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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Arc/Arg3.1: linking gene expression to synaptic plasticity and memory.

Arc/Arg3.1 is an effector immediate-early gene implicated in the consolidation of memories. Although cloned a decade ago, the physiological role of Arc/Arg3.1 in the brain has remained elusive. Four papers in this issue of Neuron address this function. These studies show that Arc/Arg3.1 regulates endophilin 3 and dynamin 2, two components of the endocytosis machinery. Genetic ablation of Arc/Arg3.1 in mice or overexpression in culture suggest that Arc/Arg3.1 regulates AMPA receptor trafficking and synaptic plasticity. Finally, Arc/Arg3.1 knockout mice show memory retention deficits. These recent developments provide new insights into the function of this popular activity-dependent neuronal marker.[1]


  1. Arc/Arg3.1: linking gene expression to synaptic plasticity and memory. Tzingounis, A.V., Nicoll, R.A. Neuron (2006) [Pubmed]
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