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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Aquaporin-4 deficiency down-regulates glutamate uptake and GLT-1 expression in astrocytes.

The role of aquaporin-4 in water transport has been extensively investigated, while little information exists regarding its contribution to astrocytic functions such as the action to glutamatergic transmission. Since aquaporin-4 has been detected widely co-localized with glutamate transporter 1 ( GLT-1) and glutamate transporters also present water transport properties, we investigated the regulative role of aquporin-4 on glutamate transporter using primary cultured astrocytes from aquaporin-4 knockout (AQP4(-/-)) mice. It was demonstrated that lack of aquaporin-4 down-regulated astrocytic expression of GLT-1 but not of glutamate/aspartate transporter ( GLAST). The result from [(3)H]d,l-glutamate uptake analysis showed a lower uptake capability in AQP4(-/-) astrocytes. Furthermore, MTT and LDH assays indicated less cellular toxicity induced by excessive glutamate in AQP4(-/-) genotype. These findings provide direct evidences for the first time that aquaporin-4 plays an important role in the function of glutamate transporters. And the present study will improve our understanding of aquaporin-4-glutamanergic biology.[1]


  1. Aquaporin-4 deficiency down-regulates glutamate uptake and GLT-1 expression in astrocytes. Zeng, X.N., Sun, X.L., Gao, L., Fan, Y., Ding, J.H., Hu, G. Mol. Cell. Neurosci. (2007) [Pubmed]
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