa cells. Adam, T., Arpin, M., Prévost, M.C., Gounon, P., Sansonetti, P.J. J. Cell Biol. (1995) [Pubmed]
  2. An invasion-associated Salmonella protein modulates the actin-bundling activity of plastin. Zhou, D., Mooseker, M.S., Galán, J.E. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. Abundant synthesis of the transformation-induced protein of neoplastic human fibroblasts, plastin, in normal lymphocytes. Goldstein, D., Djeu, J., Latter, G., Burbeck, S., Leavitt, J. Cancer Res. (1985) [Pubmed]
  4. Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization. Grimbert, P., Valanciute, A., Audard, V., Pawlak, A., Le gouvelo, S., Lang, P., Niaudet, P., Bensman, A., Guellaën, G., Sahali, D. J. Exp. Med. (2003) [Pubmed]
  5. Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney. Lin, C.S., Shen, W., Chen, Z.P., Tu, Y.H., Matsudaira, P. Mol. Cell. Biol. (1994) [Pubmed]
  6. Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain. Lin, C.S., Aebersold, R.H., Leavitt, J. Mol. Cell. Biol. (1990) [Pubmed]
  7. Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells. Lin, C.S., Park, T., Chen, Z.P., Leavitt, J. J. Biol. Chem. (1993) [Pubmed]
  8. FcgammaRII-mediated adhesion and phagocytosis induce L-plastin phosphorylation in human neutrophils. Jones, S.L., Brown, E.J. J. Biol. Chem. (1996) [Pubmed]
  9. Linkage mapping of human polymorphic proteins identified by two-dimensional electrophoresis. Goldman, D., O'Brien, S.J., Lucas-Derse, S., Dean, M. Genomics (1991) [Pubmed]
  10. Multicomponent determination of flavour enhancers in food preparations by partial least squares and principal component regression modelling of spectrophotometric data. Durán-Merás, I., Muńoz de la Peña, A., Espinosa-Mansilla, A., Salinas, F. The Analyst. (1993) [Pubmed]
  11. Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts. Lin, C.S., Aebersold, R.H., Kent, S.B., Varma, M., Leavitt, J. Mol. Cell. Biol. (1988) [Pubmed]
  12. Array of potentiometric sensors for the analysis of creatinine in urine samples. Magalhães, J.M., Machado, A.A. The Analyst. (2002) [Pubmed]
  13. Fourier transform infrared spectroscopy and chemometric analysis of white wine polysaccharide extracts. Coimbra, M.A., Gonçalves, F., Barros, A.S., Delgadillo, I. J. Agric. Food Chem. (2002) [Pubmed]
  14. Early warning of disturbances in a laboratory-scale MSW biogas process. Hansson, M., Nordberg, A., Sundh, I., Mathisen, B. Water Sci. Technol. (2002) [Pubmed]
  15. A comparative study of mid-infrared diffuse reflection (DR) and attenuated total reflection (ATR) spectroscopy for the detection of fungal infection on RWA2-corn. Kos, G., Krska, R., Lohninger, H., Griffiths, P.R. Analytical and bioanalytical chemistry. (2004) [Pubmed]
  16. Regulation of synthesis of the transformation-induced protein, leukocyte plastin, by ovarian steroid hormones. Leavitt, J., Chen, Z.P., Lockwood, C.J., Schatz, F. Cancer Res. (1994) [Pubmed]
  17. Optimization of discriminant partial least squares regression models for the detection of animal by-product meals in compound feedingstuffs by near-infrared spectroscopy. P??rez-Mar??n, D.C., Garrido-Varo, A., Guerrero, J.E. Applied spectroscopy (2006) [Pubmed]
  18. Biochemical characterization of the L-plastin-actin interaction shows a resemblance with that of alpha-actinin and allows a distinction to be made between the two actin-binding domains of the molecule. Lebart, M.C., Hubert, F., Boiteau, C., Ventéo, S., Roustan, C., Benyamin, Y. Biochemistry (2004) [Pubmed]
  19. Estimation of the composition of recombinant human erythropoietin mixtures using capillary electrophoresis and multivariate calibration methods. Benavente, F., Gim??nez, E., Olivieri, A.C., Barbosa, J., Sanz-Nebot, V. Electrophoresis (2006) [Pubmed]
  20. Identification of dioxin-responsive genes in Hep G2 cells using differential mRNA display RT-PCR. Wang, X., Harris, P.K., Ulrich, R.G., Voorman, R.L. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  21. Effect of refining on pulp surface charge accessible to polydadmac and FTIR characteristic bands of high yield kraft fibres. Bhardwaj, N.K., Hoang, V., Nguyen, K.L. Bioresour. Technol. (2007) [Pubmed]
  22. Evaluation of multiwavelength chromatograms for the quantification of mixtures of pesticides by high-performance liquid chromatography-diode array detection with multivariate calibration. Martínez Galera, M., Martínez Vidal, J.L., Garrido Frenich, A., Gil García, M.D. Journal of chromatography. A. (1997) [Pubmed]
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