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Kim, W.Y. et al.

The Regulation of INK4/ ARF in Cancer and Aging.

Loss of the INK4a/ ARF/INK4b locus on chromosome 9p21 is among the most frequent cytogenetic events in human cancer. The products of the locus-p15(INK4b), p16(INK4a), and ARF-play widespread and independent roles in tumor suppression. Recent data also suggest that expression of p16(INK4a) induces an age-dependent decrease in the proliferative capacity of certain tissue-specific stem cells and unipotent progenitors. Here, we discuss the regulation and role of p16(INK4a), ARF, and p15(INK4b) in cancer and aging.[1]

References

The Regulation of INK4/ARF in Cancer and Aging. Kim, W.Y., Sharpless, N.E. Cell (2006) [Pubmed]

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