Thymic output: influence factors and molecular mechanism.
Thymus is a primary lymphoid organ, able to generate mature T cells that eventually colonize secondary lymphoid organs, and is therefore essential for peripheral T cell renewal. Recent data showed that normal thymocyte export can be altered by several influence factors including several chemokines, sphingosine1-phosphate ( S1P), transcription factors such as Foxj1, Kruppel-like transcription factor 2 (KLF2) and antigen stimulation, etc. In this review, we summarized the recent reports about study strategies, influence factors and possible molecular mechanisms in thymic output.[1]References
- Thymic output: influence factors and molecular mechanism. Jin, R., Zhang, J., Chen, W.F. Cell. Mol. Immunol. (2006) [Pubmed]
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